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ABCA2 Gene - ATP Binding Cassette Subfamily A Member 2

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slug	genes-abca2
entity_type	gene
kg_node_id	ABCA2

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see_also📖LX1001 Phase 1/2 Trial (NCT03634007) - Gene Therapy for APOE75%

see_also📖LX1001 Long-Term Follow-up (NCT05400330) - Gene Therapy for 75%

see_also📖nct0550878975%

see_also📖remternetug-anti-amyloid-alzheimers75%

see_also📖UPenn Observational Research Repository (NCT04715399)75%

mentions🧪Selective APOE4 Degradation via Proteolysis Targeting Chimer70%

mentions🧪APOE Isoform Conversion Therapy70%

mentions🧪APOE4 Allosteric Rescue via Small Molecule Chaperones70%

mentions🧪Interfacial Lipid Mimetics to Disrupt Domain Interaction70%

mentions🧪Targeted APOE4-to-APOE3 Base Editing Therapy70%

mentions🧪Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides70%

mentions🧪APOE4-Selective Lipid Nanoemulsion Therapy70%

mentions🧪Competitive APOE4 Domain Stabilization Peptides70%

mentions🧪APOE Isoform Expression Across Glial Subtypes70%

see_also📖BEACoN Study - Biomarker Exploration in Aging, Cognition and70%

see_also📖ALA-enriched Nutrition for APOE4 Carriers with MCI (NCT0739270%

see_also📖APOE2 (Apolipoprotein E2)70%

see_also📖APOE3 (Apolipoprotein E3)70%

see_also📖APOE4 (Apolipoprotein E4)70%

see_also📖Cell-Free DNA Biomarkers in Neurodegeneration60%

see_also📖Exosomal Biomarkers in Neurodegeneration60%

see_also📖Exosomal miR-155 in Neurodegeneration60%

see_also📖IL-6 (Interleukin-6) in Neurodegeneration60%

see_also📖Liquid Biopsy in Neurodegeneration60%

see_also📖Metabolomic Biomarkers in Neurodegeneration60%

see_also📖Neuroimaging Biomarkers for Neurodegeneration60%

see_also📖Synaptic Biomarkers in Neurodegeneration60%

see_also📖Olfactory Mucosa, Blood and Urine for Identification of Earl60%

see_also📖Swedish BioFINDER 2 Study: Biomarkers and Neurodegeneration 60%

see_also📖Beta-Propeller Protein-Associated Neurodegeneration (BPAN)60%

see_also📖China Neurodegeneration Epidemiology60%

see_also📖DALY Methodology — Neurodegeneration60%

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see_also📖European Neurodegeneration Epidemiology60%

see_also📖Familial vs Sporadic Neurodegeneration Comparison60%

see_also📖Global Neurodegeneration Epidemiology60%

see_also📖India Neurodegeneration Epidemiology60%

see_also📖Japan Neurodegeneration Epidemiology60%

see_also📖Manganese-Related Neurodegeneration (Manganism)60%

see_also📖mitochondrial-dysfunction-neurodegeneration-comparison60%

see_also📖Mitochondrial Diseases and Neurodegeneration Comparison Matr60%

see_also📖Mitochondrial Membrane Protein-Associated Neurodegeneration 60%

see_also📖Neurodegeneration with Brain Iron Accumulation (NBIA)60%

see_also📖Potential Impact Measures — Neurodegeneration60%

see_also📖Pantothenate Kinase-Associated Neurodegeneration (PKAN)60%

see_also📖PLA2G6-Associated Neurodegeneration (PLAN)60%

see_also📖Sleep Disorders in Neurodegeneration60%

see_also📖US Neurodegeneration Epidemiology60%

see_also📖Extracellular Vesicle and Tunneling Nanotube-Mediated Spread60%

see_also📖acetylcholine-signaling-neurodegeneration60%

see_also📖Advanced Glycation End Products in Neurodegeneration60%

see_also📖Advanced In Vitro Models for Neurodegeneration — Organoids, 60%

see_also📖Amylin Signaling in Neurodegeneration60%

see_also📖Antibody Therapy in Neurodegeneration60%

see_also📖Antisense Oligonucleotide (ASO) Therapy in Neurodegeneration60%

see_also📖Autosis Pathway in Neurodegeneration60%

see_also📖Axon Guidance Pathways in Neurodegeneration60%

see_also📖Basal Ganglia Circuit Dysfunction in Neurodegeneration60%

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see_also📖CaMKII Signaling Pathway in Neurodegeneration60%

