concept

IMMUNE INFILTRATION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IMMUNE INFILTRATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

624Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

IMMUNE INFILTRATION is a concept in neurodegeneration research. Key relationships include: associated with, therapeutic target, expressed in. Associated with Aging, Als, Alzheimer. Connected to 417 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	IMMUNE INFILTRATION
Key Genes/Proteins	ACO2, AGING, AIM2, AKT, AKT1, ALZHEIMER
Related Diseases	aging, Aging, Als, ALS, Alzheimer
Related Pathways	Adaptive Immunity, Akt

Pathway Diagram

graph TD
    IMMUNE_INFILTRATION["IMMUNE INFILTRATION"]
    IMMUNE_INFILTRATION -->|"causes"| INFLAMMATION["INFLAMMATION"]
    IMMUNE_INFILTRATION -->|"activates"| Neuropathy["Neuropathy"]
    IMMUNE_INFILTRATION -->|"activates"| Ms["Ms"]
    IMMUNE_INFILTRATION -->|"target for"| Carcinoma["Carcinoma"]
    IMMUNE_INFILTRATION -->|"target for"| Cancer["Cancer"]
    IMMUNE_INFILTRATION -->|"activates"| Tumor["Tumor"]
    MICROGLIA["MICROGLIA"] -->|"activates"| IMMUNE_INFILTRATION
    ASTROCYTES["ASTROCYTES"] -->|"activates"| IMMUNE_INFILTRATION
    BECN1["BECN1"] -->|"activates"| IMMUNE_INFILTRATION
    PYROPTOSIS["PYROPTOSIS"] -->|"activates"| IMMUNE_INFILTRATION
    GSDME["GSDME"] -->|"activates"| IMMUNE_INFILTRATION
    CD8["CD8"] -->|"activates"| IMMUNE_INFILTRATION
    MMP9["MMP9"] -->|"regulates"| IMMUNE_INFILTRATION
    GADD45A["GADD45A"] -->|"regulates"| IMMUNE_INFILTRATION

Outgoing (350)

Target	Relation	Type	Str
Septic Cardiomyopathy	contributes_to	disease	0.95
INFLAMMATION	causes	gene	0.90
Als	associated_with	disease	0.85
Cancer	associated_with	disease	0.85
Inflammation	associated_with	disease	0.85
Autophagy	associated_with	pathway	0.80
Parkinson	associated_with	disease	0.75
Als	therapeutic_target	disease	0.75
Cancer	therapeutic_target	disease	0.75
Tumor	activates	disease	0.75
Tumor	associated_with	disease	0.75
Alzheimer	associated_with	disease	0.75
Immune Response	therapeutic_target	pathway	0.70
Mapk	biomarker_for	pathway	0.70
Mtor	associated_with	pathway	0.70
CANCER	associated_with	gene	0.70
Leukemia	activates	disease	0.65
Cancer	activates	disease	0.65
Tumor	regulates	disease	0.65
Ms	regulates	disease	0.65
Neuropathy	activates	disease	0.65
Ms	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Aging	biomarker_for	disease	0.65
Ulcerative Colitis	interacts_with	disease	0.65
Dementia	associated_with	disease	0.65
Inflammation	activates	disease	0.65
Inflammation	interacts_with	disease	0.65
Als	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Aging	associated_with	disease	0.65
Sepsis	biomarker_for	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Diabetes	associated_with	disease	0.65
Glioma	activates	disease	0.65
Hepatitis	associated_with	disease	0.65
Cirrhosis	associated_with	disease	0.65
Ms	expressed_in	disease	0.65
Infection	activates	disease	0.65
Fibrosis	associated_with	disease	0.65
Glioblastoma	therapeutic_target	disease	0.65
Tumor	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Cardiovascular	biomarker_for	disease	0.65
Carcinoma	associated_with	disease	0.65
Atherosclerosis	biomarker_for	disease	0.65
Migraine	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Cancer	inhibits	disease	0.65

Incoming (274)

Source	Relation	Type	Str
GENES	associated_with	gene	0.80
INFLAMMATION	associated_with	gene	0.80
MMP9	associated_with	gene	0.70
ASTROCYTES	activates	gene	0.70
ALZHEIMER'S DISEASE	associated_with	gene	0.70
AUTOPHAGY	associated_with	gene	0.70
LAMP1	associated_with	gene	0.70
ZFP36	associated_with	gene	0.60
FERROPTOSIS	associated_with	gene	0.60
CASP1	associated_with	gene	0.60
PI3K	regulates	gene	0.60
TNF	associated_with	gene	0.60
AKT	regulates	gene	0.60
TFRC	regulates	gene	0.60
FERROPTOSIS	regulates	gene	0.60
PARKINSON'S DISEASE	therapeutic_target	gene	0.60
VDAC1	therapeutic_target	gene	0.60
PLIN1	expressed_in	gene	0.60
MIRNAS	interacts_with	gene	0.60
PIK3CA	associated_with	gene	0.60
IGF1	expressed_in	gene	0.60
P2RY14	expressed_in	gene	0.60
MMP9	interacts_with	gene	0.60
FOS	interacts_with	gene	0.60
EGFR	associated_with	gene	0.60
OPA1	associated_with	gene	0.60
CD8	associated_with	gene	0.60
MITOCHONDRIAL DYSFUNCTION	associated_with	gene	0.60
CD44	biomarker_for	gene	0.60
IGF1	biomarker_for	gene	0.60
EGF	biomarker_for	gene	0.60
CD4	regulates	gene	0.60
REL	regulates	gene	0.60
CYCS	therapeutic_target	gene	0.60
STAT3	regulates	gene	0.60
CD8	regulates	gene	0.60
CDK6	associated_with	gene	0.60
RAB7A	associated_with	gene	0.60
TGFBR1	associated_with	gene	0.60
VEGF	associated_with	gene	0.60
JUNB	associated_with	gene	0.60
TFRC	associated_with	gene	0.60
DIABETES MELLITUS	associated_with	gene	0.60
ENO1	associated_with	gene	0.60
NPM1	associated_with	gene	0.60
HK2	associated_with	gene	0.60
P53	associated_with	gene	0.60
HSPA9	therapeutic_target	gene	0.60
IL1B	associated_with	gene	0.60
SOD2	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IMMUNE INFILTRATION in their description or question text

No additional research found