AMPK hypersensitivity in astrocytes creates enhanced mitochondrial rescue responses

**AMPK Hypersensitivity Engineering for Neuroprotection: Astrocyte-Mediated Mitochondrial Rescue** **Overview and Conceptual Framework** Neurons are exquisitely vulnerable to mitochondrial dysfunction due to their high metabolic demands and limited regenerative capacity. In Alzheimer's disease and other neurodegenerative conditions, mitochondrial impairment (reduced ATP production, increased ROS, impaired Ca2+ buffering) precedes overt cell death by months to years. During this "metabolic prod...