Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about AP-1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | AP-1 |
| Key Genes/Proteins | JUN, LXR, BATF3 |
| Related Diseases | cell proliferation, cell differentiation, apoptosis, Senescence-Associated Stem Cell-Like Features |
| Related Pathways | Kupffer Cell Enhancers, Kupffer cell enhancers |
Knowledge base pages for this entity
graph TD
AP_1["AP-1"]
AP_1 -->|"regulates"| cell_proliferation["cell proliferation"]
AP_1 -->|"regulates"| cell_differentiation["cell differentiation"]
AP_1 -->|"regulates"| apoptosis["apoptosis"]
AP_1 -->|"regulates"| JUN["JUN"]
AP_1 -->|"upregulates"| MMP1["MMP1"]
AP_1 -->|"regulates"| Kupffer_Cell_Enhancers["Kupffer Cell Enhancers"]
AP_1 -->|"regulates"| Senescence["Senescence"]
AP_1 -->|"modulates"| LXR["LXR"]
Quercetin["Quercetin"] -->|"downregulates"| AP_1
JUN -->|"component_of"| AP_1
Pvr["Pvr"] -->|"activates"| AP_1
BATF3["BATF3"] -->|"interacts"| AP_1
p_Hydroxybenzaldehyde["p-Hydroxybenzaldehyde"] -->|"inhibits"| AP_1| Target | Relation | Type | Str |
|---|---|---|---|
| cell proliferation | regulates | phenotype | 0.90 |
| cell differentiation | regulates | phenotype | 0.90 |
| apoptosis | regulates | phenotype | 0.90 |
| JUN | regulates | gene | 0.90 |
| Kupffer Cell Enhancers | regulates | mechanism | 0.90 |
| Senescence | regulates | process | 0.90 |
| LXR | modulates | protein | 0.85 |
| Senescence-Associated Stem Cell-Like Features | regulates | phenotype | 0.85 |
| HUVECs Apoptosis | mediates | process | 0.85 |
| Kupffer cell enhancers | regulates | pathway | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Quercetin | downregulates | compound | 0.92 |
| JUN | component_of | gene | 0.90 |
| BATF3 | interacts_with | gene | 0.80 |
| p-Hydroxybenzaldehyde | inhibits | compound | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||