gene 583 words KG: FYCO1 2026-03-16
kind:genesection:genesstate:published
Contents

FYCO1 — FYVE and Coiled-Coil Domain Containing 1

🧬 Gene Info
Gene SymbolFYCO1
Full NameFYVE and Coiled-Coil Domain Containing 1
Chromosome3p21.2
FunctionFYCO1 encodes a autophagy adapter protein that links autophagosomes to the microtubule-based transport machinery.
Primary Expressionthe lens, and mutations cause congenital cataract, often accompanying spastic paraplegia in SPG59
PathwaysmTOR, mtor
UniProt IDQ9BQR1
NCBI Gene ID79443
Ensembl IDENSG00000164120
OMIM607781
GeneCardsFYCO1
Human Protein AtlasFYCO1
Associated DiseasesCancer, Cardiovascular, Ischemia, Ms, Neurodegeneration, Parkinson
Known Drugs/Compoundsrapamycin
InteractionsTFEB, DR5, TRAIL, CASP8, TNF, BCL2
KG Connections170 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (11)

Purinergic Signaling Polarization Control
Score: 0.55
Mechanosensitive Ion Channel Reprogramming
Score: 0.51
Lipid Droplet Dynamics as Phenotype Switches
Score: 0.46
APOE-Dependent Autophagy Restoration
Score: 0.61
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.57

Related Analyses (8)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (15)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: associated_with
BECN1 Gene
gene · KG edge: activates
BCL2L1 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

FYCO1 activates GABARAP
FYCO1 activates GLA
FYCO1 activates HDAC6
FYCO1 activates LAMP2
FYCO1 activates MAP1LC3B
FYCO1 activates MTOR
FYCO1 activates PIK3C3
FYCO1 activates PSEN1
FYCO1 activates PSEN2
FYCO1 activates RAB9A