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ABCA7 Protein

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slug	proteins-abca7-protein
entity_type	protein
kg_node_id	ABCA7PROTEIN

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Linked Artifacts (235)

mentions🧪Selective APOE4 Degradation via Proteolysis Targeting Chimer70%

mentions🧪APOE Isoform Conversion Therapy70%

mentions🧪APOE4 Allosteric Rescue via Small Molecule Chaperones70%

mentions🧪Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides70%

mentions🧪Interfacial Lipid Mimetics to Disrupt Domain Interaction70%

mentions🧪Membrane Cholesterol Gradient Modulators70%

related🧪Selective APOE4 Degradation via Proteolysis Targeting Chimer63%

related🧪APOE Isoform Conversion Therapy63%

related🧪APOE4 Allosteric Rescue via Small Molecule Chaperones63%

related🧪Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides63%

related🧪Interfacial Lipid Mimetics to Disrupt Domain Interaction63%

related🧪Membrane Cholesterol Gradient Modulators63%

see_also📖BEACoN Study - Biomarker Exploration in Aging, Cognition and60%

see_also📖Neurodegeneration60%

see_also📖Cell-Free DNA Biomarkers in Neurodegeneration55%

see_also📖Exosomal Biomarkers in Neurodegeneration55%

see_also📖Exosomal miR-155 in Neurodegeneration55%

see_also📖IL-6 (Interleukin-6) in Neurodegeneration55%

see_also📖Liquid Biopsy in Neurodegeneration55%

see_also📖Metabolomic Biomarkers in Neurodegeneration55%

see_also📖Neuroimaging Biomarkers for Neurodegeneration55%

see_also📖Synaptic Biomarkers in Neurodegeneration55%

see_also📖LX1001 Phase 1/2 Trial (NCT03634007) - Gene Therapy for APOE55%

see_also📖LX1001 Long-Term Follow-up (NCT05400330) - Gene Therapy for 55%

see_also📖nct0550878955%

see_also📖ALA-enriched Nutrition for APOE4 Carriers with MCI (NCT0739255%

see_also📖Olfactory Mucosa, Blood and Urine for Identification of Earl55%

see_also📖remternetug-anti-amyloid-alzheimers55%

see_also📖Swedish BioFINDER 2 Study: Biomarkers and Neurodegeneration 55%

see_also📖UPenn Observational Research Repository (NCT04715399)55%

see_also📖APOE2 (Apolipoprotein E2)55%

see_also📖APOE3 (Apolipoprotein E3)55%

see_also📖APOE4 (Apolipoprotein E4)55%

see_also📖Beta-Propeller Protein-Associated Neurodegeneration (BPAN)55%

see_also📖China Neurodegeneration Epidemiology55%

see_also📖DALY Methodology — Neurodegeneration55%

see_also📖Disease Progression & Staging in Neurodegeneration55%

see_also📖Economic Burden — Neurodegeneration55%

see_also📖European Neurodegeneration Epidemiology55%

see_also📖Familial vs Sporadic Neurodegeneration Comparison55%

see_also📖Global Neurodegeneration Epidemiology55%

see_also📖India Neurodegeneration Epidemiology55%

see_also📖Japan Neurodegeneration Epidemiology55%

see_also📖Manganese-Related Neurodegeneration (Manganism)55%

see_also📖mitochondrial-dysfunction-neurodegeneration-comparison55%

see_also📖Mitochondrial Diseases and Neurodegeneration Comparison Matr55%

see_also📖Mitochondrial Membrane Protein-Associated Neurodegeneration 55%

see_also📖Neurodegeneration with Brain Iron Accumulation (NBIA)55%

see_also📖Potential Impact Measures — Neurodegeneration55%

see_also📖Pantothenate Kinase-Associated Neurodegeneration (PKAN)55%

see_also📖PLA2G6-Associated Neurodegeneration (PLAN)55%

see_also📖Sleep Disorders in Neurodegeneration55%

see_also📖US Neurodegeneration Epidemiology55%

see_also📖Extracellular Vesicle and Tunneling Nanotube-Mediated Spread55%

see_also📖acetylcholine-signaling-neurodegeneration55%

see_also📖Advanced Glycation End Products in Neurodegeneration55%

see_also📖Advanced In Vitro Models for Neurodegeneration — Organoids, 55%

