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What is the relationship between SORCS2 and other AD risk genes?
active
open question
Created: 2026-04-25T20:29:48
By: backfill_open_questions
Quality:
50%
✓ SciDEX
ID: open_question-783c0ff6-2f94-48e6-8df1-21
Open Question
open
Wiki: genes-sorcs2
What is the relationship between SORCS2 and other AD risk genes?
Importance Elo
1500
Field Rank
Rank #1500 in genes
Tractability
0.50
Potential Impact
0.50
Evidence Summary
Extracted from wiki page genes-sorcs2
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Evidence Bearing On This Question
TREM2 Function in Alzheimer's Disease — From Risk Variant to Therapeutic Target
partial answer for · experiment · 60%
APOE Isoform Expression Across Glial Subtypes
partial answer for · hypothesis · 55%
TREM2-Mediated Astrocyte-Microglia Crosstalk in Neurodegeneration
partial answer for · hypothesis · 50%
CD2AP expression and cognitive decline in AD patients
partial answer for · experiment · 45%
CD2AP loss association with cognitive decline in AD patients
partial answer for · experiment · 45%
Pairwise Tournament History
No pairwise judgments recorded yet.
Derived Hypotheses And Proposals
TREM2-Mediated Astrocyte-Microglia Crosstalk in Neurodegeneration
hypothesis | partial_answer_for
APOE Isoform Expression Across Glial Subtypes
hypothesis | partial_answer_for
Related Entities
▸Metadata
| status | open |
| _origin | {'url': None, 'type': 'internal', 'tracked_at': '2026-04-26T03:29:48.686680'} |
| field_tag | genes |
| source_id | genes-sorcs2 |
| sub_field | sorcs2 |
| source_kind | wiki |
| question_hash | e4ca77fc1cde6cf9fc4e8bbf43f124ef03dd26a5f8154ffd0cd5875680adc28d |
| question_text | What is the relationship between SORCS2 and other AD risk genes? |
| importance_elo | 1500 |
| _schema_version | 1 |
| evidence_summary | Extracted from wiki page genes-sorcs2 |
| evidence_xref_at | 2026-04-27T11:33:15.350942+00:00 |
| tractability_score | 0.5 |
| potential_impact_score | 0.5 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
6
0 supporting
0 contradicting
0 neutral
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