Sphingomyelin Synthase Activators for Raft Remodeling

Sphingomyelin synthase (SMS) activation for membrane raft remodeling targets the pathological lipid imbalance at synaptic membranes — specifically the shift from sphingomyelin to ceramide — that disrupts synaptic signaling, promotes amyloidogenic processing, and drives neuronal apoptosis in neurodegenerative diseases. **Sphingomyelin-Ceramide Balance at Synapses** Synaptic membranes are organized into specialized lipid raft microdomains enriched in sphingomyelin, cholesterol, and specific gang...