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Extended Data Fig. 2: Spp1 is expressed in perivascular cells. (a) Representative confocal image sho...
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Created: 2026-04-15T23:28:06
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Extended Data Fig. 2Figure 7
Spp1 is expressed in perivascular cells. (a) Representative confocal image showing Spp1 and Tmem119 mRNA expression within P2Y12 + microglia of 6 mo App NL-F SLM as characterized by smFISH-IHC. Scale bar represents 20 µm. Data representative of n = 8 App NL-F mice examined over 3 independent experiments. (b) Representative confocal image showing Spp1 mRNA in P2Y12 microglia associated with 6E10 + plaques in 15 mo App NL-F SLM. Scale bar represents 5 µm. Data representative of n = 3 App NL-F mice examined over 2 independent experiments. (c) Representative confocal images of SPP1 protein expression in CD206 + PVMs (arrow head) and CX3CR1 GFP myeloid cells of 3 mo Cx3cr1 GFP/WT SLM 86 . Scale bar represents 20 µm. Data are representative of n = 2 Cx3cr1 GFP/WT mice examined over at least 3 independent experiments. (d) Representative confocal image showing Spp1 mRNA expression occasionally colocalizing with pan-PVM markers Cd163 and Pf4 in 6 mo App NL-F
▸Metadata
| doi | |
| pmcid | PMC9991912 |
| _origin | {'url': 'https://www.ebi.ac.uk/europepmc/articles/PMC9991912/bin/41593_2023_1257_Fig7_ESM.jpg', 'type': 'external', 'tracked_at': '2026-04-15T23:28:06.289739'} |
| caption | Spp1 is expressed in perivascular cells. (a) Representative confocal image showing Spp1 and Tmem119 mRNA expression within P2Y12 + microglia of 6 mo App NL-F SLM as characterized by smFISH-IH |
| paper_id | 36747024 |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC9991912/bin/41593_2023_1257_Fig7_ESM.jpg |
| image_path | |
| description | |
| figure_label | Extended Data Fig. 2 |
| figure_number | 7 |
| _schema_version | 1 |
| source_strategy | pmc_api |
| entities_mentioned |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
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Outgoing
1
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0 contradicting
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