Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about LRP5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | LRP5 |
| Full Name | Low Density Lipoprotein Receptor-Related Protein 5 |
| Aliases | Page for LRP5 Protein |
| Protein Type | Receptor |
| Function | Wnt Binding: LRP5 binds Wnt ligands (Wnt1, Wnt3, Wnt3a) in conjunction with Frizzled receptors |
| Primary Expression | the central nervous system where it plays important roles in neuronal development, synaptic plasticity, and cognitive function[@gong2001] |
| Molecular Weight | 179 kDa |
| Amino Acids | 1615 aa |
| Pathways | Wnt, Wnt signaling, Wnt Signaling |
| UniProt ID | [O75177](https://www.uniprot.org/uniprot/O75177) |
| Ensembl ID | ENSG00000162337 |
| GeneCards | LRP5 |
| Human Protein Atlas | LRP5 |
| Osteoblast Function | Promotes osteoblast differentiation and activity |
| Bone Mass | Gain-of-function mutations cause high bone mass |
| Associated Diseases | ALS, Aging, Atherosclerosis, Autosomal Dominant Polycystic Kidney Diseases, Autosomal Dominant Polycystic Liver Diseases |
| Interactions | Gpr124, APOE, APOE4, LRP6, WNT, CANCER |
| KG Connections | 120 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
LRP5["<b>LRP5</b>"]
Cancer{"Cancer"}
LRP5 -->|"associated with"| Cancer
Neurodegeneration{"Neurodegeneration"}
LRP5 -->|"associated with"| Neurodegeneration
Cardiovascular{"Cardiovascular"}
LRP5 -->|"associated with"| Cardiovascular
Als{"Als"}
LRP5 -->|"associated with"| Als
Aging{"Aging"}
LRP5 -->|"associated with"| Aging
Hypertension{"Hypertension"}
LRP5 -->|"associated with"| Hypertension
Atherosclerosis{"Atherosclerosis"}
LRP5 -->|"associated with"| Atherosclerosis
Stroke{"Stroke"}
LRP5 -->|"associated with"| Stroke
Ms{"Ms"}
LRP5 -->|"associated with"| Ms
Heart_Failure{"Heart Failure"}
LRP5 -->|"associated with"| Heart_Failure
LRP5 -->|"regulates"| Atherosclerosis
LRP5 -->|"regulates"| Cardiovascular
LRP8["LRP8"]
LRP8 -->|"associated with"| LRP5
LRP1B["LRP1B"]
LRP1B -->|"associated with"| LRP5
PAH["PAH"]
PAH -->|"associated with"| LRP5
LRP4["LRP4"]
LRP4 -->|"associated with"| LRP5
LDLR["LDLR"]
LDLR -->|"associated with"| LRP5
LRP6["LRP6"]
LRP6 -->|"associated with"| LRP5
LRP1["LRP1"]
LRP1 -->|"associated with"| LRP5
LRP2["LRP2"]
LRP2 -->|"associated with"| LRP5
LDL["LDL"]
LDL -->|"associated with"| LRP5
STROKE["STROKE"]
STROKE -->|"associated with"| LRP5
NEURODEGENERATION["NEURODEGENERATION"]
NEURODEGENERATION -->|"associated with"| LRP5
CANCER["CANCER"]
CANCER -->|"associated with"| LRP5
style LRP5 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Wnt7 | binds | protein | 0.80 |
| Reck | binds | protein | 0.80 |
| Familial Exudative Vitreoretinopathy | associated_with | disease | 0.80 |
| Gpr124 | interacts_with | protein | 0.70 |
| Autosomal Dominant Polycystic Kidney Diseases | associated_with | disease | 0.70 |
| Autosomal Dominant Polycystic Liver Diseases | associated_with | disease | 0.70 |
| Cancer | associated_with | disease | 0.65 |
| Neurodegeneration | associated_with | disease | 0.65 |
| Cardiovascular | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Aging | associated_with | disease | 0.65 |
| Hypertension | associated_with | disease | 0.65 |
| Atherosclerosis | associated_with | disease | 0.65 |
| Stroke | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Heart Failure | associated_with | disease | 0.65 |
| Atherosclerosis | regulates | disease | 0.65 |
| Cardiovascular | regulates | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Ftd | associated_with | disease | 0.65 |
| ALS | associated_with | disease | 0.65 |
| ALS | regulates | disease | 0.65 |
| Heart Failure | activates | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Cardiovascular | activates | disease | 0.65 |
| Hypertension | activates | disease | 0.65 |
| Atherosclerosis | activates | disease | 0.65 |
| Neurodegeneration | activates | disease | 0.65 |
| LRP1 | associated_with | gene | 0.60 |
| LRP2 | associated_with | gene | 0.60 |
| LRP1B | associated_with | gene | 0.60 |
| LRP4 | associated_with | gene | 0.60 |
| PAH | associated_with | gene | 0.60 |
| LDLR | associated_with | gene | 0.60 |
| LRP6 | associated_with | gene | 0.60 |
| LRP8 | associated_with | gene | 0.60 |
| REELIN | associated_with | gene | 0.60 |
| APOE | activates | gene | 0.60 |
| SEMA3F | associated_with | gene | 0.60 |
| APOE4 | activates | gene | 0.60 |
| LRP1 | expressed_in | gene | 0.60 |
| SMAD6 | regulates | gene | 0.60 |
| TET2 | regulates | gene | 0.60 |
| SMAD6 | associated_with | gene | 0.60 |
| TET2 | associated_with | gene | 0.60 |
| LRP6 | activates | gene | 0.60 |
| LRP6 | interacts_with | gene | 0.60 |
| Lipid Metabolism | associated_with | pathway | 0.60 |
| Wnt | associated_with | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| LRP8 | associated_with | gene | 0.60 |
| LRP1B | associated_with | gene | 0.60 |
| PAH | associated_with | gene | 0.60 |
| LRP4 | associated_with | gene | 0.60 |
| LDLR | associated_with | gene | 0.60 |
| LRP6 | associated_with | gene | 0.60 |
| LRP1 | associated_with | gene | 0.60 |
| LRP2 | associated_with | gene | 0.60 |
| REELIN | associated_with | gene | 0.60 |
| PAH | activates | gene | 0.60 |
| APOE | activates | gene | 0.60 |
| APOE4 | activates | gene | 0.60 |
| APP | activates | gene | 0.60 |
| SEMA3F | associated_with | gene | 0.60 |
| DKK1 | expressed_in | gene | 0.60 |
| LDL | associated_with | gene | 0.60 |
| STROKE | associated_with | gene | 0.60 |
| NEURODEGENERATION | associated_with | gene | 0.60 |
| CANCER | associated_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| AGING | associated_with | gene | 0.60 |
| APOER2 | associated_with | gene | 0.60 |
| WNT | associated_with | gene | 0.60 |
| AMYLOID | activates | gene | 0.60 |
| APOE3 | activates | gene | 0.60 |
| DENDRITE | activates | gene | 0.60 |
| NEURODEGENERATION | activates | gene | 0.60 |
| RNA | associated_with | gene | 0.60 |
| WNT | expressed_in | gene | 0.60 |
| LRP1 | expressed_in | gene | 0.50 |
| SEMA3F | expressed_in | gene | 0.50 |
| LDLR | co_expressed_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||