Synaptic Vesicle Tau Capture Inhibition

**Molecular Mechanism and Rationale** The synaptic vesicle tau capture inhibition hypothesis centers on the critical role of SNAP25 (Synaptosome-Associated Protein of 25 kDa) in facilitating pathological tau protein uptake at presynaptic terminals during synaptic vesicle recycling processes. SNAP25 is a key component of the SNARE (Soluble N-ethylmaleimide-sensitive factor Attachment protein REceptor) complex, which mediates synaptic vesicle fusion with the presynaptic membrane during neurotrans...