gene

CAMKK2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CAMKK2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

81Connections

0Hypotheses

0Analyses

50Outgoing

21Incoming

0Experiments

Summary

CAMKK2 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, activates, expressed in. Associated with Aging, Als, Autoimmune. Connected to 42 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CAMKK2
Full Name	Calcium/Calmodulin-Dependent Protein Kinase Kinase 2
Chromosome	12q24.13
Protein Type	Kinase
Function	CAMKK2 is a serine/threonine protein kinase
Molecular Weight	65 kDa
Pathways	AMPK, AMPK Signaling, ampk, mTOR
UniProt ID	Q96HS5
NCBI Gene ID	8146
Ensembl ID	ENSG00000110939
OMIM	615092
GeneCards	CAMKK2
Human Protein Atlas	CAMKK2
Associated Diseases	Aging, Alzheimer, Diabetes, Ferroptosis, dementia
Interactions	LC3, COX4I1, GFAP, IBA1, LAMP2, MAP1LC3B
KG Connections	80 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CAMKK2 — AlphaFold Q96HS5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (13)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CAMKK2["<b>CAMKK2</b>"]
    Autoimmune{"Autoimmune"}
    CAMKK2 -->|"expressed in"| Autoimmune
    Multiple_Sclerosis{"Multiple Sclerosis"}
    CAMKK2 -->|"expressed in"| Multiple_Sclerosis
    Ms{"Ms"}
    CAMKK2 -->|"expressed in"| Ms
    Als{"Als"}
    CAMKK2 -->|"expressed in"| Als
    P2RX7["P2RX7"]
    CAMKK2 -->|"expressed in"| P2RX7
    P2RX4["P2RX4"]
    CAMKK2 -->|"expressed in"| P2RX4
    neurodegeneration["neurodegeneration"]
    CAMKK2 -->|"implicated in"| neurodegeneration
    GAIN["GAIN"]
    GAIN -->|"expressed in"| CAMKK2
    style CAMKK2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (60)

Target	Relation	Type	Str
Metastasis	activates	pathway	0.70
Autoimmune	expressed_in	disease	0.65
Multiple Sclerosis	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Tumor	activates	disease	0.65
Cancer	activates	disease	0.65
Als	activates	disease	0.65
Lung Cancer	activates	disease	0.65
Tumor	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Aging	inhibits	disease	0.65
Lung Cancer	inhibits	disease	0.65
Pancreatic Cancer	inhibits	disease	0.65
Cancer	therapeutic_target	disease	0.65
Liver Cancer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Carcinoma	inhibits	disease	0.65
Ferroptosis	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
P2RX7	expressed_in	gene	0.60
P2RX4	expressed_in	gene	0.60
LC3	inhibits	gene	0.60
CDKN1A	associated_with	gene	0.60
CTSB	associated_with	gene	0.60
ARNTL	associated_with	gene	0.60
COX4I1	activates	gene	0.60
GFAP	activates	gene	0.60
IBA1	activates	gene	0.60
LAMP2	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
NEFM	activates	gene	0.60
NFM	activates	gene	0.60
NPY	activates	gene	0.60
POMC	activates	gene	0.60
PRKN	activates	gene	0.60
RBFOX3	activates	gene	0.60
CANCER	activates	gene	0.60
Ampk Signaling	activates	pathway	0.60
MTORC1	inhibits	gene	0.60
CANCER	inhibits	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
ATP	inhibits	gene	0.60
Metastasis	inhibits	pathway	0.60
Autophagy	inhibits	pathway	0.60
Mtor	inhibits	pathway	0.60
Invasion	inhibits	pathway	0.60
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.60
CANCER	therapeutic_target	gene	0.60

Incoming (21)

Source	Relation	Type	Str
ARHGEF2	interacts_with	gene	0.80
GAIN	expressed_in	gene	0.60
TFEB	inhibits	gene	0.60
STAT3	associated_with	gene	0.60
KDM5A	associated_with	gene	0.60
TYRO3	associated_with	gene	0.60
SREBF1	associated_with	gene	0.60
AIF1	activates	gene	0.60
ARC	activates	gene	0.60
AMPK	activates	gene	0.60
GFP	inhibits	gene	0.60
ACETYL-COA	inhibits	gene	0.60
KRAS	inhibits	gene	0.60
FURIN	associated_with	gene	0.60
COMPLEMENT	associated_with	gene	0.60
RNA	associated_with	gene	0.60
FERROPTOSIS	associated_with	gene	0.60
AMPK	inhibits	gene	0.60
AMPK	protects_against	gene	0.60
AMPK	co_expressed_with	protein	0.50
ATP	co_expressed_with	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CAMKK2

Understanding Entity Pages

Summary

Wiki Pages (13)

CAMKK2 Gene

TYRO3 - TYRO3 Receptor Tyrosine Kinase

AMPK Signaling in Neurodegeneration

PRKAA2 (AMPKα2) — AMP-Activated Protein Kinase Catalytic Subunit Alpha 2

AMPK Signaling in Parkinson's Disease

AMPK Protein

STK11 Protein - LKB1 - Serine/Threonine Kinase 11

AMPK-Mitochondrial Quality Control Axis

RNA Binding Fox-3 Homolog (NeuN) (RBFOX3)

ARHGEF2 Gene

CAMKK2 Protein

Proteins