protein 1,497 words KG: PEN2
Contents

PEN2 Protein

🔬 Protein Info
Gene SymbolPSENEN
AliasesPresenilin Enhancer 2
Chromosome19q13.12
Protein FamilyPEN-2 family (γ-secretase complex)
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary ExpressionEndoplasmic reticulum, Golgi apparatus, plasma membrane
Molecular Weight12 kDa
Amino Acids101 aa
PathwaysAngiogenesis
UniProt IDQ9NQ75
GeneCardsPSENEN
Human Protein AtlasPSENEN
Associated DiseasesAD, Als, Alzheimer, Alzheimer's disease, AMI
InteractionsA2M, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, APH1B
KG Connections98 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (11)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74

Related Analyses (9)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Key Papers (6)

Assessment of the Spatial Distribution of Moisture Content in Granular
Sensors (Basel, Switzerland) 2024
Multiple Primary Malignancies in Head and Neck Cancer: A University Ho
Cureus 2021
Controlled synthesis of silver-based ternary quantum dots with outstan
Journal of fluorescence 2022
A vision-based real-time traffic flow monitoring system for road inter
Multimedia tools and applicati 2023
Impact of Specialized Treatment Setting on Survival in Adolescent and
JCO oncology practice 2023

See Also (13)

Apoptosis in Neurodegeneration
entity · KG edge: interacts_with
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: interacts_with
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: interacts_with
A2M Gene
gene · KG edge: interacts_with
ANG — Angiogenin
gene · KG edge: associated_with

Knowledge Graph (12 edges)

NCSTN interacts_with PEN2
FAS interacts_with PEN2
TNF interacts_with PEN2
LMNA interacts_with PEN2
APH1B interacts_with PEN2
APOE interacts_with PEN2
IL6 interacts_with PEN2
SREBF1 interacts_with PEN2
PSEN2 interacts_with PEN2
A2M interacts_with PEN2

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