Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about abcd2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ABCD2 |
| Full Name | ATP Binding Cassette Subfamily D Member 2 |
| Chromosome | 12q12 |
| Protein Type | Transporter |
| Function | is a peroxisomal ATP-binding cassette transporter primarily involved in the import of very long-chain fatty acids (VLCFAs) and branched-chain fatty acids into peroxisomes for beta-oxidation[@berger... |
| Primary Expression | brain white matter, liver, and adrenal glands |
| Amino Acids | 706 aa |
| Ensembl ID | ENSG00000173208 |
| GeneCards | ABCD2 |
| Human Protein Atlas | ABCD2 |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
ABCD2["ABCD2"]
ABCD2 -->|"activates"| Als["Als"]
ABCD2 -->|"expressed in"| Inflammation["Inflammation"]
ABCD2 -->|"target for"| Proteasome["Proteasome"]
ABCD2 -->|"expressed in"| INFLAMMATION["INFLAMMATION"]
ABCD2 -->|"activates"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
ABCD3["ABCD3"] -->|"activates"| ABCD2
ABCD1["ABCD1"] -->|"activates"| ABCD2
CTNNB1["CTNNB1"] -->|"activates"| ABCD2
ICAM1["ICAM1"] -->|"activates"| ABCD2| Target | Relation | Type | Str |
|---|---|---|---|
| Als | activates | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Inflammation | expressed_in | disease | 0.65 |
| Inflammation | activates | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| NR1H3 | expressed_in | gene | 0.60 |
| ABCD1 | associated_with | gene | 0.60 |
| ABCD1 | expressed_in | gene | 0.60 |
| CLDN5 | activates | gene | 0.60 |
| MMP9 | activates | gene | 0.60 |
| MYC | activates | gene | 0.60 |
| Proteasome | therapeutic_target | pathway | 0.60 |
| INFLAMMATION | expressed_in | gene | 0.60 |
| INFLAMMATION | activates | gene | 0.60 |
| OXIDATIVE STRESS | activates | gene | 0.60 |
| Oxidative Stress | activates | pathway | 0.60 |
| Cholesterol | activates | pathway | 0.60 |
| BLOOD-BRAIN BARRIER DYSFUNCTION | activates | gene | 0.60 |
| Blood-Brain Barrier | activates | pathway | 0.60 |
| benchmark_ot_ad_answer_key:ABCD2 | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ABCD3 | activates | gene | 0.60 |
| ABCD1 | activates | gene | 0.60 |
| ABCD3 | contributes_to | gene | 0.60 |
| ABCD1 | contributes_to | gene | 0.60 |
| ABCD3 | expressed_in | gene | 0.60 |
| ABCD1 | expressed_in | gene | 0.60 |
| CTNNB1 | activates | gene | 0.60 |
| ABCD3 | associated_with | gene | 0.60 |
| ABCD1 | associated_with | gene | 0.60 |
| ICAM1 | activates | gene | 0.60 |
| benchmark_ot_ad_answer_key:ABCD2 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||