IFRD1 Protein - Interferon-Related Developmental Regulator 1

IFRD1 Protein - Interferon-Related Developmental Regulator 1

<table class="infobox infobox-protein">
<tr>
<th class="infobox-header" colspan="2">IFRD1 Protein — Interferon-Related Developmental Regulator 1</th>
</tr>
<tr>
<td class="label">Protein Name</td>
<td>Interferon-Related Developmental Regulator 1</td>
</tr>
<tr>
<td class="label">Gene</td>
<td><a href="/genes/ifrd1">IFRD1</a></td>
</tr>
<tr>
<td class="label">UniProt ID</td>
<td><a href="https://www.uniprot.org/uniprot/Q9UKV3" target="_blank">Q9UKV3</a></td>
</tr>
<tr>
<td class="label">Molecular Weight</td>
<td>~46 kDa (415 aa)</td>
</tr>
<tr>
<td class="label">Subcellular Localization</td>
<td>Nucleus, Cytoplasm</td>
</tr>
<tr>
<td class="label">Protein Family</td>
<td>IFRD family</td>
</tr>
<tr>
<td class="label">Expression</td>
<td>Brain, Spinal cord, Muscle, Heart</td>
</tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">1 edges</a></td>
</tr>
</table>

IFRD1 Protein — Interferon-Related Developmental Regulator 1

Introduction

Ifrd1 Protein Interferon Related Developmental Regulator 1 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

Overview

IFRD1 Protein - Interferon-Related Developmental Regulator 1

<table class="infobox infobox-protein">
<tr>
<th class="infobox-header" colspan="2">IFRD1 Protein — Interferon-Related Developmental Regulator 1</th>
</tr>
<tr>
<td class="label">Protein Name</td>
<td>Interferon-Related Developmental Regulator 1</td>
</tr>
<tr>
<td class="label">Gene</td>
<td><a href="/genes/ifrd1">IFRD1</a></td>
</tr>
<tr>
<td class="label">UniProt ID</td>
<td><a href="https://www.uniprot.org/uniprot/Q9UKV3" target="_blank">Q9UKV3</a></td>
</tr>
<tr>
<td class="label">Molecular Weight</td>
<td>~46 kDa (415 aa)</td>
</tr>
<tr>
<td class="label">Subcellular Localization</td>
<td>Nucleus, Cytoplasm</td>
</tr>
<tr>
<td class="label">Protein Family</td>
<td>IFRD family</td>
</tr>
<tr>
<td class="label">Expression</td>
<td>Brain, Spinal cord, Muscle, Heart</td>
</tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">1 edges</a></td>
</tr>
</table>

IFRD1 Protein — Interferon-Related Developmental Regulator 1

Introduction

Ifrd1 Protein Interferon Related Developmental Regulator 1 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

Overview

IFRD1 Protein (Interferon-Related Developmental Regulator 1) is a 415-amino acid protein involved in transcriptional regulation, cellular differentiation, and neuroprotection [1]. The protein is expressed in various tissues, with highest levels in the brain and spinal cord, particularly in [neurons](/entities/neurons) and motor neurons [2].

Structure

Domain Organization

• N-terminal Domain: Involved in protein-protein interactions
• Central Region: Regulatory domain
• C-terminal Domain: Transcriptional activation domain

Structural Features

• Nuclear Localization Signal: Contains NLS for nuclear import
• Transcription Activation Domain: Can activate transcription
• Protein Interaction Motifs: Multiple interaction domains

Function

Transcriptional Regulation

IFRD1 functions as a transcriptional co-activator:

• Chromatin Remodeling: Modifies histone acetylation
• Transcriptional Activation: Activates target gene expression
• Transcription Factor Recruitment: Recruits transcription factors to promoters

Cellular Functions

Role in Disease

Amyotrophic Lateral Sclerosis

IFRD1 is implicated in ALS [2]:

• Motor Neuron Expression: Highly expressed in motor neurons
• Disease Modifier: May influence ALS progression
• Therapeutic Target: Potential target for neuroprotection

Cancer

• Oncogenic Activity: Can promote tumor growth in some cancers
• Cell Proliferation: Stimulates cell proliferation
• Differentiation: Blocks cellular differentiation

Neurodegeneration

• Neuroprotective Effects: Protects neurons from various insults
• Stress Response: Enhances cellular stress tolerance
• Aging: May play role in age-related changes

Therapeutic Potential

Drug Development

• Gene Therapy: AAV-mediated IFRD1 delivery
• Small Molecule Modulators: Compounds that enhance IFRD1 activity
• Combination Therapy: With other neuroprotective agents

Biomarker Potential

• Disease Biomarker: IFRD1 levels may serve as biomarker
• Therapeutic Response: May predict treatment response

Interactions

Protein Interactions

• p53: Tumor suppressor, cell cycle regulation
• [NF-kB](/entities/nf-kb): Inflammation and stress response
• MyoD: Muscle differentiation
• [HDAC](/entities/hdac-enzymes) Complexes: Histone deacetylases

See Also

• [IFRD1 Gene](/genes/ifrd1)
• [ALS](/diseases/amyotrophic-lateral-sclerosis)
• [Motor Neurons](/cell-types/motor-neurons)
• [Neuroprotection](/therapeutics/neuroprotection)
• [Transcriptional Regulation](/mechanisms/transcription-regulation)

Background

The study of Ifrd1 Protein Interferon Related Developmental Regulator 1 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.

Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.

External Links

• [UniProt: Q9UKV3](https://www.uniprot.org/uniprot/Q9UKV3)
• [NCBI Protein: IFRD1](https://www.ncbi.nlm.nih.gov/protein/NP_001538)
• [Human Protein Atlas: IFRD1](https://www.proteinatlas.org/ENSG00000033178-IFRD1)

References