protein

ABCD1PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ABCD1PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

X-ALD affects approximately 1 in 21,000 males, making it the most common inherited peroxisomal disorder.

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🔬 Protein Info

Gene Symbol	ABCD1PROTEIN
Protein Family	ABC transporter family D
Protein Type	Transporter
Function	is a peroxisomal membrane transporter protein essential for the import of very long-chain fatty acids (VLCFAs) into peroxisomes for β-oxidation[@mosser1993].
Molecular Weight	~66 kDa
Amino Acids	660 amino acids
UniProt ID	P33897
GeneCards	ABCD1PROTEIN
Human Protein Atlas	ABCD1PROTEIN
Six transmembrane helices	Form the translocation pore
Peroxisomal membrane topology	N- and C-termini face the cytosol
Substrate binding pocket	Located within the membrane
N-terminal NBD	Binds and hydrolyzes ATP
Walker A motif	Phosphate-binding loop (P-loop)
Walker B motif	Coordinates Mg²⁺ ion
Associated Diseases	Als, Ms
Interactions	ABCD2, ABCD3, ATP, BLOOD-BRAIN BARRIER DYSFUNCTION, CLDN5, CTNNB1
KG Connections	41 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: ABCD1PROTEIN — AlphaFold P33897 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

abcd1-protein

protein · 1110 words

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Pathway Diagram

graph TD
    ABCD1PROTEIN["ABCD1PROTEIN"]
    neurodegeneration["neurodegeneration"]
    ABCD1PROTEIN -->|"implicated_in"| neurodegeneration
    style ABCD1PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning ABCD1PROTEIN in their description or question text

No additional research found