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CD2AP loss association with cognitive decline in AD patients

experiment Created: 2026-04-06 12:34:46 By: experiment_extractor Quality: 85% ✓ SciDEX ID: experiment-exp-f22372cb-4726-4e8a-9357-5
🧫 Experiment Protocol Genetic Association
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Related Entities
CD2AP
Metadata
experiment_typegenetic_association
protocolpost-mortem brain tissue analysis with correlation to cognitive assessments
expected_outcomesreduced CD2AP in cerebral vessels correlates with cognitive decline
success_criteriasignificant correlation between CD2AP loss and cognitive impairment
sample_sizeNone
statistical_methodsNone
p_valueNone
effect_sizeNone
extracted_at2026-04-06T05:34:46.497706
source_pmid39892386
_origin{'type': 'internal', 'url': None, 'tracked_at': '2026-04-06T12:34:46.500034'}
🌍 Provenance Graph 2 nodes, 1 edges

derives from (1)

Linked Artifacts (47)
derives_from📄Loss of endothelial CD2AP causes sex-dependent cerebrovascul100%
related🧫Endothelial CD2AP knockdown effects on memory in male mice100%
related🧫CD2AP expression and cognitive decline in AD patients100%
related🧫Endothelin-1 receptor A antagonist rescue in male CD2AP mice100%
related🧫Endothelin-1 receptor A antagonist rescue experiment100%
related🧫Reelin treatment rescue via ApoER2 in CD2AP mutant mice100%
related🧫CD2AP downregulation in brain endothelial cells - memory fun100%
related🧫Cerebral blood flow regulation in CD2AP mutant mice100%
related🧫Reelin glycoprotein treatment rescue experiment100%
related🧫Cerebrovascular function analysis in CD2AP mutant mice100%
mentions📖CD2AP Gene — CD2-Associated Protein70%
mentions📖CD2AP Synaptic Dysfunction Alzheimer's Disease Causal C70%
mentions📖CD2AP Protein70%
related📖CD2AP Gene — CD2-Associated Protein63%
related📖CD2AP Synaptic Dysfunction Alzheimer's Disease Causal C63%
related📖CD2AP Protein63%
mentions📖Agitation in Alzheimer's Disease60%
mentions📖Alzheimer's Disease60%
mentions📖Alzheimer's Disease Genetic Variants60%
mentions📖Alzheimer's Disease vs Parkinson's Disease Compari60%
mentions📖APP Mutations in Alzheimer's Disease60%
mentions📖DLB, Parkinson's Disease, and Alzheimer's Disease:60%
mentions📖Early-Onset Alzheimer's Disease (EOAD)60%
mentions📖Investment Landscape: Alzheimer's Disease60%
mentions📖Preclinical Alzheimer's Disease60%
mentions📖Prodromal Alzheimer's Disease60%
mentions📖PSEN1 Mutations in Alzheimer's Disease60%
mentions📖PSEN2 Mutations in Alzheimer's Disease60%
mentions📖Sporadic vs Familial Alzheimer's Disease: Comprehensive60%
mentions📖TREM2 Variants in Alzheimer's Disease60%
related🧫Endothelin-1 receptor A antagonist rescue in male CD2AP mice60%
related🧫Endothelin-1 receptor A antagonist rescue experiment60%
related📖Alzheimer's Disease60%
related📖Agitation in Alzheimer's Disease54%
related📖Alzheimer's Disease54%
related📖Alzheimer's Disease Genetic Variants54%
related📖Alzheimer's Disease vs Parkinson's Disease Compari54%
related📖APP Mutations in Alzheimer's Disease54%
related📖DLB, Parkinson's Disease, and Alzheimer's Disease:54%
related📖Early-Onset Alzheimer's Disease (EOAD)54%
related📖Investment Landscape: Alzheimer's Disease54%
related📖Preclinical Alzheimer's Disease54%
related📖Prodromal Alzheimer's Disease54%
related📖PSEN1 Mutations in Alzheimer's Disease54%
related📖PSEN2 Mutations in Alzheimer's Disease54%
related📖Sporadic vs Familial Alzheimer's Disease: Comprehensive54%
related📖TREM2 Variants in Alzheimer's Disease54%

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