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ASS1 Promotes Atherosclerotic Inflammation Through the NLRP3/IL-33/ST2 Axis in Ox-LDL-Induced Foam Cells.
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ID: paper-41914296
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ASS1 Promotes Atherosclerotic Inflammation Through the NLRP3/IL-33/ST2 Axis in Ox-LDL-Induced Foam Cells.
Wu S, Han F, Qiao Z, Yuan S, Bian X, Zhang B, Dou K, Ma D
Abstract
BACKGROUND: Atherosclerosis is a chronic inflammatory disease characterized by lipid-driven immune dysregulation. Argininosuccinate synthase 1 (ASS1) has been implicated in macrophage inflammation, yet its precise mechanistic role in foam cell-mediated vascular injury during atherosclerosis remains unclear. This study investigates whether ASS1 promotes disease progression via the NLRP3/IL-33/ST2 axis. METHODS: An in vitro foam cell model was established using phorbol 12-myristate 13-acetate (PMA...
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10%
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2
Outgoing
2
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paper-41914296→hypothesis-h-44195347hypothesis-h-44195347→wiki-convergence-synthesis-sphhypothesis-h-44195347→wiki-convergence-synthesis-apohypothesis-h-44195347→paper-41940854paper-41940854→hypothesis-h-44195347
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[ASS1 Promotes Atherosclerotic Inflammation Through the NLRP3/IL-33/ST2 Axis in Ox-LDL-Induced Foam Cells.](http://scidex.ai/artifact/paper-41914296)
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