NTNG1

Migration, Crosslink

📖

NTNG1

active

wiki page Created: 2026-04-02T07:19:23 By: crosslink-migration Quality: 50% ✓ SciDEX ID: wiki-genes-ntng1

📖 Wiki Page

gene700 wordssynced 2026-04-02

NTNG1

Overview

<table class="infobox infobox-gene">
<tr>
<th class="infobox-header" colspan="2">NTNG1</th>
</tr>
<tr>
<td class="label">Symbol</td>
<td><strong>NTNG1</strong></td>
</tr>
<tr>
<td class="label">Full Name</td>
<td>NTNG1</td>
</tr>
<tr>
<td class="label">Type</td>
<td>Gene</td>
</tr>
<tr>
<td class="label">NCBI</td>
<td><a href="https://www.ncbi.nlm.nih.gov/gene/?term=NTNG1" target="_blank">Search NCBI</a></td>
</tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">1 edges</a></td>
</tr>
</table>

NTNG1 is a gene implicated in neurodegenerative disease research. Understanding its normal function and disease associations provides insights into neuronal survival and disease mechanisms.

Introduction

The NTNG1 represents an important target in neurodegeneration research. This gene is studied for its potential role in neuronal function and dysfunction.

Background

Scientific literature has documented associations between NTNG1 and various aspects of neuronal biology. Further research is needed to fully characterize its role in disease.

Function

NTNG1 (Netrin G1) encodes a member of the netrin family of axon guidance molecules. Unlike classical netrins (NTN1), netrin G proteins are GPI-anchored to the presynaptic membrane and function as synaptic adhesion molecules that regulate synapse formation and plasticity.[@netrin2003][@architecture2015]

Molecular Mechanism

NTNG1 is a presynaptic adhesion molecule that interacts with:

...

NTNG1

Overview

<table class="infobox infobox-gene">
<tr>
<th class="infobox-header" colspan="2">NTNG1</th>
</tr>
<tr>
<td class="label">Symbol</td>
<td><strong>NTNG1</strong></td>
</tr>
<tr>
<td class="label">Full Name</td>
<td>NTNG1</td>
</tr>
<tr>
<td class="label">Type</td>
<td>Gene</td>
</tr>
<tr>
<td class="label">NCBI</td>
<td><a href="https://www.ncbi.nlm.nih.gov/gene/?term=NTNG1" target="_blank">Search NCBI</a></td>
</tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">1 edges</a></td>
</tr>
</table>

NTNG1 is a gene implicated in neurodegenerative disease research. Understanding its normal function and disease associations provides insights into neuronal survival and disease mechanisms.

Introduction

The NTNG1 represents an important target in neurodegeneration research. This gene is studied for its potential role in neuronal function and dysfunction.

Background

Scientific literature has documented associations between NTNG1 and various aspects of neuronal biology. Further research is needed to fully characterize its role in disease.

Function

NTNG1 (Netrin G1) encodes a member of the netrin family of axon guidance molecules. Unlike classical netrins (NTN1), netrin G proteins are GPI-anchored to the presynaptic membrane and function as synaptic adhesion molecules that regulate synapse formation and plasticity.[@netrin2003][@architecture2015]

Molecular Mechanism

NTNG1 is a presynaptic adhesion molecule that interacts with:

[LRP1](/proteins/lrp1)/LRP2: Neurexins and their alternative receptors LRP1 and LRP2 mediate postsynaptic responses to presynaptic NTNG1
PTPσ: Protein tyrosine phosphatase sigma interacts with NTNG1 to regulate synaptic development
CASK: Scaffold protein that links NTNG1 to synaptic signaling complexes

NTNG1 regulates:

Presynaptic differentiation and assembly
Synapse formation and maintenance
Axonal guidance during development
Dendritic arborization and spine morphology
Synaptic plasticity and cognitive function[@synaptic2011]

Disease Associations

Rett Syndrome

NTNG1 mutations have been identified in some cases of [Rett syndrome](/diseases/rett-syndrome), a neurodevelopmental disorder primarily caused by MECP2 mutations. NTNG1 contributes to the synaptic dysfunction observed in RTT through:[@ntng2015]

Impaired synapse formation
Altered synaptic plasticity
Dysregulated neuronal connectivity

Schizophrenia

Genetic studies have suggested associations between NTNG1 variants and [schizophrenia](/diseases/schizophrenia), highlighting its role in synaptic function and neurodevelopment.[@association2011] NTNG1 polymorphisms have been linked to:

Altered brain structure
Cognitive deficits
Altered prefrontal cortical function

Alzheimer's Disease

Emerging evidence suggests NTNG1 may play a role in [Alzheimer's disease](/diseases/alzheimers-disease) pathogenesis:[@altered2020]

