gene

HSPA9

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HSPA9: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

180Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

HSPA9 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, therapeutic target, regulates. Associated with Cancer, Heart Failure, Ms. Connected to 67 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	HSPA9
Chromosome	5q31.2.
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	most cell lines
Molecular Weight	73.6 kDa
Amino Acids	679 aa
Pathways	Apoptosis, Oxidative Phosphorylation
Ensembl ID	ENSG00000113014
GeneCards	HSPA9
Human Protein Atlas	HSPA9
Brain	High expression in neurons, especially dopaminergic neurons
Associated Diseases	Parkinson
Interactions	aco2, ACO2, AKT, ATP, BECN1, BNIP3
KG Connections	180 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

HSPA9 Gene

gene · 630 words

→

HSPA9 Protein

protein · 852 words

→

Pathway Diagram

flowchart TD
    HSPA9["HSPA9"] -->|"therapeutic target"| Parkinson["Parkinson"]
    HSPA9["HSPA9"] -.->|"inhibits"| Heart_Failure["Heart Failure"]
    HSPA9["HSPA9"] -.->|"inhibits"| Ms["Ms"]
    HSPA9["HSPA9"] -->|"activates"| Cancer["Cancer"]
    HSPA9["HSPA9"] -->|"activates"| Tumor["Tumor"]
    HSPA9["HSPA9"] -->|"expressed in"| CYCS["CYCS"]
    HSPA9["HSPA9"] -->|"therapeutic target"| IMMUNE_INFILTRATION["IMMUNE INFILTRATION"]
    HSPA9["HSPA9"] -->|"expressed in"| ACO2["ACO2"]
    HSPA9["HSPA9"] -->|"therapeutic target"| GLUD1["GLUD1"]
    HSPA9["HSPA9"] -->|"expressed in"| SNCA["SNCA"]
    HSPA9["HSPA9"] -->|"therapeutic target"| LRPPRC["LRPPRC"]
    HSPA9["HSPA9"] -->|"therapeutic target"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    style HSPA9 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Parkinson fill:#ef5350,stroke:#333,color:#e0e0e0
    style Heart_Failure fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cancer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Tumor fill:#ef5350,stroke:#333,color:#e0e0e0
    style CYCS fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style IMMUNE_INFILTRATION fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style ACO2 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style GLUD1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style SNCA fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style LRPPRC fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style OXIDATIVE_STRESS fill:#4a1a6b,stroke:#333,color:#e0e0e0

Outgoing (110)

Target	Relation	Type	Str
Parkinson'S Disease	downregulates	disease	0.75
Parkin translocation to healthy mitochondria	prevents	mechanism	0.70
mitochondrial protein import	stabilizes	process	0.70
Glioblastoma	activates	disease	0.65
Heart Failure	inhibits	disease	0.65
Cancer	activates	disease	0.65
Parkinson	activates	disease	0.65
Ms	inhibits	disease	0.65
Tumor	activates	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Als	activates	disease	0.65
ALS	activates	disease	0.65
HTRA2	inhibits	gene	0.60
SIRT1	inhibits	gene	0.60
NDUFS1	therapeutic_target	gene	0.60
BNIP3L	inhibits	gene	0.60
LAMP2	inhibits	gene	0.60
NDUFS2	therapeutic_target	gene	0.60
GLUD1	therapeutic_target	gene	0.60
LRPPRC	therapeutic_target	gene	0.60
TIMM10	inhibits	gene	0.60
Oxidative Phosphorylation	therapeutic_target	pathway	0.60
UBIQUITIN	regulates	gene	0.60
KEAP1	regulates	gene	0.60
VDAC1	expressed_in	gene	0.60
GBM	activates	gene	0.60
OMA1	activates	gene	0.60
CGAS	activates	gene	0.60
STING	activates	gene	0.60
NDUFS1	activates	gene	0.60
ULK1	inhibits	gene	0.60
TFAM	inhibits	gene	0.60
HSPE1	inhibits	gene	0.60
Oxidative Stress	therapeutic_target	pathway	0.60
SDHA	targets	gene	0.60
OMA1	targets	gene	0.60
EIF2A	inhibits	gene	0.60
TIMM22	inhibits	gene	0.60
SNCA	targets	gene	0.60
VDAC1	targets	gene	0.60
SNCA	activates	gene	0.60
VDAC1	activates	gene	0.60
SNCA	associated_with	gene	0.60
VDAC1	associated_with	gene	0.60
DNM1L	inhibits	gene	0.60
OPA1	inhibits	gene	0.60
HSPD1	activates	gene	0.60
YME1L1	activates	gene	0.60
JNK	activates	gene	0.60
TIMM17A	inhibits	gene	0.60

Incoming (70)

Source	Relation	Type	Str
OMA1	binds	gene	0.80
OMA1	binds_to	gene	0.80
BNIP3	inhibits	gene	0.60
VDAC1	inhibits	gene	0.60
FUNDC1	inhibits	gene	0.60
TOMM20	inhibits	gene	0.60
TIMM9	inhibits	gene	0.60
TIMM17B	inhibits	gene	0.60
OMA1	inhibits	gene	0.60
TIMM23	inhibits	gene	0.60
MTOR	inhibits	gene	0.60
NRF1	inhibits	gene	0.60
HSPD1	inhibits	gene	0.60
MFN2	inhibits	gene	0.60
MFF	inhibits	gene	0.60
BECN1	inhibits	gene	0.60
LONP1	inhibits	gene	0.60
SPG7	inhibits	gene	0.60
MAP1LC3A	inhibits	gene	0.60
DDIT3	inhibits	gene	0.60
JUN	inhibits	gene	0.60
TIMM50	inhibits	gene	0.60
SNCA	expressed_in	gene	0.60
NDUFS1	therapeutic_target	gene	0.60
CYCS	expressed_in	gene	0.60
GBM	activates	gene	0.60
OMA1	activates	gene	0.60
LRPPRC	activates	gene	0.60
GLUD1	activates	gene	0.60
ACO2	expressed_in	gene	0.60
GLIOBLASTOMA	activates	gene	0.60
CEBPB	inhibits	gene	0.60
OXIDATIVE STRESS	therapeutic_target	gene	0.60
GENES	therapeutic_target	gene	0.60
IMMUNE INFILTRATION	therapeutic_target	gene	0.60
ATP	therapeutic_target	gene	0.60
MITOPHAGY	activates	gene	0.60
ROS	therapeutic_target	gene	0.60
HUB GENES	associated_with	gene	0.60
DNA	activates	gene	0.60
CGAS-STING	activates	gene	0.60
PD-L1	associated_with	gene	0.60
VDAC1	expressed_in	gene	0.60
LRPPRC	therapeutic_target	gene	0.60
GLUD1	therapeutic_target	gene	0.60
NDUFS2	therapeutic_target	gene	0.60
GBM	targets	gene	0.60
ACO2	targets	gene	0.60
CYCS	targets	gene	0.60
ACO2	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Do PINK1/PARKIN pathway enhancements rescue excitatory neuron vulnerability or c

neurodegeneration | 2026-04-11 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The debate revealed a critical gap: while excitatory neurons show mitochondrial

closed · Rounds: 4 · Score: 0.50 · 2026-04-20

Related Research

Hypotheses and analyses mentioning HSPA9 in their description or question text

No additional research found