LAPTM4B Gene

LAPTM4B Gene

Introduction

Laptm4B Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

--- [@lysosomal2021]
title: LAPTM4B [@autophagy2022]
--- [@laptmb2019]

<div class="infobox infobox-gene"> [@lysosomal2023]
<table> [@mtor2020]
<tr><th colspan="2" style="background:#f8f9fa; text-align:center;">LAPTM4B - Lysosomal Associated Transmembrane Protein 4 Beta</th></tr> [@parkinsons2021]
<tr><td><b>Gene Symbol</b></td><td>LAPTM4B</td></tr> [@targeting2022]
<tr><td><b>Full Name</b></td><td>Lysosomal Associated Transmembrane Protein 4 Beta</td></tr>
<tr><td><b>Chromosomal Location</b></td><td>2q21.1</td></tr>
<tr><td><b>NCBI Gene ID</b></td><td>[55355](https://www.ncbi.nlm.nih.gov/gene/55355)</td></tr>
<tr><td><b>Ensembl ID</b></td><td>[ENSG00000167996](https://ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000167996)</td></tr>
<tr><td><b>UniProt ID</b></td><td>[Q9Y5G5](https://www.uniprot.org/uniprot/Q9Y5G5)</td></tr>
<tr><td><b>Associated Diseases</b></td><td>[Alzheimer's Disease](/diseases/alzheimers-disease), [Parkinson's Disease](/diseases/parkinsons-disease), Cancer (Breast, Ovarian, Liver)</td></tr>
<tr><td><b>Protein</b></td><td>[LAPTM4B Protein](/proteins/laptm4b-protein)</td></tr>
</table>
</div>

Overview

LAPTM4B Gene

Introduction

Laptm4B Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

--- [@lysosomal2021]
title: LAPTM4B [@autophagy2022]
--- [@laptmb2019]

<div class="infobox infobox-gene"> [@lysosomal2023]
<table> [@mtor2020]
<tr><th colspan="2" style="background:#f8f9fa; text-align:center;">LAPTM4B - Lysosomal Associated Transmembrane Protein 4 Beta</th></tr> [@parkinsons2021]
<tr><td><b>Gene Symbol</b></td><td>LAPTM4B</td></tr> [@targeting2022]
<tr><td><b>Full Name</b></td><td>Lysosomal Associated Transmembrane Protein 4 Beta</td></tr>
<tr><td><b>Chromosomal Location</b></td><td>2q21.1</td></tr>
<tr><td><b>NCBI Gene ID</b></td><td>[55355](https://www.ncbi.nlm.nih.gov/gene/55355)</td></tr>
<tr><td><b>Ensembl ID</b></td><td>[ENSG00000167996](https://ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000167996)</td></tr>
<tr><td><b>UniProt ID</b></td><td>[Q9Y5G5](https://www.uniprot.org/uniprot/Q9Y5G5)</td></tr>
<tr><td><b>Associated Diseases</b></td><td>[Alzheimer's Disease](/diseases/alzheimers-disease), [Parkinson's Disease](/diseases/parkinsons-disease), Cancer (Breast, Ovarian, Liver)</td></tr>
<tr><td><b>Protein</b></td><td>[LAPTM4B Protein](/proteins/laptm4b-protein)</td></tr>
</table>
</div>

Overview

LAPTM4B (Lysosomal Associated Transmembrane Protein 4 Beta) is a member of the LAPTM family with important roles in lysosomal function, [autophagy](/entities/autophagy), and cell proliferation. Unlike its alpha counterpart, LAPTM4B is frequently overexpressed in cancers and has been studied extensively as a cancer biomarker. In the brain, it plays roles in neuronal survival and is implicated in neurodegenerative diseases.

Gene Structure

The LAPTM4B gene is located on chromosome 2q21.1 and encodes a protein of approximately 347 amino acids. The gene contains multiple exons and is subject to alternative splicing.

Normal Function

Lysosomal Function

LAPTM4B is a lysosomal membrane protein:

• Membrane integration: Multiple transmembrane domains anchor it in lysosomal membranes
• Lysosomal trafficking: Participates in vesicular transport to and from lysosomes
• Autophagy support: Contributes to autophagosome-lysosome fusion events

Cell Proliferation

LAPTM4B has growth-promoting functions:

• Cell cycle regulation: Modulates cell cycle progression
• Growth factor signaling: Affects EGFR and other receptor trafficking
• Anti-apoptotic effects: Inhibits [apoptosis](/entities/apoptosis) through multiple pathways

Autophagy Regulation

The protein modulates autophagy:

• [mTOR](/mechanisms/mtor-signaling-pathway) signaling: May affect mTORC1 activity
• Autophagosome formation: Modulates initiation of autophagy
• Lysosomal function: Supports lysosomal degradation capacity

Expression Pattern

LAPTM4B shows distinct expression patterns:

• Normal tissue: Low expression in most adult tissues
• High expression: Embryonic tissues, regenerating cells
• Cancer: Frequently amplified and overexpressed in breast, ovarian, liver, and other cancers
• Brain: Expressed in [neurons](/entities/neurons) and glia

Role in Neurodegeneration

Alzheimer's Disease

LAPTM4B contributes to AD pathogenesis:

Parkinson's Disease

In Parkinson's disease, LAPTM4B has complex roles:

Cancer Biology

LAPTM4B is an important oncogene:

• Amplification: Frequently amplified in multiple cancer types
• Prognostic marker: High expression correlates with poor prognosis
• Therapeutic target: Potential target for anticancer therapy

See Also

• [LAPTM4B Protein](/proteins/laptm4b-protein)
• [Lysosomal Degradation](/mechanisms/lysosomal-degradation)
• [Autophagy Pathway](/mechanisms/autophagy)
• [Alzheimer's Disease](/diseases/alzheimers-disease)
• [Parkinson's Disease](/diseases/parkinsons-disease)

Background

The study of Laptm4B Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.

Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.

External Links

• [PubMed](https://pubmed.ncbi.nlm.nih.gov/) - Biomedical literature
• [Alzheimer's Disease Neuroimaging Initiative](https://adni.loni.usc.edu/) - Research data
• [Allen Brain Atlas](https://brain-map.org/) - Brain gene expression data

References

Pathway Diagram

The following diagram shows the key molecular relationships involving LAPTM4B Gene discovered through SciDEX knowledge graph analysis: