protein

ACO2PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ACO2PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

ACO2 is encoded by the ACO2 gene and is essential for normal mitochondrial function. The enzyme is distinct from the cytosolic aconitase (ACO1), which functions in iron regulatory protein (IRP) post-transcriptional regulation.

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🔬 Protein Info

Gene Symbol	ACO2PROTEIN
Protein Family	Iron-sulfur isomerase (Aconitase) family
Protein Type	Enzyme
Function	is an iron-sulfur cluster-containing enzyme that catalyzes the reversible isomerization of citrate to isocitrate in the citric acid (TCA) cycle[@lill1999].
Molecular Weight	~82 kDa
Amino Acids	780 aa
UniProt ID	Q99798
GeneCards	ACO2PROTEIN
Human Protein Atlas	ACO2PROTEIN
Cluster composition	Four iron atoms coordinated by four inorganic sulfides
Cysteine ligands	Cys358, Cys360, Cys365, and Cys391 coordinate the cluster
Catalytic role	The cluster acts as a Lewis acid, facilitating citrate isomerization
Sensitivity	The cluster is highly sensitive to oxidative stress and nitric oxide
N-terminal domain	Contains the active site with the 4Fe-4S cluster
C-terminal domain	Forms a beta-barrel structure supporting the active site
Associated Diseases	neurodegeneration
Interactions	ATP, ATP5A1, CYCS, GLUD1, HSPA9, IMMUNE INFILTRATION
KG Connections	81 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: ACO2PROTEIN — AlphaFold Q99798 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

aco2-protein

protein · 1242 words

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Pathway Diagram

graph TD
    ACO2PROTEIN["ACO2PROTEIN"]
    neurodegeneration["neurodegeneration"]
    ACO2PROTEIN -->|"implicated_in"| neurodegeneration
    style ACO2PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning ACO2PROTEIN in their description or question text

No additional research found