concept

PROTEINS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PROTEINS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1214Connections

6Hypotheses

0Analyses

50Outgoing

50Incoming

10Experiments

0Debates

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💡 Concept Info

Name	PROTEINS
Related Diseases	APOPTOSIS, LATE

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Proteins

index · 465 words

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Pathway Diagram

graph TD
    PROTEINS["PROTEINS"]
    style PROTEINS fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    PROTEINS -->|"involved_in"| Age_Related_Disease_Risk(Age-Related Disease Risk)
    PROTEINS -->|"regulates"| APOPTOSIS(APOPTOSIS)
    PROTEINS -->|"references"| SIRT6([SIRT6])
    PROTEINS -->|"references"| MMP2([MMP2])
    PROTEINS -->|"references"| PYCARD([PYCARD])
    PROTEINS -->|"references"| HNRNPA2B1([HNRNPA2B1])
    PROTEINS -->|"references"| AQP4([AQP4])
    PROTEINS -->|"references"| COX4I1([COX4I1])
    PROTEINS -->|"references"| HSPA1A([HSPA1A])
    PROTEINS -->|"references"| CREB1([CREB1])
    ROS(ROS) -->|"causes"| PROTEINS

Outgoing (113)

Target	Relation	Type	Str
Age-Related Disease Risk	involved_in	phenotype	0.90
Mortality Risk	risk_factor_for	phenotype	0.85
Disease Risk	risk_factor_for	phenotype	0.85
Prostate Cancer Biomarkers	associated_with	biomarker	0.80
APOPTOSIS	regulates	phenotype	0.64
METFORMIN	inhibits	concept	0.50
GLIOSIS	activates	concept	0.50
STRESS GRANULES	interacts_with	concept	0.50
RAPAMYCIN	expressed_in	concept	0.50
ENDOTHELIAL CELLS	interacts_with	concept	0.50
STEM CELLS	interacts_with	concept	0.50
DOPAMINERGIC NEURONS	associated_with	concept	0.50
ENDOPLASMIC RETICULUM	inhibits	concept	0.50
INTERNEURONS	inhibits	concept	0.50
SRPK1	activates	concept	0.50
SRPK1	inhibits	concept	0.50
NEUROFIBRILLARY TANGLES	associated_with	concept	0.50
AUTOPHAGOSOME	inhibits	concept	0.50
NUCLEUS	inhibits	concept	0.50
CELL MIGRATION	associated_with	concept	0.50
ISCHEMIC STROKE	interacts_with	concept	0.50
FRONTAL	associated_with	concept	0.50
TEMPORAL LOBE	associated_with	concept	0.50
CELL PROLIFERATION	associated_with	concept	0.50
CEREBROSPINAL FLUID	expressed_in	concept	0.50
LEWY BODY	activates	concept	0.50
EXTRACELLULAR VESICLES	regulates	concept	0.50
NUCLEUS	regulates	concept	0.50
CENTRAL NERVOUS SYSTEM	inhibits	concept	0.50
ENDOPLASMIC RETICULUM STRESS	inhibits	concept	0.50
SRPK1	interacts_with	concept	0.50
CEREBROSPINAL FLUID	interacts_with	concept	0.50
STRESS GRANULES	activates	concept	0.50
RAPAMYCIN	activates	concept	0.50
CHAPERONE-MEDIATED AUTOPHAGY	activates	concept	0.50
AUTOPHAGOSOME	regulates	concept	0.50
CENTRAL NERVOUS SYSTEM	associated_with	concept	0.50
AUTOPHAGOSOME	activates	concept	0.50
FIBROBLASTS	activates	concept	0.50
ENDOPLASMIC RETICULUM	regulates	concept	0.50
SELECTIVE AUTOPHAGY	regulates	concept	0.50
GENE EXPRESSION	expressed_in	concept	0.50
ENDOPLASMIC RETICULUM	interacts_with	concept	0.50
MTOR SIGNALING	activates	concept	0.50
TEMPORAL LOBE	regulates	concept	0.50
FRONTAL	activates	concept	0.50
CHOLESTEROL METABOLISM	activates	concept	0.50
PEROXISOME	causes	concept	0.50
CEREBROSPINAL FLUID	activates	concept	0.50
PD-L1	inhibits	concept	0.50

Incoming (1101)

Source	Relation	Type	Str
ROS	causes	phenotype	0.64
LIS1	interacts_with	protein	0.50
DIABETES	interacts_with	disease	0.50
Glioma	associated_with	disease	0.50
TERT	inhibits	gene	0.50
IDH1	inhibits	gene	0.50
disease	interacts_with	disease	0.50
VEGFA	inhibits	protein	0.50
MDM4	inhibits	gene	0.50
Immune Checkpoint	inhibits	pathway	0.50
COMPLEMENT	interacts_with	pathway	0.50
TUMOR	inhibits	disease	0.50
HSPG2	inhibits	concept	0.50
ALZHEIMER	interacts_with	gene	0.50
MCL1	inhibits	gene	0.50
ALZHEIMER'S	interacts_with	concept	0.50
APOE	interacts_with	gene	0.50
NTN1	interacts_with	gene	0.50
GPNMB	interacts_with	protein	0.50
NPTX2	interacts_with	protein	0.50
disease	associated_with	disease	0.50
AMYLOID	regulates	gene	0.50
Endocytosis	regulates	pathway	0.50
Exocytosis	regulates	pathway	0.50
TARDBP	interacts_with	gene	0.50
SNRNP70	interacts_with	gene	0.50
NTN3	interacts_with	gene	0.50
AMYLOID	interacts_with	gene	0.50
DIABETES	associated_with	disease	0.50
Type 2 Diabetes	associated_with	disease	0.50
IDH1	associated_with	gene	0.50
Type 2 Diabetes	interacts_with	disease	0.50
DIABETES	activates	disease	0.50
HEAT SHOCK PROTEINS	associated_with	protein	0.50
MITOCHONDRIA	activates	cell_type	0.50
PARKIN	activates	gene	0.50
PARK2	activates	gene	0.50
PINK1	activates	gene	0.50
BNIP3	activates	gene	0.50
GABARAPL2	activates	gene	0.50
GABARAP	activates	protein	0.50
mitophagy	activates	pathway	0.50
MITOCHONDRIA	associated_with	cell_type	0.50
MITOCHONDRIAL DNA	associated_with	gene	0.50
MTDNA	associated_with	gene	0.50
KIF5A	interacts_with	gene	0.50
TRAK1	interacts_with	concept	0.50
AXON	associated_with	concept	0.50
TRAK1	associated_with	concept	0.50
DYNEIN	interacts_with	protein	0.50