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see_also📖Cerebral Amyloid Angiopathy in Neurodegeneration60%

see_also📖Cerebral Amyloid Angiopathy Pathway in Neurodegeneration60%

see_also📖Cholinergic System Dysfunction in Neurodegeneration60%

see_also📖Chrononutrition and Time-Restricted Eating in Neurodegenerat60%

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see_also📖Cognitive Reserve and Resilience in Neurodegeneration60%

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see_also📖Convergent Pathways in Neurodegeneration60%

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see_also📖Diffusion MRI (DTI) in Neurodegeneration60%

see_also📖Digital Phenotyping in Neurodegeneration60%

see_also📖Down Syndrome Neurodegeneration Pathway60%

see_also📖Dystrophic Neurites in Neurodegeneration60%

see_also📖Endocannabinoid System in Neurodegeneration60%

see_also📖Endosomal-Lysosomal Pathway in Neurodegeneration60%

see_also📖Endosomal Sorting Defects in Neurodegeneration60%

see_also📖Endothelin Signaling Pathway in Neurodegeneration60%

see_also📖epigenetics-neurodegeneration60%

see_also📖ESCRT-III Inhibition by Alpha-Synuclein in Neurodegeneration60%

see_also📖FA2H-Associated Neurodegeneration Pathway60%

see_also📖Farnesoid X Receptor (FXR) Signaling in Neurodegeneration60%

see_also📖Galectin-3 Mechanism in Neurodegeneration60%

see_also📖Gangliosides in Neurodegeneration60%

see_also📖GDF15/GDF11 Signaling in Neurodegeneration60%

see_also📖GDNF Signaling Pathway in Neurodegeneration60%

see_also📖Ghrelin Signaling Pathway in Neurodegeneration60%

see_also📖Glucocorticoid Signaling Pathway in Neurodegeneration60%

see_also📖Glycosylation in Neurodegeneration60%

see_also📖gp130/IL-6 Family Cytokine Signaling in Neurodegeneration60%

see_also📖Hippocampal Neurogenesis in Neurodegeneration60%

see_also📖Histone Modification Pathways in Neurodegeneration60%

see_also📖HMGB1 Signaling in Neurodegeneration60%

see_also📖Homocysteine Neurotoxicity and Neurodegeneration60%

see_also📖IGF-1 Signaling Pathway in Neurodegeneration60%

see_also📖IL-1 Signaling Pathway in Neurodegeneration60%

see_also📖Integrated Stress Response in Neurodegeneration60%

see_also📖interleukin-6-signaling-neurodegeneration60%

see_also📖Intrinsic Apoptosis Pathway in Neurodegeneration60%

see_also📖Ion Channel Dysfunction in Neurodegeneration: Cross-Disease 60%

see_also📖Kidney-Brain Neurodegeneration Axis60%

see_also📖Lipid Dysregulation in Neurodegeneration60%

see_also📖Lipid Metabolism Dysregulation in Neurodegeneration60%

see_also📖Lysosomal Calcium Dysregulation in Neurodegeneration60%

see_also📖Magnetic Resonance Spectroscopy in Neurodegeneration60%

see_also📖Metal Homeostasis Dysregulation in Neurodegeneration60%

see_also📖Metal Homeostasis in Neurodegeneration60%

see_also📖Microglial Priming Pathway in Neurodegeneration60%

see_also📖MicroRNA Dysfunction in Neurodegeneration60%

see_also📖Mineralocorticoid Receptor Signaling in Neurodegeneration60%

see_also📖Mitochondrial Dynamics Pathway in Neurodegeneration60%

see_also📖Mitochondrial Fusion in Neurodegeneration60%

see_also📖Molecular Chaperones in Neurodegeneration60%

see_also📖mTOR Signaling in Neurodegeneration60%

see_also📖mTOR Signaling Pathway in Neurodegeneration60%

see_also📖Neural Circuit Disruption in Neurodegeneration60%

see_also📖Neurexin/Neuroligin Synaptic Adhesion Modulator Therapy in N60%

see_also📖Neurofilament Light Chain (NfL) Mechanism in Neurodegenerati60%

see_also📖Neuronal Hyperexcitability in Neurodegeneration60%

see_also📖Neuropil Threads in Neurodegeneration60%

see_also📖Neurotensin Signaling in Neurodegeneration60%

see_also📖Neurovascular Unit Dysfunction in Neurodegeneration60%

see_also📖NF-kB Signaling Pathway in Neurodegeneration60%

see_also📖Nitric Oxide Signaling in Neurodegeneration60%

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see_also📖NRF2 Signaling Pathway in Neurodegeneration60%

