gene

LRP5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LRP5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

120Connections
0Hypotheses
0Analyses
50Outgoing
32Incoming

Summary

LRP5 gene page for neurodegenerative disease research

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🧬 Gene Info
Gene SymbolLRP5
Full NameLow Density Lipoprotein Receptor-Related Protein 5
AliasesPage for LRP5 Protein
Protein TypeReceptor
FunctionWnt Binding: LRP5 binds Wnt ligands (Wnt1, Wnt3, Wnt3a) in conjunction with Frizzled receptors
Primary Expressionthe central nervous system where it plays important roles in neuronal development, synaptic plasticity, and cognitive function[@gong2001]
Molecular Weight179 kDa
Amino Acids1615 aa
PathwaysWnt, Wnt signaling, Wnt Signaling
UniProt ID[O75177](https://www.uniprot.org/uniprot/O75177)
Ensembl IDENSG00000162337
GeneCardsLRP5
Human Protein AtlasLRP5
Osteoblast FunctionPromotes osteoblast differentiation and activity
Bone MassGain-of-function mutations cause high bone mass
Associated DiseasesALS, Aging, Atherosclerosis, Autosomal Dominant Polycystic Kidney Diseases, Autosomal Dominant Polycystic Liver Diseases
InteractionsGpr124, APOE, APOE4, LRP6, WNT, CANCER
KG Connections120 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

LRP5 — Low Density Lipoprotein Receptor-Related Protein 5

gene · 640 words

GSK-3β in Neurodegeneration

mechanism · 5020 words

WNT4 Gene

gene · 3328 words

WNT7A Gene

gene · 3221 words

VPS35 Retromer Dysfunction Parkinson's Disease Causal Chain

mechanism · 3215 words

Wnt-Beta-Catenin Signaling Dysfunction Hypothesis in Parkinson's Disease

hypothesis · 3146 words

Pathway Diagram

graph TD
    LRP5["<b>LRP5</b>"]
    Cancer{"Cancer"}
    LRP5 -->|"associated with"| Cancer
    Neurodegeneration{"Neurodegeneration"}
    LRP5 -->|"associated with"| Neurodegeneration
    Cardiovascular{"Cardiovascular"}
    LRP5 -->|"associated with"| Cardiovascular
    Als{"Als"}
    LRP5 -->|"associated with"| Als
    Aging{"Aging"}
    LRP5 -->|"associated with"| Aging
    Hypertension{"Hypertension"}
    LRP5 -->|"associated with"| Hypertension
    Atherosclerosis{"Atherosclerosis"}
    LRP5 -->|"associated with"| Atherosclerosis
    Stroke{"Stroke"}
    LRP5 -->|"associated with"| Stroke
    Ms{"Ms"}
    LRP5 -->|"associated with"| Ms
    Heart_Failure{"Heart Failure"}
    LRP5 -->|"associated with"| Heart_Failure
    LRP5 -->|"regulates"| Atherosclerosis
    LRP5 -->|"regulates"| Cardiovascular
    LRP8["LRP8"]
    LRP8 -->|"associated with"| LRP5
    LRP1B["LRP1B"]
    LRP1B -->|"associated with"| LRP5
    PAH["PAH"]
    PAH -->|"associated with"| LRP5
    LRP4["LRP4"]
    LRP4 -->|"associated with"| LRP5
    LDLR["LDLR"]
    LDLR -->|"associated with"| LRP5
    LRP6["LRP6"]
    LRP6 -->|"associated with"| LRP5
    LRP1["LRP1"]
    LRP1 -->|"associated with"| LRP5
    LRP2["LRP2"]
    LRP2 -->|"associated with"| LRP5
    LDL["LDL"]
    LDL -->|"associated with"| LRP5
    STROKE["STROKE"]
    STROKE -->|"associated with"| LRP5
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"associated with"| LRP5
    CANCER["CANCER"]
    CANCER -->|"associated with"| LRP5
    style LRP5 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (88)

TargetRelationTypeStr
Wnt7bindsprotein0.80
Reckbindsprotein0.80
Familial Exudative Vitreoretinopathyassociated_withdisease0.80
Gpr124interacts_withprotein0.70
Autosomal Dominant Polycystic Kidney Diseasesassociated_withdisease0.70

Incoming (32)

SourceRelationTypeStr
LRP8associated_withgene0.60
LRP1Bassociated_withgene0.60
PAHassociated_withgene0.60
LRP4associated_withgene0.60
LDLRassociated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found