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Allosteric vs. orthosteric**: Can PEN2 be targeted allosterically to achieve selectivity?
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open question
Created: 2026-04-25T20:29:19
By: backfill_open_questions
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ID: open_question-0beb8b78-109d-4be9-8a50-62
Open Question
open
Wiki: proteins-pen2
Allosteric vs. orthosteric**: Can PEN2 be targeted allosterically to achieve selectivity?
Importance Elo
1500
Field Rank
Rank #422 in proteins
Tractability
0.50
Potential Impact
0.50
Evidence Summary
Extracted from wiki page proteins-pen2
Secondary Market
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Evidence Bearing On This Question
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Pairwise Tournament History
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Derived Hypotheses And Proposals
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Related Entities
▸Metadata
| status | open |
| _origin | {'url': None, 'type': 'internal', 'tracked_at': '2026-04-26T03:29:19.713842'} |
| field_tag | proteins |
| source_id | proteins-pen2 |
| sub_field | pen2 |
| source_kind | wiki |
| question_hash | de0cce602b09ed4da623e1e788ac010c4916dbe915b12d4026edd796d45b875a |
| question_text | Allosteric vs. orthosteric**: Can PEN2 be targeted allosterically to achieve selectivity? |
| importance_elo | 1500 |
| _schema_version | 1 |
| evidence_summary | Extracted from wiki page proteins-pen2 |
| evidence_xref_at | 2026-04-27T14:38:59.343717+00:00 |
| tractability_score | 0.5 |
| potential_impact_score | 0.5 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
1
0 supporting
0 contradicting
0 neutral
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