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Efflux of monoclonal antibodies from rat brain by neonatal Fc receptor, FcRn.
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ID: paper-23978455
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Efflux of monoclonal antibodies from rat brain by neonatal Fc receptor, FcRn.
["Cooper P", "Ciambrone G", "Kliwinski C", "Maze E", "Johnson L", "Li Q", "Feng Y", "Hornby P"]
Abstract
Monoclonal antibody (mAb) engineering that optimizes binding to receptors present on brain vascular endothelial cells has enabled them to cross through the blood-brain barrier (BBB) and access the brain parenchyma to treat neurological diseases. However, once in the brain the extent to which receptor-mediated reverse transcytosis clears mAb from the brain is unknown. The aim of this study was to determine the contribution of the neonatal Fc-receptor (FcRn) in rat brain efflux employing two diffe...
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