concept

AP-1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AP-1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

15Connections
0Hypotheses
0Analyses
10Outgoing
4Incoming

No summary available yet. View on Wiki →

💡 Concept Info
NameAP-1
Key Genes/ProteinsJUN, LXR, BATF3
Related Diseasescell proliferation, cell differentiation, apoptosis, Senescence-Associated Stem Cell-Like Features
Related PathwaysKupffer Cell Enhancers, Kupffer cell enhancers

Wiki Pages (20)

Knowledge base pages for this entity

NPM1 Gene

gene · 5653 words

neuroinflammation

mechanism · 5462 words

Neuroinflammation-Mitochondria Crosstalk Pathway

mechanism · 3966 words

TYNDASE — Tyndall

gene · 3964 words

RASGRP1 Gene

gene · 3531 words

Pathway Diagram

graph TD
    AP_1["AP-1"]
    AP_1 -->|"regulates"| cell_proliferation["cell proliferation"]
    AP_1 -->|"regulates"| cell_differentiation["cell differentiation"]
    AP_1 -->|"regulates"| apoptosis["apoptosis"]
    AP_1 -->|"regulates"| JUN["JUN"]
    AP_1 -->|"upregulates"| MMP1["MMP1"]
    AP_1 -->|"regulates"| Kupffer_Cell_Enhancers["Kupffer Cell Enhancers"]
    AP_1 -->|"regulates"| Senescence["Senescence"]
    AP_1 -->|"modulates"| LXR["LXR"]
    Quercetin["Quercetin"] -->|"downregulates"| AP_1
    JUN -->|"component_of"| AP_1
    Pvr["Pvr"] -->|"activates"| AP_1
    BATF3["BATF3"] -->|"interacts"| AP_1
    p_Hydroxybenzaldehyde["p-Hydroxybenzaldehyde"] -->|"inhibits"| AP_1

Outgoing (11)

TargetRelationTypeStr
cell proliferationregulatesphenotype0.90
cell differentiationregulatesphenotype0.90
apoptosisregulatesphenotype0.90
JUNregulatesgene0.90
Kupffer Cell Enhancersregulatesmechanism0.90

Incoming (4)

SourceRelationTypeStr
Quercetindownregulatescompound0.92
JUNcomponent_ofgene0.90
BATF3interacts_withgene0.80
p-Hydroxybenzaldehydeinhibitscompound0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found