see_also📖Amylin Signaling in Neurodegeneration55%

see_also📖Antibody Therapy in Neurodegeneration55%

see_also📖Antisense Oligonucleotide (ASO) Therapy in Neurodegeneration55%

see_also📖Autosis Pathway in Neurodegeneration55%

see_also📖Axon Guidance Pathways in Neurodegeneration55%

see_also📖Basal Ganglia Circuit Dysfunction in Neurodegeneration55%

see_also📖becn1-autophagy-initiation-neurodegeneration-causal-chain55%

see_also📖CaMKII Signaling Pathway in Neurodegeneration55%

see_also📖Carbonic Anhydrase Modulator Therapy in Neurodegeneration55%

see_also📖Cerebral Amyloid Angiopathy in Neurodegeneration55%

see_also📖Cerebral Amyloid Angiopathy Pathway in Neurodegeneration55%

see_also📖Cholinergic System Dysfunction in Neurodegeneration55%

see_also📖Chrononutrition and Time-Restricted Eating in Neurodegenerat55%

see_also📖Neural Circuits in Neurodegeneration55%

see_also📖Cognitive Reserve and Resilience in Neurodegeneration55%

see_also📖Computational Disease Models for Neurodegeneration55%

see_also📖Convergent Pathways in Neurodegeneration55%

see_also📖Copper Homeostasis in Neurodegeneration55%

see_also📖COVID-19 Neurodegeneration Mechanism55%

see_also📖Diffusion MRI (DTI) in Neurodegeneration55%

see_also📖Digital Phenotyping in Neurodegeneration55%

see_also📖Down Syndrome Neurodegeneration Pathway55%

see_also📖Dystrophic Neurites in Neurodegeneration55%

see_also📖Endocannabinoid System in Neurodegeneration55%

see_also📖Endosomal-Lysosomal Pathway in Neurodegeneration55%

see_also📖Endosomal Sorting Defects in Neurodegeneration55%

see_also📖Endothelin Signaling Pathway in Neurodegeneration55%

see_also📖epigenetics-neurodegeneration55%

see_also📖ESCRT-III Inhibition by Alpha-Synuclein in Neurodegeneration55%

see_also📖FA2H-Associated Neurodegeneration Pathway55%

see_also📖Farnesoid X Receptor (FXR) Signaling in Neurodegeneration55%

see_also📖Galectin-3 Mechanism in Neurodegeneration55%

see_also📖Gangliosides in Neurodegeneration55%

see_also📖GDF15/GDF11 Signaling in Neurodegeneration55%

see_also📖GDNF Signaling Pathway in Neurodegeneration55%

see_also📖Ghrelin Signaling Pathway in Neurodegeneration55%

see_also📖Glucocorticoid Signaling Pathway in Neurodegeneration55%

see_also📖Glycosylation in Neurodegeneration55%

see_also📖gp130/IL-6 Family Cytokine Signaling in Neurodegeneration55%

see_also📖Hippocampal Neurogenesis in Neurodegeneration55%

see_also📖Histone Modification Pathways in Neurodegeneration55%

see_also📖HMGB1 Signaling in Neurodegeneration55%

see_also📖Homocysteine Neurotoxicity and Neurodegeneration55%

see_also📖IGF-1 Signaling Pathway in Neurodegeneration55%

see_also📖IL-1 Signaling Pathway in Neurodegeneration55%

see_also📖Integrated Stress Response in Neurodegeneration55%

see_also📖interleukin-6-signaling-neurodegeneration55%

see_also📖Intrinsic Apoptosis Pathway in Neurodegeneration55%

see_also📖Ion Channel Dysfunction in Neurodegeneration: Cross-Disease 55%

see_also📖Kidney-Brain Neurodegeneration Axis55%

see_also📖Lipid Dysregulation in Neurodegeneration55%

see_also📖Lipid Metabolism Dysregulation in Neurodegeneration55%

see_also📖Lysosomal Calcium Dysregulation in Neurodegeneration55%

see_also📖Magnetic Resonance Spectroscopy in Neurodegeneration55%

see_also📖Metal Homeostasis Dysregulation in Neurodegeneration55%

see_also📖Metal Homeostasis in Neurodegeneration55%

see_also📖Microglial Priming Pathway in Neurodegeneration55%

see_also📖MicroRNA Dysfunction in Neurodegeneration55%

see_also📖Mineralocorticoid Receptor Signaling in Neurodegeneration55%

see_also📖Mitochondrial Dynamics Pathway in Neurodegeneration55%

see_also📖Mitochondrial Fusion in Neurodegeneration55%

see_also📖Molecular Chaperones in Neurodegeneration55%

see_also📖mTOR Signaling in Neurodegeneration55%

see_also📖mTOR Signaling Pathway in Neurodegeneration55%

see_also📖Neural Circuit Disruption in Neurodegeneration55%

see_also📖Neurexin/Neuroligin Synaptic Adhesion Modulator Therapy in N55%

see_also📖Neurofilament Light Chain (NfL) Mechanism in Neurodegenerati55%

see_also📖Neuronal Hyperexcitability in Neurodegeneration55%

see_also📖Neuropil Threads in Neurodegeneration55%

see_also📖Neurotensin Signaling in Neurodegeneration55%

see_also📖Neurovascular Unit Dysfunction in Neurodegeneration55%

see_also📖NF-kB Signaling Pathway in Neurodegeneration55%

see_also📖Nitric Oxide Signaling in Neurodegeneration55%

see_also📖Noradrenergic Signaling Pathway in Neurodegeneration55%

see_also📖Neuropeptide Y Signaling in Neurodegeneration55%

see_also📖NRF2 Signaling Pathway in Neurodegeneration55%

see_also📖Nuclear Pore Complex Dysfunction in Neurodegeneration55%

see_also📖Orexin Signaling in Neurodegeneration55%

see_also📖OSK Reprogramming and Yamanaka Factors in Neurodegeneration55%

see_also📖P-Body (Processing Body) Pathway in Neurodegeneration55%

see_also📖Paranodal Dysfunction in Neurodegeneration55%

see_also📖Paraptosis in Neurodegeneration55%

see_also📖Parthanatos in Neurodegeneration55%

see_also📖Pericyte Loss in Neurodegeneration55%

see_also📖Peripheral Immune-Brain Crosstalk in Neurodegeneration55%

see_also📖PKR Pathway in Neurodegeneration55%

see_also📖PPAR Signaling Pathway in Neurodegeneration55%

see_also📖Prion Diseases in Neurodegeneration55%

see_also📖Prion-Like Spread in Neurodegeneration55%

see_also📖Prion Protein Metabolism in Neurodegeneration55%

see_also📖Progesterone Signaling Pathway in Neurodegeneration55%

see_also📖Prognostic Biomarkers in Neurodegeneration55%

see_also📖Protein Aggregation Comparison in Neurodegeneration55%

see_also📖Protein Aggregation Seeds in Neurodegeneration55%

see_also📖Protein O-GlcNAcylation Pathway in Neurodegeneration55%

see_also📖Cortical Involvement and Neurodegeneration in Progressive Su55%

see_also📖Purinergic Signaling in Neurodegeneration55%

see_also📖Quantum Biology and Coherent Energy Transfer in Neurodegener55%

see_also📖R-Loop Stress in Neurodegeneration55%

see_also📖RAN Translation in Neurodegeneration55%

see_also📖Retinal Degeneration Pathway in Neurodegeneration55%

see_also📖Ribosome Dysfunction in Neurodegeneration55%

see_also📖RNA Splicing in Neurodegeneration55%

see_also📖RNA-Targeted Therapies in Neurodegeneration55%

see_also📖Ribonuclease κ and Circular RNAs: A New Mechanism of Aging a55%

see_also📖S100 Protein Signaling Pathway in Neurodegeneration55%

see_also📖Senescent Cell Clearance in Neurodegeneration55%

see_also📖Serotonergic Dysfunction in Neurodegeneration55%

see_also📖Sex Differences in Neurodegeneration55%

see_also📖Short Chain Fatty Acids in Neurodegeneration55%

see_also📖Sigma-1 Receptor Signaling in Neurodegeneration55%

see_also📖Sirtuin-Mitochondrial Biogenesis Axis in Neurodegeneration55%

see_also📖Sleep Dysfunction in Neurodegeneration55%

see_also📖SUMOylation in Neurodegeneration55%

see_also📖synaptic-vesicle-cycling-neurodegeneration55%

see_also📖Synthetic Lethality and PARP Inhibition in Neurodegeneration55%

see_also📖T-Cell Dysfunction in Neurodegeneration55%

see_also📖Tertiary Lymphoid Organs in Neurodegeneration55%

see_also📖Therapeutic Targets in Neurodegeneration55%

see_also📖Transdiagnostic Proteomic Changes in Neurodegeneration55%

see_also📖ubiquitin-proteasome-dysfunction-neurodegeneration55%

see_also📖Ubiquitin-Proteasome System Dysfunction in Neurodegeneration55%

see_also📖Vagus Nerve Pathway in Neurodegeneration55%

see_also📖VEGF Signaling and Cerebral Angiogenesis in Neurodegeneratio55%

see_also📖vip-vasoactive-intestinal-peptide-signaling-neurodegeneratio55%

see_also📖WNK1-Bilirubin Signaling in Neuroinflammation and Neurodegen55%

see_also📖Wnt/β-Catenin Signaling Pathway in Neurodegeneration55%

mentions🧪Targeted APOE4-to-APOE3 Base Editing Therapy50%

mentions🧪APOE4-Selective Lipid Nanoemulsion Therapy50%

mentions🧪Competitive APOE4 Domain Stabilization Peptides50%

mentions🧪APOE Isoform Expression Across Glial Subtypes50%

mentions🧪TREM2 Conformational Stabilizers for Synaptic Discrimination50%

mentions🧪APOE-TREM2 Interaction Modulation50%

mentions🧪TREM2-Mediated Selective Aggregate Clearance Pathway50%

mentions🧪TREM2-Dependent Microglial Senescence Transition50%

mentions🧪TREM2-mediated microglial tau clearance enhancement50%

mentions🧪Cell-Type Specific TREM2 Upregulation in DAM Microglia50%

mentions🧪Heat Shock Protein 70 Disaggregase Amplification50%

mentions🧪Serine/Arginine-Rich Protein Kinase Modulation50%

mentions🧪Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m50%

related🔬What are the mechanisms underlying tdp-43 phase separation t50%

related🔬What are the mechanisms underlying apoe4 structural biology 50%

related🔬Investigate how lipid raft composition (cholesterol metaboli50%

related🔬What are the mechanisms underlying mitochondrial transfer be50%

related🔬What are the mechanisms underlying tdp-43 phase separation t50%

related🔬What are the mechanisms underlying apoe4 structural biology 50%

related🔬What are the mechanisms underlying protein aggregation cross50%

related🔬Investigate how lipid raft composition (cholesterol metaboli50%

related🔬What are the mechanisms underlying rna binding protein dysre50%

related🔬What are the mechanisms underlying mitochondrial transfer be50%

related🔬Analyze circuit-level changes in neurodegeneration using All50%

related🔬RNA binding protein dysregulation across ALS FTD and AD50%

related🧪Selective APOE4 Degradation via Proteolysis Targeting Chimer50%

related🧪APOE Isoform Conversion Therapy50%

related🧪APOE4 Allosteric Rescue via Small Molecule Chaperones50%

related🧪FOXO3-Longevity Pathway Epigenetic Reprogramming50%

see_also📖Adipose-Derived Mesenchymal Stem Cell Therapy for Early Alzh50%

see_also📖al002-trem2-agonist-alzheimers50%

see_also📖CORT108297 Phase 2 (NCT04601038) - Stress Attenuation in AD50%

see_also📖DBS Nucleus Basalis Trial (NCT07218081): Deep Brain Stimulat50%

see_also📖Donanemab TRAILBLAZER-ALZ 2 Trial50%

see_also📖NCT07477431 - Levetiracetam for Persons at Risk for Alzheime50%

see_also📖MK-1167 Phase 2 AD Trial (MK-1167-008)50%

see_also📖A Placebo-Controlled, Double-Blind, Parallel-Group, 18-Month50%

see_also📖A Phase IIB, Randomized, Double-Blind, Placebo-Controlled, M50%

see_also📖TRAILRUNNER-ALZ 1: Remternetug for Early Alzheimer's Di50%

see_also📖A Phase 2 Double-Blind, Randomized, Placebo-Controlled Trial50%

see_also📖Trontinemab (RO7126209) Phase 3 Trial — TRONTIER 2 (NCT0717050%

see_also📖UB-311 Alzheimer's Vaccination Trial50%

mentions🔬What are the mechanisms underlying protein aggregation cross40%

mentions🔬What are the mechanisms underlying rna binding protein dysre40%

mentions🔬RNA binding protein dysregulation across ALS FTD and AD40%

mentions🔬Analyze circuit-level changes in neurodegeneration using All40%

related🧪Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m40%

related🧪Heat Shock Protein 70 Disaggregase Amplification40%

related🧪Serine/Arginine-Rich Protein Kinase Modulation40%