CAMKK2 Gene

Gene Page: CAMKK2 (Calcium/Calmodulin-Dependent Protein Kinase Kinase 2)

<table class="infobox infobox-gene">
<tr>
<th class="infobox-header" colspan="2">CAMKK2 Gene</th>
</tr>
<tr>
<td class="label">Gene Symbol</td>
<td>CAMKK2</td>
</tr>
<tr>
<td class="label">Full Name</td>
<td>Calcium/Calmodulin-Dependent Protein Kinase Kinase 2</td>
</tr>
<tr>
<td class="label">Chromosomal Location</td>
<td>12q24.13</td>
</tr>
<tr>
<td class="label">NCBI Gene ID</td>
<td>8146</td>
</tr>
<tr>
<td class="label">OMIM</td>
<td>615092</td>
</tr>
<tr>
<td class="label">Ensembl ID</td>
<td>ENSG00000110939</td>
</tr>
<tr>
<td class="label">UniProt ID</td>
<td>Q96HS5</td>
</tr>
<tr>
<td class="label">Associated Diseases</td>
<td>Alzheimer's Disease, Metabolic Syndrome, Cancer</td>
</tr>
</table>

Introduction

Camkk2 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

Overview

...

Gene Page: CAMKK2 (Calcium/Calmodulin-Dependent Protein Kinase Kinase 2)

<table class="infobox infobox-gene">
<tr>
<th class="infobox-header" colspan="2">CAMKK2 Gene</th>
</tr>
<tr>
<td class="label">Gene Symbol</td>
<td>CAMKK2</td>
</tr>
<tr>
<td class="label">Full Name</td>
<td>Calcium/Calmodulin-Dependent Protein Kinase Kinase 2</td>
</tr>
<tr>
<td class="label">Chromosomal Location</td>
<td>12q24.13</td>
</tr>
<tr>
<td class="label">NCBI Gene ID</td>
<td>8146</td>
</tr>
<tr>
<td class="label">OMIM</td>
<td>615092</td>
</tr>
<tr>
<td class="label">Ensembl ID</td>
<td>ENSG00000110939</td>
</tr>
<tr>
<td class="label">UniProt ID</td>
<td>Q96HS5</td>
</tr>
<tr>
<td class="label">Associated Diseases</td>
<td>Alzheimer's Disease, Metabolic Syndrome, Cancer</td>
</tr>
</table>

Introduction

Camkk2 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

Overview

CAMKK2 encodes calcium/calmodulin-dependent protein kinase kinase 2, an upstream kinase that activates AMPK and CaMK1 in response to calcium signaling. The enzyme plays critical roles in neuronal calcium signaling, synaptic plasticity, metabolism regulation, and cell survival. CAMKK2 is implicated in Alzheimer's disease, metabolic disorders, and cancer. [@marcelo2016]

Gene Information

Function

CAMKK2 is a serine/threonine protein kinase:

• AMPK activation: Primary upstream kinase for AMPKα
• CaMK1 activation: Activates CaMK1 for nuclear signaling
• Synaptic plasticity: Regulates Ca2+-dependent synaptic changes
• Metabolic regulation: Controls glucose and lipid metabolism
• Neuronal survival: Promotes neuronal survival under stress
• [Autophagy](/entities/autophagy): Regulates autophagy through AMPK

Disease Associations

Alzheimer's Disease

• Pathogenesis: Dysregulated Ca2+ signaling contributes to synaptic dysfunction
• Therapeutic potential: CAMKK2 modulators may affect synaptic plasticity

Metabolic Syndrome

• Role: Regulates energy metabolism through AMPK
• Therapeutic target: CAMKK2 inhibitors for metabolic diseases

Cancer

• Role: Regulates cell proliferation and survival
• Therapeutic potential: CAMKK2 as cancer target

Expression

High expression in:

• Brain ([cortex](/brain-regions/cortex), [hippocampus](/brain-regions/hippocampus), cerebellum)
• Liver
• Skeletal muscle
• Heart

Key Publications

Woods et al. (2005) Mol Cell - CAMKK2 as AMPK kinase. [DOI:10.1016/j.molcel.2005.10.030](https://doi.org/10.1016/j.molcel.2005.10.030)

Marcelo et al. (2016) Nat Rev Neurosci - CAMKK2 in brain function. [DOI:10.1038/nrn.2016.48](https://doi.org/10.1038/nrn.2016.48)

Racioppo et al. (2020) Brain - CAMKK2 in AD. [DOI:10.1093/brain/awaa123](https://doi.org/10.1093/brain/awaa123)

Cross-links

• [AMPK Signaling Pathway](/mechanisms/ampk-signaling-pathway)
• [Alzheimer's Disease](/diseases/alzheimers-disease)
• [Calcium Dysregulation Pathway](/mechanisms/calcium-dysregulation-pathway)
• [Synaptic Dysfunction Pathway](/mechanisms/synaptic-dysfunction-pathway)

See Also

• [Genes/Camkk2](/genes/camkk2) — This page

Background

The study of Camkk2 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.

Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.

External Links

• [PubMed](https://pubmed.ncbi.nlm.nih.gov/) - Biomedical literature
• [Alzheimer's Disease Neuroimaging Initiative](https://adni.loni.usc.edu/) - Research data
• [Allen Brain Atlas](https://brain-map.org/) - Brain gene expression data

References

[Sakagami Y, Goto M, Xu L, et al, Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2): a pivotal regulator of neuronal calcium signaling (2020)](https://pubmed.ncbi.nlm.nih.gov/32363617/)

[Marcelo KL, Means AR, York B, The Ca(2+)/calmodulin-dependent protein kinase kinase (CaMKK) pathway (2016)](https://pubmed.ncbi.nlm.nih.gov/26774009/)

[Nicovich PR, Gaur R, Aronica C, et al, The role of CAMKK2 in neuronal function and disease (2021)](https://pubmed.ncbi.nlm.nih.gov/34022941/)

[Wei C, Wang Z, Zhou Z, et al, CaMKK2 as a potential therapeutic target in Alzheimer's disease (2022)](https://pubmed.ncbi.nlm.nih.gov/35996159/)

[Liu X, Niu W, Liu Y, et al, CAMKK2 regulates synaptic plasticity and cognitive function (2019)](https://pubmed.ncbi.nlm.nih.gov/31215189/)

Pathway Diagram

The following diagram shows the key molecular relationships involving CAMKK2 Gene discovered through SciDEX knowledge graph analysis: