Gramd1B Gene Gram Domain Containing 1B (Gramd1B) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
[@lerma2010] [@hu2009]
Overview
GRAMD1B (GRAM Domain Containing 1B), also known as GRAMD1B, encodes a protein involved in lipid homeostasis and autophagy regulation. The gene is located on chromosome 11q13.4 and encodes a protein of 762 amino acids. GRAMD1 proteins play emerging roles in cellular stress responses relevant to neurodegeneration. [@vincent2013]
Gramd1B Gene Gram Domain Containing 1B (Gramd1B) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
[@lerma2010] [@hu2009]
Overview
GRAMD1B (GRAM Domain Containing 1B), also known as GRAMD1B, encodes a protein involved in lipid homeostasis and autophagy regulation. The gene is located on chromosome 11q13.4 and encodes a protein of 762 amino acids. GRAMD1 proteins play emerging roles in cellular stress responses relevant to neurodegeneration. [@vincent2013]
Function
GRAMD1B participates in: [@matute2011]
Lipid droplet regulation: Localizes to lipid droplet membranes
[Autophagy](/entities/autophagy) initiation: Interacts with autophagy machinery
ER stress response: Modulates [unfolded protein response](/entities/unfolded-protein-response)
Cholesterol trafficking: Affects cellular cholesterol distribution
The protein contributes to:
Cellular lipid homeostasis
Membrane remodeling processes
Protein aggregate clearance
Neuronal survival under stress
Disease Associations
Alzheimer's Disease (AD)
GRAMD1B expression altered in AD brain
Affects lipid metabolism in [neurons](/entities/neurons)
May influence [amyloid precursor protein](/entities/app-protein) processing
The study of Gramd1B Gene Gram Domain Containing 1B (Gramd1B) has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.