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Fig. 2: SPP1 is expressed by PVMs and fibroblasts. a – c , Representative images of Spp...
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Created: 2026-04-15T23:28:06
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Fig. 2Figure 2
SPP1 is expressed by PVMs and fibroblasts. a – c , Representative images of Spp1 mRNA expression juxtaposed to GLUT1 + vasculature, colocalizing with pan-PVM markers Cd163 ( a ), CD206 ( b ) and PVF ( Pdgfra + ) ( c ) in 6-month App NL-F SLM as characterized by smFISH-IHC. Scale bar represents 10 µm. Data are representative of four App NL-F mice examined over two independent experiments. d – f , Representative FACS plots to identify PVMs (CX3CR1 + CD45 + CD11b + CD206 + ( d ), microglia CX3CR1 high CD45 + CD11b + ( e ) or gated on total TdT expressing cells isolated from Spp1 TdT hippocampal homogenates and quantification ( f )). One datapoint represents one cell type per mouse (PVM, PVF and microglia) pooled from n = 7 mice examined over two independent experiments ( f ). P values from one-way ANOVA, Bonferroni’s multiple comparison test. g , Three-dimensional reconstruction of CD206 + PVMs expressing SPP1-Td along GLUT1 + vessels in SLM from Spp1 TdT mice. Scal
▸Metadata
| doi | |
| pmcid | PMC9991912 |
| _origin | {'url': 'https://www.ebi.ac.uk/europepmc/articles/PMC9991912/bin/41593_2023_1257_Fig2_HTML.jpg', 'type': 'external', 'tracked_at': '2026-04-15T23:28:06.212381'} |
| caption | SPP1 is expressed by PVMs and fibroblasts. a – c , Representative images of Spp1 mRNA expression juxtaposed to GLUT1 + vasculature, colocalizing with pan-PVM markers Cd163 ( a ), CD206 ( b ) and |
| paper_id | 36747024 |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC9991912/bin/41593_2023_1257_Fig2_HTML.jpg |
| image_path | |
| description | |
| figure_label | Fig. 2 |
| figure_number | 2 |
| _schema_version | 1 |
| source_strategy | pmc_api |
| entities_mentioned |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
1
0 supporting
0 contradicting
0 neutral
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