Nucleus of the Solitary Tract (NTS) Neurons
<table class="infobox infobox-celltype">
<tr>
<th class="infobox-header" colspan="2">Nucleus of the Solitary Tract (NTS) Neurons</th>
</tr>
<tr>
<td class="label">Allen Atlas ID</td>
<td><a href="https://portal.brain-map.org/atlases-and-data/rnaseq" target="_blank">CS202210140_3610</a></td>
</tr>
<tr>
<td class="label">Lineage</td>
<td>Neuron > Visceral sensory > Nucleus tractus solitarii</td>
</tr>
<tr>
<td class="label">Markers</td>
<td>PHOX2B, TNNT3, SLC17A6, NTS, GLP1R</td>
</tr>
<tr>
<td class="label">Brain Regions</td>
<td>Dorsal medulla, Nucleus of the solitary tract</td>
</tr>
<tr>
<td class="label">Disease Vulnerability</td>
<td>[Multiple System Atrophy](/diseases/multiple-system-atrophy), [Parkinson's Disease](/diseases/parkinsons-disease)</td>
</tr>
</table>
Nucleus of the Solitary Tract (NTS) Neurons
Introduction
Nucleus Of The Solitary Tract (Nts) [Neurons](/entities/neurons) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Overview
...Nucleus of the Solitary Tract (NTS) Neurons
<table class="infobox infobox-celltype">
<tr>
<th class="infobox-header" colspan="2">Nucleus of the Solitary Tract (NTS) Neurons</th>
</tr>
<tr>
<td class="label">Allen Atlas ID</td>
<td><a href="https://portal.brain-map.org/atlases-and-data/rnaseq" target="_blank">CS202210140_3610</a></td>
</tr>
<tr>
<td class="label">Lineage</td>
<td>Neuron > Visceral sensory > Nucleus tractus solitarii</td>
</tr>
<tr>
<td class="label">Markers</td>
<td>PHOX2B, TNNT3, SLC17A6, NTS, GLP1R</td>
</tr>
<tr>
<td class="label">Brain Regions</td>
<td>Dorsal medulla, Nucleus of the solitary tract</td>
</tr>
<tr>
<td class="label">Disease Vulnerability</td>
<td>[Multiple System Atrophy](/diseases/multiple-system-atrophy), [Parkinson's Disease](/diseases/parkinsons-disease)</td>
</tr>
</table>
Nucleus of the Solitary Tract (NTS) Neurons
Introduction
Nucleus Of The Solitary Tract (Nts) [Neurons](/entities/neurons) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Overview
Nucleus of the Solitary Tract (NTS) Neurons are a specialized cell type classified within the Neuron > Visceral sensory > Nucleus tractus solitarii lineage. These cells are primarily found in Dorsal medulla, Nucleus of the solitary tract and are characterized by expression of marker genes including PHOX2B, TNNT3, SLC17A6, NTS. They are selectively vulnerable in [Multiple System Atrophy](/diseases/multiple-system-atrophy), [Parkinson's Disease](/diseases/parkinsons-disease).
<!-- multi-taxonomy-enrichment -->
Multi-Taxonomy Classification
Taxonomy Database Cross-References
| Taxonomy | ID | Name / Label |
|----------|----|---------------|
| Cell Ontology (CL) | [CL:0002614](https://www.ebi.ac.uk/ols4/ontologies/cl/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCL_0002614) | neuron of the substantia nigra |
Morphology & Electrophysiology
- Morphology: neuron of the substantia nigra (source: Cell Ontology)
- Morphology can be inferred from Cell Ontology classification
External Database Links
- [Cell Ontology (CL:0002614)](https://www.ebi.ac.uk/ols4/ontologies/cl/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCL_0002614)
- [OBO Foundry (CL:0002614)](http://purl.obolibrary.org/obo/CL_0002614)
- [Allen Brain Cell Atlas](https://portal.brain-map.org/atlases-and-data/bkp/abc-atlas)
- [CellxGene Census](https://cellxgene.cziscience.com/)
- [Human Cell Atlas](https://www.humancellatlas.org/)
Morphology and Markers
Nucleus of the Solitary Tract (NTS) Neurons are identified by the expression of the following key marker genes:
- PHOX2B
- TNNT3
- SLC17A6
- NTS
- GLP1R
These markers are used for immunohistochemical identification and single-cell RNA sequencing classification, as catalogued in the [Allen Cell Type Atlas](https://portal.brain-map.org/atlases-and-data/rnaseq).
Normal Function
Nucleus of the Solitary Tract (NTS) Neurons play essential roles in neural circuits and brain function. They are found in the following brain regions:
- Dorsal medulla
- Nucleus of the solitary tract
Their normal functions include maintaining neural circuit integrity, signal processing, and contributing to the homeostasis of their local microenvironment.
Vulnerability in Disease
Nucleus of the Solitary Tract (NTS) Neurons show selective vulnerability in the following neurodegenerative conditions:
- [Multiple System Atrophy](/diseases/multiple-system-atrophy)
- [Parkinson's Disease](/diseases/parkinsons-disease)
The selective vulnerability of these cells is an active area of research, with factors including metabolic demands, calcium handling, exposure to toxic protein aggregates, and cell-autonomous gene expression programs contributing to their susceptibility.
Transcriptomic Profile
Single-cell and single-nucleus RNA sequencing studies have revealed the transcriptomic signature of Nucleus of the Solitary Tract (NTS) Neurons. Key differentially expressed genes from the Allen Cell Type Atlas and related datasets include the marker genes listed above. These transcriptomic profiles help identify subtypes and disease-associated gene expression changes.
Key Publications
[Nucleus of the solitary tract in autonomic control](https://doi.org/10.1038/s41583-020-0350-9). Nat Rev Neurosci, 2020.
External Links
- Allen Cell Type Atlas: [https://portal.brain-map.org/atlases-and-data/rnaseq](https://portal.brain-map.org/atlases-and-data/rnaseq)
- Allen Human Brain Atlas: [https://human.brain-map.org/](https://human.brain-map.org/)
- [Cell Types Index](/cell-types)
- [Genes Index](/genes)
- [Diseases Index](/diseases)
- [Mechanisms Index](/mechanisms)
- [--](/proteins/n--cadherin-protein)
Background
The study of Nucleus Of The Solitary Tract (Nts) Neurons has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.