see_also📖Nuclear Pore Complex Dysfunction in Neurodegeneration60%

see_also📖Orexin Signaling in Neurodegeneration60%

see_also📖OSK Reprogramming and Yamanaka Factors in Neurodegeneration60%

see_also📖P-Body (Processing Body) Pathway in Neurodegeneration60%

see_also📖Paranodal Dysfunction in Neurodegeneration60%

see_also📖Paraptosis in Neurodegeneration60%

see_also📖Parthanatos in Neurodegeneration60%

see_also📖Pericyte Loss in Neurodegeneration60%

see_also📖Peripheral Immune-Brain Crosstalk in Neurodegeneration60%

see_also📖PKR Pathway in Neurodegeneration60%

see_also📖PPAR Signaling Pathway in Neurodegeneration60%

see_also📖Prion Diseases in Neurodegeneration60%

see_also📖Prion-Like Spread in Neurodegeneration60%

see_also📖Prion Protein Metabolism in Neurodegeneration60%

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see_also📖Protein Aggregation Comparison in Neurodegeneration60%

see_also📖Protein Aggregation Seeds in Neurodegeneration60%

see_also📖Protein O-GlcNAcylation Pathway in Neurodegeneration60%

see_also📖Cortical Involvement and Neurodegeneration in Progressive Su60%

see_also📖Purinergic Signaling in Neurodegeneration60%

see_also📖Quantum Biology and Coherent Energy Transfer in Neurodegener60%

see_also📖R-Loop Stress in Neurodegeneration60%

see_also📖RAN Translation in Neurodegeneration60%

see_also📖Retinal Degeneration Pathway in Neurodegeneration60%

see_also📖Ribosome Dysfunction in Neurodegeneration60%

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see_also📖S100 Protein Signaling Pathway in Neurodegeneration60%

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see_also📖Serotonergic Dysfunction in Neurodegeneration60%

see_also📖Sex Differences in Neurodegeneration60%

see_also📖Short Chain Fatty Acids in Neurodegeneration60%

see_also📖Sigma-1 Receptor Signaling in Neurodegeneration60%

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see_also📖SUMOylation in Neurodegeneration60%

see_also📖synaptic-vesicle-cycling-neurodegeneration60%

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see_also📖Transdiagnostic Proteomic Changes in Neurodegeneration60%

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see_also📖vip-vasoactive-intestinal-peptide-signaling-neurodegeneratio60%

see_also📖WNK1-Bilirubin Signaling in Neuroinflammation and Neurodegen60%

see_also📖Wnt/β-Catenin Signaling Pathway in Neurodegeneration60%

see_also📖ABCA1 - ATP-Binding Cassette Transporter A160%

see_also📖APOA1 Gene60%

see_also📖APOC1 Gene — Apolipoprotein C-I60%

see_also📖APOC2 Gene60%

see_also📖APOC3 Gene60%

see_also📖apoe60%

see_also📖CYP46A1 — Cholesterol 24-Hydroxylase60%

see_also📖LDLR Gene60%

see_also📖LRP1 Gene60%

see_also📖LRP8 Gene60%

see_also📖hypotheses-apoe-contributes-alzheimers-disease-regulat60%

see_also📖LRP1-Targeted ApoE-Mimetic Peptide Delivery60%

see_also📖LRP1-Enhanced Perivascular Drainage Therapy60%

see_also📖ApoE (Apolipoprotein E)60%

see_also📖LRP1 (Low-Density Lipoprotein Receptor-Related Protein 1)60%

see_also📖p-tau60%

see_also📖Total Tau (t-Tau) - Biomarker60%

see_also📖Tau Pathology Astrocytes (TPA)60%

see_also📖tau-pet-4r-tauopathies60%

see_also📖entities-psen160%

see_also📖entities-psen260%

see_also📖Tau Oligomers60%

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see_also📖Tau Co-Pathology in DLB Clinical Heterogeneity60%

