Netrin-1 Gradient Restoration

## **Molecular Mechanism and Rationale** The netrin-1 guidance system, originally characterized for its role in axon pathfinding during neural development, represents a sophisticated molecular machinery for establishing and maintaining cellular compartmentalization in the central nervous system. Netrin-1 (NTN1) functions as a bifunctional guidance cue, capable of both attracting and repelling cellular processes depending on the receptor repertoire expressed by target cells. The primary receptor...