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What is the complete inventory of BACE1 substrates, and how does chronic inhibition affect their function?
active
open question
Created: 2026-04-25T20:29:45
By: backfill_open_questions
Quality:
50%
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ID: open_question-76b9e7e9-562d-4641-8a54-50
Open Question
open
Wiki: mechanisms-app-bace1-fe65-complex
What is the complete inventory of BACE1 substrates, and how does chronic inhibition affect their function?
Importance Elo
1500
Field Rank
Rank #1196 in mechanisms
Tractability
0.50
Potential Impact
0.50
Evidence Summary
Extracted from wiki page mechanisms-app-bace1-fe65-complex
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Evidence Bearing On This Question
Subcellular protein interaction role identification
partial answer for · experiment · 72%
Palmitoylation-Targeted BACE1 Trafficking Disruptors
bears on question · hypothesis · 65%
Glycine-Rich Domain Competitive Inhibition
bears on question · hypothesis · 58%
Pairwise Tournament History
No pairwise judgments recorded yet.
Derived Hypotheses And Proposals
Palmitoylation-Targeted BACE1 Trafficking Disruptors
hypothesis | bears_on_question
Glycine-Rich Domain Competitive Inhibition
hypothesis | bears_on_question
Related Entities
▸Metadata
| status | open |
| _origin | {'url': None, 'type': 'internal', 'tracked_at': '2026-04-26T03:29:45.997405'} |
| field_tag | mechanisms |
| source_id | mechanisms-app-bace1-fe65-complex |
| sub_field | app-bace1-fe65-complex |
| source_kind | wiki |
| question_hash | b47b46f2dcbee8106601b685ed5688be2ca781de6ae6ee4d0dd6810b0f2a39bb |
| question_text | What is the complete inventory of BACE1 substrates, and how does chronic inhibition affect their function? |
| importance_elo | 1500 |
| _schema_version | 1 |
| evidence_summary | Extracted from wiki page mechanisms-app-bace1-fe65-complex |
| evidence_xref_at | 2026-04-27T12:01:56.959398+00:00 |
| tractability_score | 0.5 |
| potential_impact_score | 0.5 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
4
0 supporting
0 contradicting
0 neutral
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