see_also📖Tau ASO Therapy60%

see_also📖Tau vs TDP-43 Fate Switching in Frontotemporal Dementia60%

see_also📖app60%

see_also📖mapt60%

see_also📖NCSTN Gene - Nicastrin60%

see_also📖SREBF1 Gene60%

see_also📖Tau Pathology Severity Assessment Model — Braak Staging and 60%

see_also📖Tau-Seed Interception Using Conformational-Selective Extrace60%

see_also📖APP Gene Dosage Reduction Therapy for Down Syndrome60%

see_also📖Tau-PROTAC Heterobifunctional Degrader for Tauopathy60%

see_also📖Alzheimer Indonesia60%

see_also📖Packard Center for ALS Research60%

see_also📖Tau Proteostasis and Clearance Across 4R-Tauopathies60%

see_also📖Epidemic Spreading Model of Tau Pathology60%

see_also📖Granulovacuolar Bodies: Neuronal Defense Mechanism Against T60%

see_also📖oga-inhibition-tau60%

see_also📖Tau Consortium60%

see_also📖APP Protein60%

see_also📖GSK3B (Glycogen Synthase Kinase 3 Beta)60%

see_also📖GSK3B Protein** is a protein. This page describes its struct60%

see_also📖Tau Protein60%

see_also📖Advanced Immunotherapy Platforms for Tau60%

see_also📖Phage Display and Directed Evolution for Tau Therapeutics60%

see_also📖Neurons in Dentatorubral-Pallidoluysian Atrophy60%

see_also📖Hippocampal CA1 Pyramidal Neurons60%

see_also📖Neurons in Lysosomal Storage Disorders with Neurodegeneratio60%

see_also📖Neurons60%

see_also📖Neurons — Cell Type Hierarchy60%

see_also📖Neurons in Normal Pressure Hydrocephalus60%

see_also📖Neurons in Prion Disease60%

see_also📖Neurons in Spinocerebellar Ataxia Type 3 (Machado-Joseph Dis60%

see_also📖Neurons Susceptible to Viral Infection60%

see_also📖Neurons in Wilson Disease60%

see_also📖Neurons60%

see_also📖ABCD3 Gene60%

see_also📖ABCG1 Gene60%

see_also📖ABCG2 (BCRP) - ATP Binding Cassette Subfamily G Member 260%

see_also📖ATP7A60%

see_also📖slc22a560%

see_also📖ABCD3 Protein60%

see_also📖gsk3b60%

see_also📖LIPA Gene60%

see_also📖PSEN2 — Presenilin 260%

see_also📖PSEN2 Protein (Presenilin-2)60%

see_also📖Genes60%

see_also📖PSEN1 — Presenilin 160%

see_also📖PSEN1 Protein (Presenilin-1)60%

see_also📖Adipose-Derived Mesenchymal Stem Cell Therapy for Early Alzh55%

see_also📖NCT07477431 - Levetiracetam for Persons at Risk for Alzheime55%

see_also📖TRAILRUNNER-ALZ 1: Remternetug for Early Alzheimer's Di55%

mentions🧪CYP46A1 Overexpression Gene Therapy50%

mentions🧪Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th50%

see_also📖al002-trem2-agonist-alzheimers50%

see_also📖CORT108297 Phase 2 (NCT04601038) - Stress Attenuation in AD50%

see_also📖DBS Nucleus Basalis Trial (NCT07218081): Deep Brain Stimulat50%

see_also📖Donanemab TRAILBLAZER-ALZ 2 Trial50%

see_also📖MK-1167 Phase 2 AD Trial (MK-1167-008)50%

see_also📖A Placebo-Controlled, Double-Blind, Parallel-Group, 18-Month50%

see_also📖A Phase IIB, Randomized, Double-Blind, Placebo-Controlled, M50%

see_also📖A Phase 2 Double-Blind, Randomized, Placebo-Controlled Trial50%

see_also📖Trontinemab (RO7126209) Phase 3 Trial — TRONTIER 2 (NCT0717050%

see_also📖UB-311 Alzheimer's Vaccination Trial50%

see_also📖Cannabidiol for Alzheimer's Disease Prevention (NCT058245%

see_also📖EI-1071 Immunomodulator for Alzheimer's Disease (NCT06745%

mentions🔬What are the mechanisms underlying rna binding protein dysre40%

mentions🔬APOE4 differs from APOE3 by C112R causing domain interaction40%

mentions🔬RNA binding protein dysregulation across ALS FTD and AD40%

mentions🔬Analyze circuit-level changes in neurodegeneration using All40%

related🧪APOE Isoform Conversion Therapy40%