gene

CYCS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CYCS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

361Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

CYCS is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, inhibits. Associated with Als, Alzheimer, Cancer. Connected to 176 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CYCS
Full Name	Cytochrome c
Chromosome	7p15.3
Function	Cytochrome c (CYCS) is a small heme protein located in the mitochondrial intermembrane space that plays a central role in both cellular respiration and apoptosis.
Primary Expression	all aerobic cells, with highest levels in tissues with high metabolic rates including brain, heart, liver, and kidney
Pathways	Oxidative Phosphorylation
UniProt ID	[P99999](https://www.uniprot.org/uniprot/P99999)
Ensembl ID	ENSG00000172115
OMIM	123970
GeneCards	CYCS
Human Protein Atlas	CYCS
Associated Diseases	Als, Alzheimer, Dementia, Diabetes, Inflammation, Ms
Known Drugs/Compounds	rapamycin
Interactions	CDKN1A, BECN1, CAT, ACTB, CTSD, GAPDH
KG Connections	361 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (16)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CYCS["CYCS"]
    CYCS -->|"target for"| Inflammation["Inflammation"]
    CYCS -->|"target for"| Ms["Ms"]
    CYCS -->|"target for"| Parkinson["Parkinson"]
    CYCS -->|"target for"| Diabetes["Diabetes"]
    CYCS -->|"regulates"| Senescence["Senescence"]
    CYCS -->|"target for"| Als["Als"]
    CYCS -->|"target for"| Cancer["Cancer"]
    CYCS -->|"target for"| Tumor["Tumor"]
    CYCS -->|"target for"| RAC1["RAC1"]
    CYCS -->|"target for"| MET["MET"]
    MET -->|"target for"| CYCS
    TPM2["TPM2"] -->|"target for"| CYCS
    RAC1 -->|"target for"| CYCS
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"target for"| CYCS
    VDAC1["VDAC1"] -->|"expressed in"| CYCS
    HSPA9["HSPA9"] -->|"expressed in"| CYCS
    BCL2L1["BCL2L1"] -->|"target for"| CYCS
    MTOR["MTOR"] -->|"target for"| CYCS
    MAPK3["MAPK3"] -->|"target for"| CYCS
    TP53["TP53"] -->|"target for"| CYCS

Outgoing (212)

Target	Relation	Type	Str
Intrinsic Apoptosis	activates	pathway	0.98
Oxidative Phosphorylation	involved_in	process	0.75
CAT	inhibits	gene	0.70
ROS	activates	gene	0.70
Inflammation	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Diabetes	therapeutic_target	disease	0.65
Ms	associated_with	disease	0.65
Senescence	regulates	disease	0.65
Als	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Parkinson	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
Als	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Neuroinflammation	protects_against	disease	0.65
Als	protects_against	disease	0.65
Neurodegeneration	protects_against	disease	0.65
Inflammation	protects_against	disease	0.65
Parkinson	activates	disease	0.65
ALS	protects_against	disease	0.65
ALS	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
GFAP	associated_with	gene	0.60
RAC1	therapeutic_target	gene	0.60
MET	therapeutic_target	gene	0.60
MMP9	associated_with	gene	0.60
VIM	associated_with	gene	0.60
TPM2	therapeutic_target	gene	0.60
NCF1	associated_with	gene	0.60
SOD2	associated_with	gene	0.60
SOD1	associated_with	gene	0.60
P62	associated_with	gene	0.60
UBC	associated_with	gene	0.60
ATG3	associated_with	gene	0.60
ATG7	associated_with	gene	0.60
SCA3	associated_with	gene	0.60
ATG12	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
CDKN1A	inhibits	gene	0.60
P62	regulates	gene	0.60
BECN1	inhibits	gene	0.60
ACTB	inhibits	gene	0.60
SQSTM1	regulates	gene	0.60

Incoming (149)

Source	Relation	Type	Str
SOD2	associated_with	gene	0.60
CDC42	associated_with	gene	0.60
MET	therapeutic_target	gene	0.60
TPM2	therapeutic_target	gene	0.60
GFAP	associated_with	gene	0.60
NCF1	associated_with	gene	0.60
VIM	associated_with	gene	0.60
MMP9	associated_with	gene	0.60
RAC1	therapeutic_target	gene	0.60
VDAC1	expressed_in	gene	0.60
HSPA9	expressed_in	gene	0.60
BCL2L1	therapeutic_target	gene	0.60
MTOR	therapeutic_target	gene	0.60
MAPK3	therapeutic_target	gene	0.60
TP53	therapeutic_target	gene	0.60
SRC	therapeutic_target	gene	0.60
TPM2	associated_with	gene	0.60
RAC1	associated_with	gene	0.60
ATG3	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
SCA3	associated_with	gene	0.60
UBC	associated_with	gene	0.60
ATG7	associated_with	gene	0.60
P62	associated_with	gene	0.60
SOD1	associated_with	gene	0.60
BECN1	inhibits	gene	0.60
ATG5	inhibits	gene	0.60
GAPDH	inhibits	gene	0.60
CAT	inhibits	gene	0.60
ACTB	inhibits	gene	0.60
P62	regulates	gene	0.60
CTSD	inhibits	gene	0.60
CDKN1A	inhibits	gene	0.60
TAU	therapeutic_target	gene	0.60
SNCA	therapeutic_target	gene	0.60
NRXN3	inhibits	gene	0.60
PDHA1	inhibits	gene	0.60
BDNF	inhibits	gene	0.60
PRKAA1	inhibits	gene	0.60
SOD2	protects_against	gene	0.60
SOD1	inhibits	gene	0.60
NLGN2	inhibits	gene	0.60
PSD95	protects_against	gene	0.60
SNCA	expressed_in	gene	0.60
NDUFS1	therapeutic_target	gene	0.60
MET	associated_with	gene	0.60
ACO2	expressed_in	gene	0.60
GLUD1	therapeutic_target	gene	0.60
SLC2A2	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CYCS

Understanding Entity Pages

Summary

Wiki Pages (16)

CYCS

Cytochrome c Protein

UQCRFS1 Gene

PDHA1

Protein Kinase Inhibitors for Neurodegeneration: Investment Landscape Analysis

SCA3 — ATXN3 (Ataxin-3)

TPM2 — Tropomyosin 2

Cytochrome c Protein

ACO2 — Aconitase 2

Nucleus Basalis of Meynert Cholinergic Neurons in Alzheimer's Disease

NRXN3 Gene

HSPA9 Gene

NDUFS1 Gene

NDUFS2 Gene

Proteins

Genes

Pathway Diagram

Outgoing (212)

Incoming (149)

Targeting Hypotheses (0)

Mentioning Analyses (0)

Related Papers (0)