LRP5 — Low Density Lipoprotein Receptor-Related Protein 5

LRP5 Gene — Low-Density Lipoprotein Receptor-Related Protein 5

Introduction

Lrp5 — Low Density Lipoprotein Receptor Related Protein 5 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

<div class="infobox infobox-gene">
<table>
<tr><th colspan="2" style="background:#6a1b9a; color:white; text-align:center; font-size:1.1em;">LRP5 Gene</th></tr>
<tr><td><strong>Gene Symbol</strong></td><td>LRP5</td></tr>
<tr><td><strong>Full Name</strong></td><td>Low-Density Lipoprotein Receptor-Related Protein 5</td></tr>
<tr><td><strong>Chromosomal Location</strong></td><td>11q13.2</td></tr>
<tr><td><strong>NCBI Gene ID</strong></td><td>[4041](https://www.ncbi.nlm.nih.gov/gene/4041)</td></tr>
<tr><td><strong>OMIM ID</strong></td><td>603506</td></tr>
<tr><td><strong>Ensembl ID</strong></td><td>[ENSG00000162337](https://www.ensembl.org/Homo_sapiens/ENSG00000162337)</td></tr>
<tr><td><strong>UniProt ID</strong></td><td>[O75173](https://www.uniprot.org/uniprot/O75173)</td></tr>
<tr><td><strong>Protein Name</strong></td><td>Low-density lipoprotein receptor-related protein 5</td></tr>
<tr><td><strong>Aliases</strong></td><td>LRP-5, LRP7</td></tr>
<tr><td><strong>Associated Diseases</strong></td><td>Alzheimer's Disease, Osteoporosis-Pseudoglioma Syndrome, Familial Exudative Vitreoretinopathy</td></tr>
</table>
</div>

Overview

LRP5 Gene — Low-Density Lipoprotein Receptor-Related Protein 5

Introduction

Lrp5 — Low Density Lipoprotein Receptor Related Protein 5 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

<div class="infobox infobox-gene">
<table>
<tr><th colspan="2" style="background:#6a1b9a; color:white; text-align:center; font-size:1.1em;">LRP5 Gene</th></tr>
<tr><td><strong>Gene Symbol</strong></td><td>LRP5</td></tr>
<tr><td><strong>Full Name</strong></td><td>Low-Density Lipoprotein Receptor-Related Protein 5</td></tr>
<tr><td><strong>Chromosomal Location</strong></td><td>11q13.2</td></tr>
<tr><td><strong>NCBI Gene ID</strong></td><td>[4041](https://www.ncbi.nlm.nih.gov/gene/4041)</td></tr>
<tr><td><strong>OMIM ID</strong></td><td>603506</td></tr>
<tr><td><strong>Ensembl ID</strong></td><td>[ENSG00000162337](https://www.ensembl.org/Homo_sapiens/ENSG00000162337)</td></tr>
<tr><td><strong>UniProt ID</strong></td><td>[O75173](https://www.uniprot.org/uniprot/O75173)</td></tr>
<tr><td><strong>Protein Name</strong></td><td>Low-density lipoprotein receptor-related protein 5</td></tr>
<tr><td><strong>Aliases</strong></td><td>LRP-5, LRP7</td></tr>
<tr><td><strong>Associated Diseases</strong></td><td>Alzheimer's Disease, Osteoporosis-Pseudoglioma Syndrome, Familial Exudative Vitreoretinopathy</td></tr>
</table>
</div>

Overview

LRP5 (Low-Density Lipoprotein Receptor-Related Protein 5) is a transmembrane receptor that plays critical roles in bone mass regulation, Wnt/beta-catenin signaling, and cholesterol metabolism["@he2004"][@gong2001]. It is a member of the low-density lipoprotein receptor family and functions as a co-receptor for Wnt ligands. LRP5 is widely expressed in bone, retina, and brain, with emerging roles in neurodegenerative diseases.

Normal Function

Wnt Co-Receptor Activity

LRP5 serves as a primary co-receptor in the canonical Wnt/β-catenin signaling pathway:

Bone Metabolism

LRP5 is essential for bone homeostasis:

• Osteoblast Function: Promotes osteoblast differentiation and activity
• Bone Mass: Gain-of-function mutations cause high bone mass
• Calcium Homeostasis: Regulates intestinal calcium absorption
• Fracture Risk: LRP5 variants influence osteoporosis risk

CNS Expression

In the central nervous system:

• Neuronal Development: Regulates neural progenitor cell proliferation
• Synaptic Plasticity: Involved in hippocampal learning and memory
• Myelination: Affects oligodendrocyte function
• [Blood-Brain Barrier](/entities/blood-brain-barrier): Regulates BBB integrity

Role in Neurodegenerative Diseases

Alzheimer's Disease

LRP5 connections to AD include[@de2007][@tan2015]:

• APP Processing: LRP5 modulates [amyloid precursor protein](/entities/app-protein) processing
• [Aβ](/proteins/amyloid-beta) Clearance: Influences Aβ transport across the BBB
• Wnt Signaling: Loss of Wnt signaling in AD brain
• Synaptic Dysfunction: LRP5 deficiency impairs synaptic plasticity
• [Tau](/proteins/tau) Pathology: Cross-talk between Wnt and tau pathogenesis

Parkinson's Disease

In PD:

• Dopaminergic [Neurons](/entities/neurons): LRP5 affects survival of dopaminergic neurons
• Neuroinflammation: Wnt pathway regulates microglial activation
• Mitochondrial Function: Wnt signaling and mitochondrial health intersect

Other Disorders

• Amyotrophic Lateral Sclerosis: LRP5 in motor neuron disease
• Multiple Sclerosis: Demyelination and LRP5 signaling
• Stroke: LRP5 in ischemic injury response

Therapeutic Implications

Target Rationale

LRP5 is a promising therapeutic target:

Drug Development Status

• No LRP5-targeted drugs in clinical trials for neurodegeneration
• Wnt pathway modulators in development for other indications
• Gene therapy approaches to enhance LRP5 expression

Genetic Associations

AD Risk

• Several LRP5 SNPs associated with AD risk in genome-wide studies
• LRP5 variants may modify age of onset
• Interaction with [APOE](/proteins/apoe) status

Bone-LRP5-Brain Axis

Emerging evidence links bone and brain health through LRP5:

• Osteoporosis associated with increased dementia risk
• Shared signaling pathways
• Potential for dual-targeting therapeutics

See Also

• [Wnt Signaling in Neurodegeneration](/mechanisms/wnt-signaling-pathway-neurodegeneration)
• [Alzheimer's Disease](/diseases/alzheimers-disease)
• [Parkinson's Disease](/diseases/parkinsons-disease)
• [LRP5 Protein](/proteins/lrp5)
• [Beta-Catenin Signaling](/mechanisms/beta-catenin-signaling)

External Links

• [NCBI Gene: LRP5](https://www.ncbi.nlm.nih.gov/gene/4041)
• [UniProt: O75173](https://www.uniprot.org/uniprot/O75173)
• [Ensembl: ENSG00000162337](https://www.ensembl.org/Homo_sapiens/ENSG00000162337)
• [OMIM: 604271](https://www.omim.org/entry/604271)

Background

The study of Lrp5 — Low Density Lipoprotein Receptor Related Protein 5 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.

Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.

References

Pathway Diagram

The following diagram shows the key molecular relationships involving LRP5 — Low Density Lipoprotein Receptor-Related Protein 5 discovered through SciDEX knowledge graph analysis: