protein 2,826 words KG: ABCA7PROTEIN 2026-03-24
kind:proteinsection:proteinsstate:publishedevidence:strong
Contents

ABCA7 Protein

🔬 Protein Info
Gene SymbolABCA7
Full NameABCA7
Chromosome16p13.1
Protein TypeProtein
FunctionABCA7 encodes ATP-binding cassette transporter A7, a member of the ABC transporter family.
Primary Expressionimmune cells and the brain, where it plays important roles in lipid transport and cellular homeostasis
PathwaysCholesterol, Glycolysis, Immune Response, Lipid Metabolism, Nf-Κb
UniProt IDSearch UniProt
Ensembl IDENSG00000064687
GeneCardsABCA7
Human Protein AtlasABCA7
Associated DiseasesALZHEIMER'S DISEASE, Als, Alzheimer, Atherosclerosis
InteractionsNPY, CASS4, EPHA1, CLU, BIN1, CD33
KG Connections591 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (20)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Membrane Cholesterol Gradient Modulators
Score: 0.52
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.46

Related Analyses (8)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived

See Also (15)

BEACoN Study - Biomarker Exploration in Aging, Cognitio
clinical · Pages share 6 hypotheses
Neurodegeneration
disease · KG edge: implicated_in
Wnt/β-Catenin Signaling Pathway in Neurodegeneration
mechanism · Pages share 5 hypotheses
WNK1-Bilirubin Signaling in Neuroinflammation and Neuro
mechanism · Pages share 5 hypotheses
vip-vasoactive-intestinal-peptide-signaling-neurodegene
mechanism · Pages share 5 hypotheses