Palmitoylation-Targeted BACE1 Trafficking Disruptors

**Molecular Mechanism and Rationale** The therapeutic approach targeting BACE1 palmitoylation represents a sophisticated strategy to modulate amyloid-beta (Aβ) production by disrupting the subcellular localization of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) without compromising its enzymatic activity or global protein palmitoylation processes. BACE1, a transmembrane aspartyl protease, undergoes post-translational modification through palmitoylation at specific cysteine residue...