Pericyte Contractility Reset via Selective PDGFR-β Agonism

## **Molecular Mechanism and Rationale** Pericytes are contractile cells that wrap around capillaries and play a crucial role in maintaining blood-brain barrier (BBB) integrity, regulating cerebral blood flow, and facilitating interstitial fluid drainage through the glymphatic system. In neurodegenerative diseases, pericyte dysfunction manifests as loss of contractile tone, altered perivascular space dimensions, and compromised vascular integrity. The platelet-derived growth factor receptor-β (...