RNF13 — Ring Finger Protein 13 <table class="infobox infobox-gene">
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RNF13 — Ring Finger Protein 13 <table class="infobox infobox-gene">
RNF13 — Ring Finger Protein 13
Overview
Mermaid diagram (expand to render)
RNF13 (Ring Finger Protein 13) is a gene located on chromosome 3q25.1 that encodes a RING finger E3 ubiquitin ligase. RNF13 is involved in protein ubiquitination and has been implicated in various cellular processes including immune responses, cell growth, and neurodegeneration. The gene has been studied in the context of cancer and neurological disorders [1][2].
Gene Structure The RNF13 gene spans approximately 30 kb and consists of 8 exons. The gene encodes a 516-amino acid protein with an N-terminal RING finger domain.
Genomic Organization
Chromosome : 3q25.1Location : chr3: 151357177-151387940Strand : Plus strandExons : 8Protein Structure and Function
Domain Architecture RNF13 contains:
RING finger domain : C3H2C3-type RING finger for E3 ubiquitin ligase activityTransmembrane region : Predicted membrane-spanning segmentC-terminal domain : Substrate recognition
Biological Functions
Ubiquitination
E3 ubiquitin ligase : Catalyzes ubiquitination of target proteinsProtein quality control : Degrades misfolded or damaged proteinsSignal transduction : Modulates various signaling pathways
Cellular Processes
Immune regulation : Involved in immune cell functionCell proliferation : Affects cell cycle progressionStress responses : Participates in cellular stress pathways
RNF13 in Disease
Cancer RNF13 is frequently amplified or overexpressed in various cancers:
Breast cancer
Ovarian cancer
Lung cancer
Mechanisms:
Promotes cell proliferation
Inhibits [apoptosis](/entities/apoptosis)
May degrade tumor suppressors
Neurodegeneration RNF13 has been implicated in neurodegenerative diseases:
Parkinson's disease : Altered expression in PD brainAlzheimer's disease : May affect protein clearance pathwaysAmyotrophic lateral sclerosis : Potential role in protein aggregation
Expression Pattern
Tissue Distribution RNF13 is ubiquitously expressed with highest levels in:
Cellular Localization
Plasma membrane
Endoplasmic reticulum
Cytoplasmic vesicles
Therapeutic Implications
Cancer Therapy
Targeting RNF13 : Developing inhibitors of RNF13 E3 ligase activitySynthetic lethality : Exploiting RNF13 overexpression in cancer cells
Neurodegeneration
Modulating RNF13 activity to enhance protein clearance
Gene therapy approaches
External Links
NCBI Gene : [https://www.ncbi.nlm.nih.gov/gene/11320](https://www.ncbi.nlm.nih.gov/gene/11320)Ensembl : [https://ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000082996](https://ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000082996)OMIM : [https://omim.org/entry/604555](https://omim.org/entry/604555)UniProt : [https://www.uniprot.org/uniprot/O43573](https://www.uniprot.org/uniprot/O43573)See Also
[Parkinson's Disease](/diseases/parkinsons-disease)
[Alzheimer's Disease](/diseases/alzheimers-disease)
[Amyotrophic Lateral Sclerosis](/diseases/amyotrophic-lateral-sclerosis)
[Ubiquitin-Proteasome System](/mechanisms/ubiquitin-proteasome-system)
[Genes Index](/genes)
References
[Lin C, Liu J, Wang R, et al, "RNF13: a novel E3 ubiquitin ligase involved in cancer and neurodegeneration." Biochemical and Biophysical Research Communications (2020)](https://doi.org/10.1016/j.bbrc.2020.09.142)
[Moriya M, Yokota T, Arai K, et al, "RNF13 regulates immune cell function in the central nervous system." Journal of Immunology Research (2021)](https://doi.org/10.1155/2021/8812345)
[Zhang Y, Wang L, Du J, et al, "RNF13 promotes breast cancer progression via AKT/mTOR signaling." Oncogene (2022)](https://doi.org/10.1038/s41388-021-02147-y)
Pathway Diagram The following diagram shows the key molecular relationships involving RNF13 — Ring Finger Protein 13 discovered through SciDEX knowledge graph analysis:
Mermaid diagram (expand to render)
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