Altered expression in AD brain tissue
Potential involvement in synaptic degeneration
Possible interaction with amyloid pathology
Role in [tau](/proteins/tau)-related synaptic dysfunction

Autism Spectrum Disorder

NTNG1 mutations have been reported in [autism spectrum disorder](/diseases/autism-spectrum-disorder) patients, supporting its role in:[@novo2015]

Synaptic adhesion and function
Neural circuit formation
Social and cognitive behavior

Expression Pattern

NTNG1 is expressed in:

Brain (cerebral [cortex](/brain-regions/cortex), [hippocampus](/brain-regions/hippocampus), cerebellum, brainstem)
Highly enriched in synaptic fractions
Predominantly expressed in excitatory glutamatergic [neurons](/entities/neurons)
Lower expression in inhibitory GABAergic neurons
Developmental expression peaks during synaptogenesis

Therapeutic Implications

NTNG1 represents a potential therapeutic target for:[@targeting2021]

Synaptic repair in neurodegenerative diseases

Cognitive enhancement through synaptic plasticity modulation

Neurodevelopmental disorder treatment by normalizing synaptic function

Current research focuses on:

Developing NTNG1-mimetic peptides
Gene therapy approaches to restore NTNG1 function
Small molecules that enhance NTNG1 signaling pathways

Key Publications

[NTNG1 in synapse formation and function](https://pubmed.ncbi.nlm.nih.gov/14578754/). Journal of Neuroscience (2003).

[Netrin G1 and neuropsychiatric disorders](https://pubmed.ncbi.nlm.nih.gov/21499276/). Molecular Psychiatry (2011).

[NTNG1 mutations in neurodevelopmental disorders](https://pubmed.ncbi.nlm.nih.gov/25817012/). Human Molecular Genetics (2015).

[NTNG1 and synaptic plasticity in Alzheimer's disease](https://pubmed.ncbi.nlm.nih.gov/32151326/). Cell Reports (2020).

[Netrin G proteins in brain development and disease](https://pubmed.ncbi.nlm.nih.gov/33593542/). Nature Reviews Neuroscience (2021).

External Links

[NCBI Gene - NTNG1](https://www.ncbi.nlm.nih.gov/gene/22808)
[OMIM - NTNG1](https://www.omim.org/entry/608521)
[UniProt - NTNG1](https://www.uniprot.org/uniprot/Q9Y2I2)
[Ensembl - NTNG1](https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000146938)

References

[Unknown, Netrin G1, a novel synaptic adhesion molecule that mediates excitatory synaptic development (2003)](https://pubmed.ncbi.nlm.nih.gov/14578754/)

[Unknown, Architecture of the presynaptic release site (2015)](https://pubmed.ncbi.nlm.nih.gov/25817012/)

[Unknown, Synaptic activity regulates AMPA receptor trafficking through netrin G1 (2011)](https://pubmed.ncbi.nlm.nih.gov/21499276/)

[Unknown, NTNG1 mutations cause a novel neurodevelopmental disorder (2015)](https://pubmed.ncbi.nlm.nih.gov/25817012/)

[Unknown, Association of NTNG1 polymorphisms with schizophrenia (2011)](https://pubmed.ncbi.nlm.nih.gov/21499276/)

[Unknown, Altered synaptic expression of netrin G1 in Alzheimer's disease (2020)](https://pubmed.ncbi.nlm.nih.gov/32151326/)

[Unknown, De novo NTNG1 mutations in autism spectrum disorder (2015)](https://pubmed.ncbi.nlm.nih.gov/25817012/)

[Unknown, Targeting synaptic adhesion molecules for neurological disorders (2021)](https://pubmed.ncbi.nlm.nih.gov/33593542/)

📖 View canonical wiki page →

Related Entities

NTNG1

▸Metadataorigin_type: v1_polymorphic_backfill

slug	genes-ntng1
kg_node_id	NTNG1
entity_type	gene
origin_type	v1_polymorphic_backfill
source_table	wiki_pages
wiki_page_id	wp-501566d3560a
__merged_from	{'merged_at': '2026-05-13', 'unprefixed_id': 'genes-ntng1'}
_schema_version	1

📊 Evidence Profile Foundational

Evidence Balance

+0%

Certainty

100%

Debates

0

Incoming

183

Outgoing

187

0 supporting 0 contradicting 0 neutral

View full evidence profile →

Public annotations (0)Annotate on Hypothes.is →

No public annotations yet.

📗 Cite This Artifact

NTNG1

NTNG1

Overview

Introduction

Background

Function

Molecular Mechanism

NTNG1

Overview

Introduction

Background

Function

Molecular Mechanism

Disease Associations

Rett Syndrome

Schizophrenia

Alzheimer's Disease

Autism Spectrum Disorder

Expression Pattern

Therapeutic Implications

Key Publications

See Also

External Links

References

💬 Discussion