gene

RNF13

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RNF13: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

16Connections

0Hypotheses

0Analyses

10Outgoing

6Incoming

0Experiments

Summary

RNF13 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, therapeutic target, implicated in. Associated with Ischemia, Ms, Stroke. Connected to 17 entities in the SciDEX knowledge graph.

View on Wiki →

🧬 Gene Info

Gene Symbol	RNF13
Full Name	Ring Finger Protein 13
Chromosome	3q25.1
Protein Type	Ligase
Function	is a gene located on chromosome 3q25.
Primary Expression	Ubiquitously expressed; high expression in brain, heart, lung
Amino Acids	516 aa
Exons	8
UniProt ID	O43573
NCBI Gene ID	11320
Ensembl ID	ENSG00000082996
OMIM	604555
GeneCards	RNF13
Human Protein Atlas	RNF13
Associated Diseases	Ms
Interactions	NRF2, P62, APOPTOSIS, TRIM21, HO-1, AUTOPHAGY
KG Connections	16 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: RNF13 — AlphaFold O43573 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    RNF13["<b>RNF13</b>"]
    Ischemia{"Ischemia"}
    RNF13 -->|"therapeutic target"| Ischemia
    Ms{"Ms"}
    RNF13 -->|"associated with"| Ms
    Stroke{"Stroke"}
    RNF13 -->|"therapeutic target"| Stroke
    Apoptosis(["Apoptosis"])
    RNF13 -->|"inhibits"| Apoptosis
    Autophagy(["Autophagy"])
    RNF13 -->|"inhibits"| Autophagy
    neurodegeneration["neurodegeneration"]
    RNF13 -->|"implicated in"| neurodegeneration
    P62["P62"]
    P62 -->|"inhibits"| RNF13
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"inhibits"| RNF13
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"inhibits"| RNF13
    HO_1["HO-1"]
    HO_1 -->|"inhibits"| RNF13
    NRF2["NRF2"]
    NRF2 -->|"inhibits"| RNF13
    style RNF13 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (10)

Target	Relation	Type	Str
Ischemia	therapeutic_target	disease	0.65
Ms	associated_with	disease	0.65
Stroke	therapeutic_target	disease	0.65
NRF2	inhibits	gene	0.60
P62	inhibits	gene	0.60
Apoptosis	inhibits	pathway	0.60
Autophagy	inhibits	pathway	0.60
APOPTOSIS	inhibits	gene	0.60
TRIM21	inhibits	gene	0.60
HO-1	inhibits	gene	0.60

Incoming (6)

Source	Relation	Type	Str
P62	inhibits	gene	0.60
NRF2	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
HO-1	inhibits	gene	0.60
STROKE	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found