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Fig. 4: SPP1 drives microglial engulfment of synapses in AD context. a – d , Representat...
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Created: 2026-04-15T23:28:06
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Fig. 4Figure 4
SPP1 drives microglial engulfment of synapses in AD context. a – d , Representative image of 3D reconstructed P2Y12 + microglia expressing phagocytic markers Ctsb ( a , b ) and Grn ( c , d ) assessed by smFISH-IHC in 6-month WT, Spp1 KO/KO , App NL-F and App NL-F · Spp1 KO/KO SLM. Scale bar represents 7 µm. Quantification of Ctsb ( b ) and Grn ( d ) mRNA levels expression within P2Y12 + microglia. One datapoint represents average of 1 mouse, calculated from 6 individual P2Y12 + microglia per mouse ( b ) and 3–6 microglia ( d ) from n = 3 mice per genotype examined over 2 independent experiments. P Values from two-way ANOVA, Bonferroni’s multiple comparison test for ( b ). e , Representative 3D reconstructed images showing Homer1 engulfment within CD68 + lysosomes of P2Y12 + microglia in 6-month App NL-F versus App NL-F · Spp1 KO/KO SLM. Scale bar represents 7 µm. f , Quantification of Homer1 engulfment ratio in P2Y12 + microglia of WT versus Spp1 KO/KO ver
▸Metadata
| doi | |
| pmcid | PMC9991912 |
| _origin | {'url': 'https://www.ebi.ac.uk/europepmc/articles/PMC9991912/bin/41593_2023_1257_Fig4_HTML.jpg', 'type': 'external', 'tracked_at': '2026-04-15T23:28:06.243481'} |
| caption | SPP1 drives microglial engulfment of synapses in AD context. a – d , Representative image of 3D reconstructed P2Y12 + microglia expressing phagocytic markers Ctsb ( a , b ) and Grn ( c , d ) asse |
| paper_id | 36747024 |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC9991912/bin/41593_2023_1257_Fig4_HTML.jpg |
| image_path | |
| description | |
| figure_label | Fig. 4 |
| figure_number | 4 |
| _schema_version | 1 |
| source_strategy | pmc_api |
| entities_mentioned |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
1
0 supporting
0 contradicting
0 neutral
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