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PSEN2 — Presenilin 2

wiki page Created: 2026-04-02 13:40:08 By: crosslink-migration Quality: 50% ✓ SciDEX ID: wiki-genes-psen2
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PSEN2
Metadata
sluggenes-psen2
entity_typegene
kg_node_idPSEN2
🌍 Provenance Graph 1 nodes, 0 edges

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Linked Artifacts (75)
mentions🧫Metal Ion Homeostasis Dysregulation in Alzheimer's Dise70%
mentions🧫Neural Stem Cell Therapy for Alzheimer's Disease70%
mentions📓SEA-AD Gene Expression Analysis: Microglia vs Neurons70%
see_also📓SEA-AD Gene Expression Analysis: Microglia vs Neurons70%
related🧫Metal Ion Homeostasis Dysregulation in Alzheimer's Dise63%
related🧫Neural Stem Cell Therapy for Alzheimer's Disease63%
see_also📖AKT1 Gene60%
see_also📖Alzheimer Indonesia60%
see_also📖ABCA7 (Redirect)60%
see_also📖Packard Center for ALS Research60%
see_also📖a2m60%
see_also📖ABCA1 - ATP-Binding Cassette Transporter A160%
see_also📖ABCA2 Gene - ATP Binding Cassette Subfamily A Member 260%
mentions🧪SASP-Mediated Cholinergic Synapse Disruption50%
mentions🧪Palmitoylation-Targeted BACE1 Trafficking Disruptors50%
mentions🧪GAP43-mediated tunneling nanotube stabilization enhances neu50%
mentions🧪Glial Glycocalyx Remodeling Therapy50%
mentions🧫Metal Ion Homeostasis Dysregulation in Alzheimer's Dise50%
mentions🧫Neural Stem Cell Therapy for Alzheimer's Disease50%
mentions🧪SASP-Mediated Cholinergic Synapse Disruption50%
mentions🧪GAP43-mediated tunneling nanotube stabilization enhances neu50%
mentions🧪Multi-Modal CRISPR Platform for Simultaneous Editing and Mon50%
mentions🧪Selective APOE4 Degradation via Proteolysis Targeting Chimer50%
mentions🧪APOE4 Allosteric Rescue via Small Molecule Chaperones50%
mentions🧪Interfacial Lipid Mimetics to Disrupt Domain Interaction50%
mentions🧪Targeted APOE4-to-APOE3 Base Editing Therapy50%
mentions🧪Competitive APOE4 Domain Stabilization Peptides50%
mentions🧪APOE Isoform Expression Across Glial Subtypes50%
mentions🧪Senescent Microglia Resolution via Maresins-Senolytics Combi50%
mentions🧪PARP1 Inhibition Therapy50%
mentions🧪TREM2 Conformational Stabilizers for Synaptic Discrimination50%
mentions🧪TREM2-mediated microglial tau clearance enhancement50%
mentions🧪Cell-Type Specific TREM2 Upregulation in DAM Microglia50%
mentions🧪GFAP-Positive Reactive Astrocyte Subtype Delineation50%
mentions🧪Excitatory Neuron Vulnerability via SLC17A7 Downregulation50%
mentions🧪Multi-Modal CRISPR Platform for Simultaneous Editing and Mon50%
related🔬What are the mechanisms underlying 4r-tau strain-specific sp50%
related🔬What are the mechanisms underlying senolytic therapy for age50%
related🔬Investigate how lipid raft composition (cholesterol metaboli50%
related🔬What are the mechanisms underlying mitochondrial transfer be50%
related🔬What are the mechanisms underlying 4r-tau strain-specific sp50%
related🔬What are the mechanisms underlying senolytic therapy for age50%
related🔬Investigate how lipid raft composition (cholesterol metaboli50%
related🔬What are the mechanisms underlying mitochondrial transfer be50%
related🔬Analyze circuit-level changes in neurodegeneration using All50%
related🔬CRISPR-based therapeutic approaches for neurodegenerative di50%
related🔬What are the mechanisms underlying tdp-43 phase separation t50%
related🔬SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas50%
mentions📖AAN 2026 — Dementia40%
mentions📖Amsterdam UMC (VUmc)40%
mentions📖Erasmus MC40%
mentions📖Fudan University40%
mentions📖Harvard Medical School40%
mentions📖Harvard University40%
mentions📖KU Leuven40%
mentions📖Marc Hutton40%
mentions📖Peking University40%
mentions📖Peter St George-Hyslop40%
mentions📖Regeneron Pharmaceuticals40%
mentions📖Researcher Rankings40%
mentions📖University of California, Irvine (UCI)40%
mentions📖University of Southern California40%
mentions📖Washington University in St. Louis40%
mentions📖Washington University in St. Louis40%
mentions📖Zhejiang University40%
mentions🔬Analyze circuit-level changes in neurodegeneration using All40%
related🧪SASP-Mediated Cholinergic Synapse Disruption40%
related🧪Palmitoylation-Targeted BACE1 Trafficking Disruptors40%
related🧪GAP43-mediated tunneling nanotube stabilization enhances neu40%
related🧪Glial Glycocalyx Remodeling Therapy40%
mentions🔬What are the mechanisms underlying 4r-tau strain-specific sp35%
mentions🔬What are the mechanisms underlying senolytic therapy for age35%
mentions🔬Investigate how lipid raft composition (cholesterol metaboli35%
mentions🔬What are the mechanisms underlying mitochondrial transfer be35%
mentions🔬CRISPR-based therapeutic approaches for neurodegenerative di35%

💬 Discussion