FYCO1 — FYVE and Coiled-Coil Domain Containing 1

FYCO1 — FYVE and Coiled-Coil Domain Containing 1

Introduction

<table class="infobox infobox-gene">
<tr>
<th class="infobox-header" colspan="2">FYCO1 — FYVE and Coiled-Coil Domain Containing 1</th>
</tr>
<tr>
<td class="label">Gene Symbol</td>
<td>FYCO1</td>
</tr>
<tr>
<td class="label">Full Name</td>
<td>FYVE and Coiled-Coil Domain Containing 1</td>
</tr>
<tr>
<td class="label">Chromosomal Location</td>
<td>3p21.2</td>
</tr>
<tr>
<td class="label">NCBI Gene ID</td>
<td>79443</td>
</tr>
<tr>
<td class="label">OMIM ID</td>
<td>607781</td>
</tr>
<tr>
<td class="label">Ensembl ID</td>
<td>ENSG00000164120</td>
</tr>
<tr>
<td class="label">UniProt ID</td>
<td>Q9BQR1</td>
</tr>
<tr>
<td class="label">Associated Diseases</td>
<td>Hereditary Spastic Paraplegia, Cataract, [Autophagy](/entities/autophagy) defects</td>
</tr>
</table>

Fyco1 — Fyve And Coiled Coil Domain Containing 1 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

Overview

FYCO1 — FYVE and Coiled-Coil Domain Containing 1

Introduction

<table class="infobox infobox-gene">
<tr>
<th class="infobox-header" colspan="2">FYCO1 — FYVE and Coiled-Coil Domain Containing 1</th>
</tr>
<tr>
<td class="label">Gene Symbol</td>
<td>FYCO1</td>
</tr>
<tr>
<td class="label">Full Name</td>
<td>FYVE and Coiled-Coil Domain Containing 1</td>
</tr>
<tr>
<td class="label">Chromosomal Location</td>
<td>3p21.2</td>
</tr>
<tr>
<td class="label">NCBI Gene ID</td>
<td>79443</td>
</tr>
<tr>
<td class="label">OMIM ID</td>
<td>607781</td>
</tr>
<tr>
<td class="label">Ensembl ID</td>
<td>ENSG00000164120</td>
</tr>
<tr>
<td class="label">UniProt ID</td>
<td>Q9BQR1</td>
</tr>
<tr>
<td class="label">Associated Diseases</td>
<td>Hereditary Spastic Paraplegia, Cataract, [Autophagy](/entities/autophagy) defects</td>
</tr>
</table>

Fyco1 — Fyve And Coiled Coil Domain Containing 1 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

Overview

This page provides comprehensive information about FYCO1 Gene, including its structure, normal function in the nervous system, and its role in neurodegenerative diseases.

Function

FYCO1 encodes a autophagy adapter protein that links autophagosomes to the microtubule-based transport machinery. FYCO1 contains multiple domains:

• FYVE domain - binds to phosphatidylinositol 3-phosphate (PI3P) on autophagosomal membranes
• Coiled-coil domains - mediate protein-protein interactions
• LC3-interacting region (LIR) - binds LC3/GABARAP proteins

Role in Autophagy

FYCO1 functions as a selective autophagy receptor that:

• Recruits autophagosomes to microtubules via interaction with RAB7 and RAB11
• Promotes autophagosome-lysosome fusion through SNARE complex interactions
• Coordinates cargo transport from peripheral to perinuclear regions
• Facilitates endosomal maturation and trafficking

Binding Partners

FYCO1 interacts with:

• LC3/GABARAP - autophagy proteins on autophagosomal membrane
• RAB7 - late endosomal/lysosomal GTPase
• RAB11 - recycling endosome GTPase
• PI3P - phosphoinositide on autophagosomes
• [mTOR](/entities/mtor) - regulates FYCO1 phosphorylation

Disease Associations

Hereditary Spastic Paraplegia (SPG59)

FYCO1 mutations cause autosomal recessive hereditary spastic paraplegia type 59 (SPG59). Clinical features include:

• Early-onset progressive spasticity in lower limbs
• Developmental delay
• Ocular abnormalities (cataracts)
• Peripheral neuropathy

• Impaired autophagic flux
• Accumulation of damaged organelles
• Axonal transport defects

Autophagy-Related Neurodegeneration

FYCO1 deficiency leads to:

• Impaired clearance of protein aggregates
• Mitochondrial dysfunction
• Lysosomal storage abnormalities
• Enhanced susceptibility to oxidative stress

Cataract

FYCO1 is highly expressed in the lens, and mutations cause congenital cataract, often accompanying spastic paraplegia in SPG59.

Expression

FYCO1 is expressed in:

• Brain (cerebral [cortex](/brain-regions/cortex), [hippocampus](/brain-regions/hippocampus), cerebellum)
• Retina
• Lens
• Liver
• Kidney
• Muscle

• Autophagosomes throughout the soma and axons
• Late endosomes/lysosomes
• Dendritic compartments

Key Publications

See Also

• [Hereditary Spastic Paraplegia](/diseases/hereditary-spastic-paraplegia)
• [Autophagy-Lysosomal Pathway](/mechanisms/autophagy-lysosomal-pathway)
• [Protein Quality Control](/mechanisms/protein-quality-control-network)
• [RAB Proteins](/entities/rab-proteins)
• [LC3/GABARAP](/entities/lc3-gabarap)
• [Axonal Transport](/mechanisms/axonal-transport)

External Links

• [NCBI Gene: FYCO1](https://www.ncbi.nlm.nih.gov/gene/79443)
• [UniProt: FYCO1](https://www.uniprot.org/uniprot/Q9BQR1)
• [OMIM: FYCO1](https://www.omim.org/entry/607781)
• [Allen Brain Atlas: FYCO1](https://human.brain-map.org/microarray/search/show?search_term=FYCO1)

Background

The study of Fyco1 — Fyve And Coiled Coil Domain Containing 1 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.

Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.

References

Pathway Diagram

The following diagram shows the key molecular relationships involving FYCO1 — FYVE and Coiled-Coil Domain Containing 1 discovered through SciDEX knowledge graph analysis: