Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about 4r-tau: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | 4R-TAU |
| Protein Type | Protein |
| Function | Normal tau functions include[@weingarten1975]: |
| Primary Expression | Neurons (axons), astrocytes, oligodendrocytes |
| Molecular Weight | 65 kDa |
| Amino Acids | 441 aa |
| Pathways | Tdp-43 |
| UniProt ID | Search UniProt |
| Associated Diseases | psp |
| Interactions | 3r-tau |
| KG Connections | 8 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
n_4R_TAU["4R-TAU"]
n_4R_TAU -->|"expressed in"| TAU["TAU"]
n_4R_TAU -->|"activates"| Tdp_43["Tdp-43"]
n_4R_TAU -->|"activates"| TDP_43["TDP-43"]
n_4R_TAU -->|"expressed in"| Tau_Protein["Tau Protein"]
n_4R_TAU -->|"expressed in"| Insulin["Insulin"]
n_4R_TAU -->|"expressed in"| Neuron["Neuron"]
n_4R_TAU -->|"activates"| disease["disease"]
TDP_43 -->|"activates"| n_4R_TAU
n_3R_TAU["3R-TAU"] -->|"expressed in"| n_4R_TAU
AND["AND"] -->|"expressed in"| n_4R_TAU
n_3r_tau["3r-tau"] -->|"activates"| n_4R_TAU| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:4R-TAU | data_in | dataset_row | 0.00 |
| psp | causes | disease | 0.90 |
| CBD | causes | drug | 0.90 |
| tufted astrocytes | causes | cell_type | 0.70 |
| PSP | biomarker_for | disease | 0.70 |
| CBD | biomarker_for | disease | 0.70 |
| Tdp-43 | activates | pathway | 0.60 |
| Tau Protein | expressed_in | protein | 0.60 |
| Insulin | expressed_in | protein | 0.60 |
| AQP4 | inhibits | protein | 0.60 |
| TAU | expressed_in | gene | 0.60 |
| TDP-43 | activates | gene | 0.60 |
| Neuron | expressed_in | cell_type | 0.55 |
| Tdp-43 | activates | pathway | 0.50 |
| disease | activates | disease | 0.50 |
| NEURONS | activates | concept | 0.50 |
| NEURODEGENERATIVE DISEASE | activates | concept | 0.50 |
| INSULIN | activates | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:4R-TAU | data_in | dataset_row | 0.00 |
| TDP-43 | activates | gene | 0.60 |
| 3R-TAU | expressed_in | gene | 0.60 |
| 3r-tau | activates | protein | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-16 | 0 hypotheses
neurodegeneration | 2026-04-01 | 14 hypotheses Top: 0.732
neurodegeneration | 2026-04-01 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.70 · 2026-04-21
closed · Rounds: 4 · Score: 0.70 · 2026-04-16
closed · Rounds: 4 · Score: 0.69 · 2026-04-12
closed · Rounds: 7 · Score: 0.91 · 2026-04-10
closed · Rounds: 4 · Score: 0.95 · 2026-04-01
Hypotheses and analyses mentioning 4r-tau in their description or question text
No additional research found