gene

HSPA9

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HSPA9: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

180Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

HSPA9 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, therapeutic target, regulates. Associated with Cancer, Heart Failure, Ms. Connected to 67 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	HSPA9
Chromosome	5q31.2.
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	most cell lines
Molecular Weight	73.6 kDa
Amino Acids	679 aa
Pathways	Apoptosis, Oxidative Phosphorylation
Ensembl ID	ENSG00000113014
GeneCards	HSPA9
Human Protein Atlas	HSPA9
Associated Diseases	Parkinson
Interactions	TIMM22, HSPE1, OPA1, LAMP2, BNIP3L, SIRT1
KG Connections	180 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    HSPA9["HSPA9"] -->|"therapeutic target"| Parkinson["Parkinson"]
    HSPA9["HSPA9"] -.->|"inhibits"| Heart_Failure["Heart Failure"]
    HSPA9["HSPA9"] -.->|"inhibits"| Ms["Ms"]
    HSPA9["HSPA9"] -->|"activates"| Cancer["Cancer"]
    HSPA9["HSPA9"] -->|"activates"| Tumor["Tumor"]
    HSPA9["HSPA9"] -->|"expressed in"| CYCS["CYCS"]
    HSPA9["HSPA9"] -->|"therapeutic target"| IMMUNE_INFILTRATION["IMMUNE INFILTRATION"]
    HSPA9["HSPA9"] -->|"expressed in"| ACO2["ACO2"]
    HSPA9["HSPA9"] -->|"therapeutic target"| GLUD1["GLUD1"]
    HSPA9["HSPA9"] -->|"expressed in"| SNCA["SNCA"]
    HSPA9["HSPA9"] -->|"therapeutic target"| LRPPRC["LRPPRC"]
    HSPA9["HSPA9"] -->|"therapeutic target"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    style HSPA9 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Parkinson fill:#ef5350,stroke:#333,color:#e0e0e0
    style Heart_Failure fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cancer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Tumor fill:#ef5350,stroke:#333,color:#e0e0e0
    style CYCS fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style IMMUNE_INFILTRATION fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style ACO2 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style GLUD1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style SNCA fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style LRPPRC fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style OXIDATIVE_STRESS fill:#4a1a6b,stroke:#333,color:#e0e0e0

Outgoing (110)

Target	Relation	Type	Str
Parkinson'S Disease	downregulates	disease	0.75
Parkinson	therapeutic_target	disease	0.65
Heart Failure	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Als	activates	disease	0.65
Glioblastoma	activates	disease	0.65
ALS	activates	disease	0.65
Parkinson	activates	disease	0.65
CYCS	expressed_in	gene	0.60
ACO2	expressed_in	gene	0.60
GLUD1	therapeutic_target	gene	0.60
SNCA	expressed_in	gene	0.60
LRPPRC	therapeutic_target	gene	0.60
NDUFS2	therapeutic_target	gene	0.60
NDUFS1	therapeutic_target	gene	0.60
SDHA	expressed_in	gene	0.60
TIMM22	inhibits	gene	0.60
HSPE1	inhibits	gene	0.60
OPA1	inhibits	gene	0.60
LAMP2	inhibits	gene	0.60
BNIP3L	inhibits	gene	0.60
SIRT1	inhibits	gene	0.60
HTRA2	inhibits	gene	0.60
PARK2	inhibits	gene	0.60
PINK1	inhibits	gene	0.60
TIMM17A	inhibits	gene	0.60
EIF2A	inhibits	gene	0.60
TFAM	inhibits	gene	0.60
ULK1	inhibits	gene	0.60
TIMM10	inhibits	gene	0.60
DNM1L	inhibits	gene	0.60
UBIQUITIN	regulates	gene	0.60
KEAP1	regulates	gene	0.60
VDAC1	expressed_in	gene	0.60
GBM	activates	gene	0.60
OMA1	activates	gene	0.60
CGAS	activates	gene	0.60
STING	activates	gene	0.60
NDUFS1	activates	gene	0.60
NDUFS2	activates	gene	0.60
OMA1	targets	gene	0.60
SDHA	targets	gene	0.60
SNCA	targets	gene	0.60
VDAC1	targets	gene	0.60
SNCA	activates	gene	0.60
VDAC1	activates	gene	0.60
SNCA	associated_with	gene	0.60
VDAC1	associated_with	gene	0.60

Incoming (70)

Source	Relation	Type	Str
OMA1	binds	gene	0.80
OMA1	binds_to	gene	0.80
VDAC1	expressed_in	gene	0.60
BNIP3	inhibits	gene	0.60
VDAC1	inhibits	gene	0.60
FUNDC1	inhibits	gene	0.60
TOMM20	inhibits	gene	0.60
TIMM9	inhibits	gene	0.60
TIMM17B	inhibits	gene	0.60
OMA1	inhibits	gene	0.60
TIMM23	inhibits	gene	0.60
MTOR	inhibits	gene	0.60
NRF1	inhibits	gene	0.60
HSPD1	inhibits	gene	0.60
MFN2	inhibits	gene	0.60
MFF	inhibits	gene	0.60
BECN1	inhibits	gene	0.60
LONP1	inhibits	gene	0.60
CEBPB	inhibits	gene	0.60
SPG7	inhibits	gene	0.60
MAP1LC3A	inhibits	gene	0.60
DDIT3	inhibits	gene	0.60
JUN	inhibits	gene	0.60
TIMM50	inhibits	gene	0.60
SNCA	expressed_in	gene	0.60
NDUFS1	therapeutic_target	gene	0.60
CYCS	expressed_in	gene	0.60
GBM	activates	gene	0.60
OMA1	activates	gene	0.60
LRPPRC	activates	gene	0.60
GLUD1	activates	gene	0.60
ACO2	expressed_in	gene	0.60
LRPPRC	therapeutic_target	gene	0.60
GLUD1	therapeutic_target	gene	0.60
NDUFS2	therapeutic_target	gene	0.60
GBM	targets	gene	0.60
ACO2	targets	gene	0.60
CYCS	targets	gene	0.60
ACO2	activates	gene	0.60
CYCS	activates	gene	0.60
GBM	associated_with	gene	0.60
ACO2	associated_with	gene	0.60
CYCS	associated_with	gene	0.60
CHCHD2	activates	gene	0.60
CLPP	activates	gene	0.60
FBXO7	activates	gene	0.60
AKT	activates	gene	0.60
PARKINSON'S DISEASE	therapeutic_target	gene	0.60
OXIDATIVE STRESS	therapeutic_target	gene	0.60
GENES	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

HSPA9

Understanding Entity Pages

Summary

Wiki Pages (21)

HSPA9 Gene

Heat Shock Protein Response Pathway in Neurodegeneration

grp75-calcium-homeostasis-parkinsons

Mitochondrial Unfolded Protein Response in Neurodegeneration

NDUFS8 — NADH:Ubiquinone Oxidoreductase Core Subunit S8

DNAJB5 (DnaJ Heat Shock Protein Family Member B5)

Hsp70/Hsp90 Chaperone Pathway in Parkinson's Disease

dnajc4

TIMM21 — Translocase of Inner Mitochondrial Membrane 21

Hsp70 Protein Family

FRDA1 Gene - Frataxin (FXN)

ER-Mitochondria Contact Sites (MAMs) in Neurodegeneration

DNAJC11 Protein

TID1 Gene

HSP70/HSP90 Modulators

HSP70 Protein

TIMM22 Gene - Translocase of Inner Mitochondrial Membrane 22

OMA1 Gene

ACO2 — Aconitase 2