Targeting Hypotheses (6)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
C9orf72 Hexanucleotide Repeat Dipeptide Repeat Proteins Inhi	0.738	neurodegeneration	Legacy Pre-Pipeline Hypothesis Import
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m	0.621	neurodegeneration	Mitochondrial transfer between astrocyte
RNA-binding proteins stabilize or gate the lncRNA-0021:mmu-m	0.497	molecular neurobiology	How does lncRNA-0021 achieve sequence-sp
Sulfated glycans and metal-binding CSF proteins brace alpha-	0.489	neurodegeneration	Which specific CSF molecular components
CHIP E3 Ligase Enhancement to Target Synaptic Proteins for D	0.474	proteomics	Quantitative proteomics of the aging syn

Alectinib Binds Mitochondrial C1q-like Proteins (C1QDC1) Rat	0.122	molecular biology	Does Alectinib truly bind C1q directly w

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (10)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
s:** - Test MCU overexpression specifically in layer II neurons in hea	falsification	Neurodegeneration	0.400	0.50	mouse	proposed	$200,000
Proposed experiment from debate on Mitochondrial transfer between astr	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$80,000
Proposed experiment from debate on Mitochondrial transfer between astr	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$100,000
AAV-LRRK2 IND-Enabling Study Design	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$7,500,000
Axonal Transport Dysfunction Validation in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
Gap Junction Dysfunction Validation in Parkinson's Disease	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
AAV-LRRK2 Gene Therapy IND-Enabling Study Design	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
Experiment Design: Metal Ion-Synuclein-Mitochondria Axis in Parkinson'	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
Selective Neuronal Vulnerability to Aging — Mapping Why Specific Neuro	validation	Neurodegeneration	0.400	0.50	human	proposed	$3,000,000
Synaptic Mitochondrial Resilience Enhancement for Parkinson's Disease	validation	Parkinson's Disease	0.400	0.50	human	proposed	$2,730,000

Related Papers (15)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
KIF5A de novo mutation associated with myoclonic seizures and neonatal onset pro [PMID:27414745]	Rydzanicz M, Jagła M, Kosinska J, Tomasi	Clin Genet	2017	1
TRAK/Milton motor-adaptor proteins steer mitochondrial trafficking to axons and [PMID:23395375]	van Spronsen M, Mikhaylova M, Lipka J, S	Neuron	2013	1
Delineation of the TRAK binding regions of the kinesin-1 motor proteins. [PMID:24161670]	Randall TS, Moores C, Stephenson FA	FEBS Lett	2013	1
Therapeutic developments in pancreatic cancer. [PMID:37798442]	["Hu Z", "O'Reilly E"]	Nature reviews. Gastroenterolo	2024	0
Defining treatment-resistant depression. [PMID:31638723]	["Gaynes B", "Lux L", "Gartlehner G", "A	Depression and anxiety	2020	0
Emerging trends in global freshwater availability. [PMID:29769728]	["Rodell M", "Famiglietti J", "Wiese D",	Nature	2018	0
Acute Heart Failure: Definition, Classification and Epidemiology. [PMID:28785969]	["Kurmani S", "Squire I"]	Current heart failure reports	2017	0
Invasive ductal carcinoma: relationship between pathological characteristics and [PMID:28658335]	["Aquino R", "Vasques P", "Cavalcante D"	Revista do Colegio Brasileiro	2017	0
The Impact of Intergenerational Cultural Dissonance on Alcohol Use Among Vietnam [PMID:26598062]	["Kane J", "Johnson R", "Robinson C", "J	The Journal of adolescent heal	2016	0
A proliferative burst during preadolescence establishes the final cardiomyocyte [PMID:24813607]	["Naqvi N", "Li M", "Calvert J", "Tejada	Cell	2014	0
Family medicine match rate increases slightly. [PMID:22585896]	Sheri Porter	Annals of family medicine	2012	0
Human plasma glycome in attention-deficit hyperactivity disorder and autism spec [PMID:20974899]	["Pivac N", "Knezevi\u0107 A", "Gornik O	Molecular & cellular proteomic	2011	0
The Crumbs complex: from epithelial-cell polarity to retinal degeneration. [PMID:19625503]	["Bulgakova N", "Knust E"]	Journal of cell science	2009	0
CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell [PMID:18971423]	["Landsman L", "Bar-On L", "Zernecke A",	Blood	2009	0
GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins [PMID:15644324]	Brickley K, Smith MJ, Beck M, Stephenson	The Journal of biological chem	2005	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PROTEINS in their description or question text

Alectinib Binds Mitochondrial C1q-like Proteins (C1QDC1) Rather Than Circulating

Score: 0.122 · molecular biology · 2026-04-18

## Mechanistic Overview Alectinib Binds Mitochondrial C1q-like Proteins (C1QDC1) Rather Than Circulating C1q starts from