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Antibody Engineering for Receptor-Mediated Transcytosis Across the Blood-Brain Barrier.
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ID: paper-41031862
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Antibody Engineering for Receptor-Mediated Transcytosis Across the Blood-Brain Barrier.
["Guo K", "Cao D", "Marchese-Thomas L", "Dong Y"]
Abstract
Efficient delivery of therapeutic antibodies into the central nervous system (CNS) remains severely limited by the restrictive nature of the blood-brain barrier (BBB). Receptor-mediated transcytosis (RMT) has emerged as a promising strategy to enhance antibody transport across the BBB. In this Viewpoint, we highlight recent advances in RMT-based antibody delivery, focusing specifically on three representative BBB receptors: transferrin receptor (TfR), insulin receptor (InsR), and neonatal Fc rec...
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