JNK3 Protein (c-Jun N-terminal Kinase 3)

JNK3 Protein (c-Jun N-terminal Kinase 3)

Overview

<table class="infobox infobox-protein">
<tr>
<th class="infobox-header" colspan="2">JNK3 Protein (c-Jun N-terminal Kinase 3)</th>
</tr>
<tr>
<td class="label">Symbol</td>
<td><strong>P53779</strong></td>
</tr>
<tr>
<td class="label">Full Name</td>
<td>JNK3 (c-Jun N-terminal Kinase 3)</td>
</tr>
<tr>
<td class="label">Type</td>
<td>Protein</td>
</tr>
<tr>
<td class="label">UniProt</td>
<td><a href="https://www.uniprot.org/uniprot/?query=P53779" target="_blank">Search UniProt</a></td>
</tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">1 edges</a></td>
</tr>
</table>

Jnk3 Protein (C Jun N Terminal Kinase 3) plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.

Introduction

Jnk3 Protein (C Jun N Terminal Kinase 3) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [@jnk2008]

JNK3 Protein (c-Jun N-terminal Kinase 3)

Overview

<table class="infobox infobox-protein">
<tr>
<th class="infobox-header" colspan="2">JNK3 Protein (c-Jun N-terminal Kinase 3)</th>
</tr>
<tr>
<td class="label">Symbol</td>
<td><strong>P53779</strong></td>
</tr>
<tr>
<td class="label">Full Name</td>
<td>JNK3 (c-Jun N-terminal Kinase 3)</td>
</tr>
<tr>
<td class="label">Type</td>
<td>Protein</td>
</tr>
<tr>
<td class="label">UniProt</td>
<td><a href="https://www.uniprot.org/uniprot/?query=P53779" target="_blank">Search UniProt</a></td>
</tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">1 edges</a></td>
</tr>
</table>

Jnk3 Protein (C Jun N Terminal Kinase 3) plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.

Introduction

Jnk3 Protein (C Jun N Terminal Kinase 3) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [@jnk2008]

.infobox-protein [@jnk1997]
!! colspan="2" style="background:#f8f9fa; text-align:center; font-weight:bold" | JNK3 Protein (c-Jun N-terminal Kinase 3) [@jnk2003]
|- [@jnk2006]
! Gene [@cjun2000]
| [MAPK10](/genes/mapk10) [@jnk2003a]
|- [@jnk2002]
! UniProt
| [P53779](https://www.uniprot.org/uniprot/P53779)
|-
! PDB Structures
| 1WMV, 2O0O, 4UX9, 5W5V
|-
! Molecular Weight
| ~46 kDa
|-
! Subcellular Localization
| Neuronal nucleus and cytoplasm
|-
! Protein Family
| MAP Kinase
|-

Structure

JNK3 is a serine/threonine kinase belonging to the MAPK family. It has a typical kinase domain structure with a hinge region connecting the N-terminal and C-terminal lobes. JNK3 has an extended C-terminal region and is primarily neuronal.

Normal Function

JNK3 is predominantly expressed in [neurons](/entities/neurons) and is activated by cellular stress, cytokines, and growth factors. It phosphorylates transcription factors including c-Jun, ATF2, and p53, regulating stress response, gene expression, and neuronal survival. JNK3 is involved in synaptic plasticity and memory formation.

Role in Disease

JNK3 activation promotes neuronal death in multiple neurodegenerative diseases. In AD, JNK3 is activated by [A-beta](/proteins/amyloid-beta) and contributes to [tau](/proteins/tau) phosphorylation and synaptic loss. In PD, JNK3 mediates MPTP-induced dopaminergic neuron death. In HD, mutant [huntingtin](/proteins/huntingtin) activates JNK3. JNK3 knockout mice are resistant to MPTP and excitotoxicity.

Therapeutic Targeting

JNK inhibitors have been investigated for neuroprotection. SP600125 and JNK-IN-8 are pan-JNK inhibitors. The challenge is achieving brain penetration while avoiding peripheral toxicity. Peptide inhibitors blocking JNK interactions are in development.

Key Publications

Overview

Jnk3 Protein (C Jun N Terminal Kinase 3) plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.

Background

The study of Jnk3 Protein (C Jun N Terminal Kinase 3) has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.

Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.

External Links

• [PubMed](https://pubmed.ncbi.nlm.nih.gov/) - Biomedical literature
• [Alzheimer's Disease Neuroimaging Initiative](https://adni.loni.usc.edu/) - Research data
• [Allen Brain Atlas](https://brain-map.org/) - Brain gene expression data

See Also

• [MAPK10 Gene](/genes/mapk10)
• [Proteins/P53779](/proteins/P53779)

References