Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about 24S-Hydroxycholesterol: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| LXR activation | activates | pathway | 0.90 |
| LRX activation | activates | pathway | 0.90 |
| Cholesterol Elimination | mediates | process | 0.90 |
| Alzheimer'S Disease | correlates_with | disease | 0.85 |
| Neurodegeneration | biomarker_for | disease | 0.85 |
| compensatory upregulation | associated_with | process | 0.70 |
| SREBP signaling | modulates | pathway | 0.70 |
| amyloid pathology | prevents | mechanism | 0.70 |
| neuroprotection | causes | phenotype | 0.70 |
| Alzheimer's disease | associated_with | disease | 0.70 |
| Huntington's disease | associated_with | disease | 0.70 |
| neurotoxicity | causes | phenotype | 0.70 |
| neuronal function | modulates | process | 0.70 |
| neuronal viability | protective_against | phenotype | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CYP46A1 | causes | gene | 0.90 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 15 hypotheses Top: 0.852
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 6 · Score: 0.95 · 2026-04-27
closed · Rounds: 4 · Score: 0.50 · 2026-04-27
closed · Rounds: 4 · Score: 0.40 · 2026-04-27
closed · Rounds: 4 · Score: 0.40 · 2026-04-27
closed · Rounds: 5 · Score: 0.93 · 2026-04-11
Hypotheses and analyses mentioning 24S-Hydroxycholesterol in their description or question text
No additional research found