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Activation of Piezo1 contributes to matrix stiffness-induced angiogenesis in hepatocellular carcinoma.
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ID: paper-36181398
📄 Paper Details
Activation of Piezo1 contributes to matrix stiffness-induced angiogenesis in hepatocellular carcinoma.
Li M, Zhang X, Wang M, Wang Y, Qian J, Xing X, Wang Z, You Y, Guo K, Chen J, Gao D, Zhao Y, Zhang L, Chen R, Cui J, Ren Z
Abstract
BACKGROUND: Despite integrin being highlighted as a stiffness-sensor molecule in matrix stiffness-driven angiogenesis, other stiffness-sensor molecules and their mechanosensory pathways related to angiogenesis in hepatocellular carcinoma (HCC) remain obscure. Here, we explored the interplay between Piezo1 and integrin β1 in the mechanosensory pathway and their effects on HCC angiogenesis to better understand matrix stiffness-induced angiogenesis. METHODS: The role of Piezo1 in matrix stiffness-i...
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