gene

ABCD3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ABCD3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

474Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

ABCD3 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, expressed in, regulates. Associated with AD, ALI, ALS. Connected to 242 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ABCD3
Full Name	ATP-Binding Cassette Subfamily D Member 3
Chromosome	1p22.1
Protein Family	ABC transporter subfamily D
Protein Type	Transporter
Function	ABCD3 functions as a peroxisomal membrane transporter
Primary Expression	multiple tissues, with highest levels in liver, kidney, and brain
Subcellular Localization	Peroxisomal membrane
Molecular Weight	~79 kDa
Pathways	Tgf-Beta, Wnt
UniProt ID	[O75323](https://www.uniprot.org/uniprot/O75323)
GeneCards	ABCD3
Human Protein Atlas	ABCD3
Location	Chromosome 1p22.1
Protein Class	ABC transporter (peroxisomal)
Associated Diseases	AD, ALI, ALS, Alzheimer, Cancer
Interactions	FIP200, RTN3, SESN2, LMNA, MAP1LC3B, OPTN
KG Connections	474 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (18)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ABCD3["ABCD3"] -->|"interacts"| Dementia["Dementia"]
    ABCD3["ABCD3"] -->|"interacts"| Cardiovascular["Cardiovascular"]
    ABCD3["ABCD3"] -->|"interacts"| Als["Als"]
    ABCD3["ABCD3"] -->|"interacts"| Alzheimer["Alzheimer"]
    ABCD3["ABCD3"] -->|"interacts"| Parkinson["Parkinson"]
    ABCD3["ABCD3"] -->|"interacts"| Ms["Ms"]
    CAT["CAT"] -->|"interacts"| ABCD3["ABCD3"]
    OPTN["OPTN"] -->|"interacts"| ABCD3["ABCD3"]
    DNM1L["DNM1L"] -->|"interacts"| ABCD3["ABCD3"]
    CANX["CANX"] -->|"interacts"| ABCD3["ABCD3"]
    style ABCD3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (376)

Target	Relation	Type	Str
Dementia	interacts_with	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Frontotemporal Dementia	interacts_with	disease	0.65
Ftd	interacts_with	disease	0.65
Ms	regulates	disease	0.65
Cancer	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Als	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Inflammation	expressed_in	disease	0.65
Aging	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Hypertension	therapeutic_target	disease	0.65
Stroke	therapeutic_target	disease	0.65
Diabetes	regulates	disease	0.65
Als	regulates	disease	0.65
Carcinoma	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Tumor	interacts_with	disease	0.65
Als	expressed_in	disease	0.65
Carcinoma	associated_with	disease	0.65
Inflammation	activates	disease	0.65
Carcinoma	activates	disease	0.65
Cancer	regulates	disease	0.65
Tumor	regulates	disease	0.65
Als	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
ALS	interacts_with	disease	0.65
FIP200	interacts_with	gene	0.60
RTN3	interacts_with	gene	0.60
SESN2	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
MAP1LC3B	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
AMBRA1	interacts_with	gene	0.60
CTSD	interacts_with	gene	0.60
MUL1	interacts_with	gene	0.60
PARKIN	interacts_with	gene	0.60
PRKN	interacts_with	gene	0.60
BNIP3L	interacts_with	gene	0.60
HIF1A	interacts_with	gene	0.60
GBA	interacts_with	gene	0.60
BCL2	interacts_with	gene	0.60

Incoming (98)

Source	Relation	Type	Str
CAT	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
DNM1L	interacts_with	gene	0.60
CANX	interacts_with	gene	0.60
LGALS3	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
PEX3	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
BCL2	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
TAX1BP1	interacts_with	gene	0.60
ATM	interacts_with	gene	0.60
SNCAIP	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
MFN1	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
PARKIN	interacts_with	gene	0.60
FMR1	interacts_with	gene	0.60
SNCA	interacts_with	gene	0.60
FAM134B	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
EPAS1	interacts_with	gene	0.60
MIRO1	interacts_with	gene	0.60
CTSD	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
EIF2AK3	interacts_with	gene	0.60
PRKN	interacts_with	gene	0.60
BCL2L11	interacts_with	gene	0.60
MUL1	interacts_with	gene	0.60
BNIP3	interacts_with	gene	0.60
DISC1	interacts_with	gene	0.60
EIF2S1	interacts_with	gene	0.60
RIPK3	interacts_with	gene	0.60
DRP1	interacts_with	gene	0.60
CHOP	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
PTEN	interacts_with	gene	0.60
DDIT3	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
EMD	interacts_with	gene	0.60
MAPK8	interacts_with	gene	0.60
RHOT1	interacts_with	gene	0.60
BNIP3L	interacts_with	gene	0.60
NDP52	interacts_with	gene	0.60
HIF1A	interacts_with	gene	0.60
MAP1LC3B	interacts_with	gene	0.60
GBA	interacts_with	gene	0.60
FUNDC1	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ABCD3

Understanding Entity Pages

Summary

Wiki Pages (18)

ABCD3 Gene

GBA Gene Mutations and Parkinson's Disease Risk

ABCD1 — ATP Binding Cassette Subfamily D Member 1

USH1C Gene

Peroxisomal Dysfunction Hypothesis in Parkinson's Disease

slc22a5

Peroxisome Signaling Pathway in Neurodegeneration

peroxisome-dysfunction-4r-tauopathies

ABCD2 — ATP Binding Cassette Subfamily D Member 2

abcd1-protein

X-Linked Adrenoleukodystrophy (X-ALD) Genetic Variants

Genes Overview

Proteins Overview

ABCD2 Protein

ABCD3 Protein

COX10 Gene