concept

IMMUNE INFILTRATION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IMMUNE INFILTRATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

632Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

IMMUNE INFILTRATION is a concept in neurodegeneration research. Key relationships include: associated with, therapeutic target, expressed in. Associated with Aging, Als, Alzheimer. Connected to 417 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	IMMUNE INFILTRATION
Key Genes/Proteins	INFLAMMATION, CANCER
Related Diseases	Als, Cancer, Inflammation, Tumor, Alzheimer
Related Pathways	Autophagy, Immune Response, Mapk, Mtor

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    IMMUNE_INFILTRATION["IMMUNE INFILTRATION"]
    IMMUNE_INFILTRATION -->|"causes"| INFLAMMATION["INFLAMMATION"]
    IMMUNE_INFILTRATION -->|"activates"| Neuropathy["Neuropathy"]
    IMMUNE_INFILTRATION -->|"activates"| Ms["Ms"]
    IMMUNE_INFILTRATION -->|"target for"| Carcinoma["Carcinoma"]
    IMMUNE_INFILTRATION -->|"target for"| Cancer["Cancer"]
    IMMUNE_INFILTRATION -->|"activates"| Tumor["Tumor"]
    MICROGLIA["MICROGLIA"] -->|"activates"| IMMUNE_INFILTRATION
    ASTROCYTES["ASTROCYTES"] -->|"activates"| IMMUNE_INFILTRATION
    BECN1["BECN1"] -->|"activates"| IMMUNE_INFILTRATION
    PYROPTOSIS["PYROPTOSIS"] -->|"activates"| IMMUNE_INFILTRATION
    GSDME["GSDME"] -->|"activates"| IMMUNE_INFILTRATION
    CD8["CD8"] -->|"activates"| IMMUNE_INFILTRATION
    MMP9["MMP9"] -->|"regulates"| IMMUNE_INFILTRATION
    GADD45A["GADD45A"] -->|"regulates"| IMMUNE_INFILTRATION

Outgoing (355)

Target	Relation	Type	Str
INFLAMMATION	causes	gene	0.90
Als	associated_with	disease	0.85
Cancer	associated_with	disease	0.85
Inflammation	associated_with	disease	0.85
Autophagy	associated_with	pathway	0.80
Cancer	therapeutic_target	disease	0.75
Tumor	associated_with	disease	0.75
Tumor	activates	disease	0.75
Alzheimer	associated_with	disease	0.75
Als	therapeutic_target	disease	0.75
Parkinson	associated_with	disease	0.75
CANCER	associated_with	gene	0.70
Immune Response	therapeutic_target	pathway	0.70
Mapk	biomarker_for	pathway	0.70
Mtor	associated_with	pathway	0.70
Neuropathy	activates	disease	0.65
Ms	activates	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Ms	regulates	disease	0.65
Cancer	activates	disease	0.65
Leukemia	activates	disease	0.65
Ms	biomarker_for	disease	0.65
Ms	associated_with	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Als	expressed_in	disease	0.65
Cancer	inhibits	disease	0.65
Tumor	expressed_in	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Cancer	expressed_in	disease	0.65
Cirrhosis	associated_with	disease	0.65
Hepatitis	associated_with	disease	0.65
Tumor	regulates	disease	0.65
Atherosclerosis	expressed_in	disease	0.65
Diabetes	associated_with	disease	0.65
Fibrosis	associated_with	disease	0.65
Ms	expressed_in	disease	0.65
Ms	interacts_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Senescence	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Autoimmune	therapeutic_target	disease	0.65
Fibrosis	biomarker_for	disease	0.65
Diabetes	biomarker_for	disease	0.65
Als	biomarker_for	disease	0.65
Ischemia	associated_with	disease	0.65
Cardiovascular	biomarker_for	disease	0.65
Atherosclerosis	biomarker_for	disease	0.65
Carcinoma	associated_with	disease	0.65

Incoming (277)

Source	Relation	Type	Str
INFLAMMATION	associated_with	gene	0.80
GENES	associated_with	gene	0.80
ASTROCYTES	activates	gene	0.70
ALZHEIMER'S DISEASE	associated_with	gene	0.70
MMP9	associated_with	gene	0.70
LAMP1	associated_with	gene	0.70
AUTOPHAGY	associated_with	gene	0.70
MICROGLIA	activates	gene	0.60
BECN1	activates	gene	0.60
VPS13C	associated_with	gene	0.60
MITOPHAGY	associated_with	gene	0.60
BNIP3L	associated_with	gene	0.60
PYROPTOSIS	activates	gene	0.60
GSDME	activates	gene	0.60
CD8	activates	gene	0.60
PYCARD	associated_with	gene	0.60
HMOX1	associated_with	gene	0.60
CASP1	associated_with	gene	0.60
NAMPT	associated_with	gene	0.60
TNF	associated_with	gene	0.60
ZFP36	associated_with	gene	0.60
FERROPTOSIS	associated_with	gene	0.60
NOD2	associated_with	gene	0.60
MMP9	regulates	gene	0.60
GADD45A	regulates	gene	0.60
MAPK14	regulates	gene	0.60
HSPD1	inhibits	gene	0.60
CALCOCO2	inhibits	gene	0.60
SCARB2	associated_with	gene	0.60
UBE2D1	associated_with	gene	0.60
LGALS1	associated_with	gene	0.60
CALCOCO2	associated_with	gene	0.60
MIRNAS	interacts_with	gene	0.60
PI3K	regulates	gene	0.60
AKT	regulates	gene	0.60
TFRC	regulates	gene	0.60
FERROPTOSIS	regulates	gene	0.60
PARKINSON'S DISEASE	therapeutic_target	gene	0.60
VDAC1	therapeutic_target	gene	0.60
HSPA9	therapeutic_target	gene	0.60
CYCS	therapeutic_target	gene	0.60
CD4	associated_with	gene	0.60
THBS2	expressed_in	gene	0.60
CTSK	expressed_in	gene	0.60
MARCKS	expressed_in	gene	0.60
PYROPTOSIS	associated_with	gene	0.60
MIRNAS	associated_with	gene	0.60
OPA1	associated_with	gene	0.60
CD8	associated_with	gene	0.60
MITOCHONDRIAL DYSFUNCTION	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

IMMUNE INFILTRATION

Understanding Entity Pages

Summary

Wiki Pages (20)

Atypical Parkinsonism

neuroinflammation

Blood-Brain Barrier Dysfunction in Neurodegeneration

Rapamycin ALS Trial - mTOR Inhibition for Amyotrophic Lateral Sclerosis

Traumatic Brain Injury and Neurodegeneration Pathway

Psychobiotic Therapy for Neurodegenerative Diseases

Neuroinflammation in Parkinson's Disease

Neuroinflammation Microglia

Adaptive Immunity in Neurodegeneration

Deep-Cerebellar-Nuclei-in-Ataxia

potassium-channel-openers-parkinsons

Senolytic Therapies for CBS and [PSP](/diseases/progressive-supranuclear-palsy)

Neuroinflammation in Alzheimer's Disease

CSF1R Inhibitors for Parkinson's Disease

mTOR Signaling in Neurodegeneration

Interferon Signaling in Neurodegeneration