GAP43-mediated tunneling nanotube stabilization enhances neuroprotective mitochondrial transfer

**Molecular Mechanism and Rationale** The growth-associated protein 43 (GAP43) represents a critical nexus in neuronal plasticity and cytoskeletal dynamics, making it an ideal candidate for enhancing intercellular mitochondrial transfer mechanisms. GAP43 is a membrane-associated phosphoprotein that localizes primarily to growth cones and presynaptic terminals, where it regulates actin polymerization through its interaction with calmodulin and protein kinase C (PKC). In the context of tunneling ...