gene

ATP5A1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATP5A1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

81Connections
0Hypotheses
0Analyses
50Outgoing
28Incoming

Summary

ATP5A1 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, therapeutic target, implicated in. Associated with Alzheimer, Huntington, Ms. Connected to 25 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolATP5A1
Full NameATP Synthase Subunit Alpha
Chromosome21q21.3
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight60 kDa
Amino Acids553 aa
UniProt ID[P25788](https://www.uniprot.org/uniprot/P25788)
Ensembl IDENSG00000188039
GeneCardsATP5A1
Human Protein AtlasATP5A1
Protein Size553 amino acids, ~60 kDa
TopologyMatrix-facing F1 domain
Oligomeric StateForms part of the alpha3beta3 hexamer with 3 alpha (ATP5A1) and 3 beta (ATP5B) subunits
Post-translational ModificationsKnown to be phosphorylated and acetylated, affecting enzyme activity and assembly
Associated Diseasesneurodegeneration
InteractionsSOD1, EGFR, GRIA1, MAPK1, ACTG1, YWHAZ
KG Connections81 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (11)

Knowledge base pages for this entity

Canonical Page

ATP5A1 Gene

gene · 1028 words

atp5b

gene · 2688 words

Proteomics of Progressive Supranuclear Palsy

mechanism · 1676 words

Mitochondrial Permeability Transition Pore (mPTP) in Neurodegeneration

mechanism · 1492 words

Mitochondrial ATP Synthesis

mechanism · 1381 words

PSMA3 Gene

gene · 876 words

Pathway Diagram

graph TD
    ATP5A1["<b>ATP5A1</b>"]
    Parkinson{"Parkinson"}
    ATP5A1 -->|"therapeutic target"| Parkinson
    Alzheimer{"Alzheimer"}
    ATP5A1 -->|"therapeutic target"| Alzheimer
    Huntington{"Huntington"}
    ATP5A1 -->|"therapeutic target"| Huntington
    Ms{"Ms"}
    ATP5A1 -->|"therapeutic target"| Ms
    SOD1["SOD1"]
    ATP5A1 -->|"interacts with"| SOD1
    EGFR["EGFR"]
    ATP5A1 -->|"interacts with"| EGFR
    Blood_Brain_Barrier(["Blood-Brain Barrier"])
    ATP5A1 -->|"therapeutic target"| Blood_Brain_Barrier
    Mapk(["Mapk"])
    ATP5A1 -->|"interacts with"| Mapk
    neurodegeneration["neurodegeneration"]
    ATP5A1 -->|"implicated in"| neurodegeneration
    CCT2["CCT2"]
    CCT2 -->|"interacts with"| ATP5A1
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"therapeutic target"| ATP5A1
    GFAP["GFAP"]
    GFAP -->|"interacts with"| ATP5A1
    GRIA1["GRIA1"]
    GRIA1 -->|"interacts with"| ATP5A1
    SNAP25["SNAP25"]
    SNAP25 -->|"interacts with"| ATP5A1
    ACTG1["ACTG1"]
    ACTG1 -->|"interacts with"| ATP5A1
    SNCA["SNCA"]
    SNCA -->|"interacts with"| ATP5A1
    GAPDH["GAPDH"]
    GAPDH -->|"interacts with"| ATP5A1
    MAPK1["MAPK1"]
    MAPK1 -->|"interacts with"| ATP5A1
    PSMA3["PSMA3"]
    PSMA3 -->|"interacts with"| ATP5A1
    SOX2["SOX2"]
    SOX2 -->|"interacts with"| ATP5A1
    YWHAZ["YWHAZ"]
    YWHAZ -->|"interacts with"| ATP5A1
    style ATP5A1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (53)

TargetRelationTypeStr
ATP synthesisinvolved_inpathway0.92
energy metabolismdownregulatesprocess0.83
Parkinsontherapeutic_targetdisease0.65
Alzheimertherapeutic_targetdisease0.65
Huntingtontherapeutic_targetdisease0.65

Incoming (28)

SourceRelationTypeStr
PS-COOHdownregulatescompound0.90
CCT2interacts_withgene0.60
GFAPinteracts_withgene0.60
GRIA1interacts_withgene0.60
SNAP25interacts_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found