Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ATP5A1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
ATP5A1 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, therapeutic target, implicated in. Associated with Alzheimer, Huntington, Ms. Connected to 25 entities in the SciDEX knowledge graph.
| Gene Symbol | ATP5A1 |
| Full Name | ATP Synthase Subunit Alpha |
| Chromosome | 21q21.3 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | 60 kDa |
| Amino Acids | 553 aa |
| UniProt ID | [P25788](https://www.uniprot.org/uniprot/P25788) |
| Ensembl ID | ENSG00000188039 |
| GeneCards | ATP5A1 |
| Human Protein Atlas | ATP5A1 |
| Protein Size | 553 amino acids, ~60 kDa |
| Topology | Matrix-facing F1 domain |
| Oligomeric State | Forms part of the alpha3beta3 hexamer with 3 alpha (ATP5A1) and 3 beta (ATP5B) subunits |
| Post-translational Modifications | Known to be phosphorylated and acetylated, affecting enzyme activity and assembly |
| Associated Diseases | neurodegeneration |
| Interactions | SOD1, EGFR, GRIA1, MAPK1, ACTG1, YWHAZ |
| KG Connections | 81 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
ATP5A1["<b>ATP5A1</b>"]
Parkinson{"Parkinson"}
ATP5A1 -->|"therapeutic target"| Parkinson
Alzheimer{"Alzheimer"}
ATP5A1 -->|"therapeutic target"| Alzheimer
Huntington{"Huntington"}
ATP5A1 -->|"therapeutic target"| Huntington
Ms{"Ms"}
ATP5A1 -->|"therapeutic target"| Ms
SOD1["SOD1"]
ATP5A1 -->|"interacts with"| SOD1
EGFR["EGFR"]
ATP5A1 -->|"interacts with"| EGFR
Blood_Brain_Barrier(["Blood-Brain Barrier"])
ATP5A1 -->|"therapeutic target"| Blood_Brain_Barrier
Mapk(["Mapk"])
ATP5A1 -->|"interacts with"| Mapk
neurodegeneration["neurodegeneration"]
ATP5A1 -->|"implicated in"| neurodegeneration
CCT2["CCT2"]
CCT2 -->|"interacts with"| ATP5A1
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
ALZHEIMER_S_DISEASE -->|"therapeutic target"| ATP5A1
GFAP["GFAP"]
GFAP -->|"interacts with"| ATP5A1
GRIA1["GRIA1"]
GRIA1 -->|"interacts with"| ATP5A1
SNAP25["SNAP25"]
SNAP25 -->|"interacts with"| ATP5A1
ACTG1["ACTG1"]
ACTG1 -->|"interacts with"| ATP5A1
SNCA["SNCA"]
SNCA -->|"interacts with"| ATP5A1
GAPDH["GAPDH"]
GAPDH -->|"interacts with"| ATP5A1
MAPK1["MAPK1"]
MAPK1 -->|"interacts with"| ATP5A1
PSMA3["PSMA3"]
PSMA3 -->|"interacts with"| ATP5A1
SOX2["SOX2"]
SOX2 -->|"interacts with"| ATP5A1
YWHAZ["YWHAZ"]
YWHAZ -->|"interacts with"| ATP5A1
style ATP5A1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| ATP synthesis | involved_in | pathway | 0.92 |
| energy metabolism | downregulates | process | 0.83 |
| Parkinson | therapeutic_target | disease | 0.65 |
| Alzheimer | therapeutic_target | disease | 0.65 |
| Huntington | therapeutic_target | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| Prion | therapeutic_target | disease | 0.65 |
| SOD1 | interacts_with | gene | 0.60 |
| EGFR | interacts_with | gene | 0.60 |
| GRIA1 | interacts_with | gene | 0.60 |
| MAPK1 | interacts_with | gene | 0.60 |
| ACTG1 | interacts_with | gene | 0.60 |
| YWHAZ | interacts_with | gene | 0.60 |
| CALCOCO2 | activates | gene | 0.60 |
| HSP60 | activates | gene | 0.60 |
| HSPD1 | activates | gene | 0.60 |
| MAP1LC3B | activates | gene | 0.60 |
| NDP52 | activates | gene | 0.60 |
| OPTN | activates | gene | 0.60 |
| PARL | activates | gene | 0.60 |
| PHB2 | activates | gene | 0.60 |
| PINK1 | activates | gene | 0.60 |
| PRKN | activates | gene | 0.60 |
| PTEN | activates | gene | 0.60 |
| TOMM20 | activates | gene | 0.60 |
| TUBB | activates | gene | 0.60 |
| cancer | activates | disease | 0.60 |
| MDH2 | interacts_with | gene | 0.60 |
| NDUFS3 | interacts_with | gene | 0.60 |
| PDHB | interacts_with | gene | 0.60 |
| SDHA | interacts_with | gene | 0.60 |
| SUCLG1 | interacts_with | gene | 0.60 |
| CCT2 | interacts_with | gene | 0.60 |
| CDC42 | interacts_with | gene | 0.60 |
| GAPDH | interacts_with | gene | 0.60 |
| GFAP | interacts_with | gene | 0.60 |
| HSP90AB1 | interacts_with | gene | 0.60 |
| PSMA3 | interacts_with | gene | 0.60 |
| SNAP25 | interacts_with | gene | 0.60 |
| SNCA | interacts_with | gene | 0.60 |
| SOX2 | interacts_with | gene | 0.60 |
| Blood-Brain Barrier | therapeutic_target | pathway | 0.60 |
| Mapk | interacts_with | pathway | 0.60 |
| ALZHEIMER'S DISEASE | therapeutic_target | gene | 0.60 |
| COX2 | activates | gene | 0.60 |
| LC3B | activates | gene | 0.60 |
| PGAM5 | activates | gene | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| apoptosis pathway | participates_in | pathway | 0.60 |
| ubiquitin-proteasome | participates_in | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PS-COOH | downregulates | compound | 0.90 |
| CCT2 | interacts_with | gene | 0.60 |
| GFAP | interacts_with | gene | 0.60 |
| GRIA1 | interacts_with | gene | 0.60 |
| SNAP25 | interacts_with | gene | 0.60 |
| ACTG1 | interacts_with | gene | 0.60 |
| SNCA | interacts_with | gene | 0.60 |
| GAPDH | interacts_with | gene | 0.60 |
| MAPK1 | interacts_with | gene | 0.60 |
| PSMA3 | interacts_with | gene | 0.60 |
| SOX2 | interacts_with | gene | 0.60 |
| YWHAZ | interacts_with | gene | 0.60 |
| HSP90AB1 | interacts_with | gene | 0.60 |
| ACTB | interacts_with | gene | 0.60 |
| CDC42 | interacts_with | gene | 0.60 |
| SOD1 | interacts_with | gene | 0.60 |
| EGFR | interacts_with | gene | 0.60 |
| AIFM1 | activates | gene | 0.60 |
| ACO2 | interacts_with | gene | 0.60 |
| ALZHEIMER'S DISEASE | therapeutic_target | gene | 0.60 |
| FN1 | interacts_with | gene | 0.60 |
| PARKINSON | therapeutic_target | gene | 0.60 |
| HUNTINGTON | therapeutic_target | gene | 0.60 |
| ALZHEIMER | therapeutic_target | gene | 0.60 |
| PSMD14 | interacts_with | gene | 0.60 |
| AND | interacts_with | gene | 0.60 |
| GENES | interacts_with | gene | 0.60 |
| ATP | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||