process

apoptosis

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about apoptosis: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

12606Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

Summary

apoptosis is a biological process related to neurodegeneration research. Key relationships include: activates, regulates, inhibits. Associated with ALS, Alzheimer's disease, cancer. Connected to 115 entities in the SciDEX knowledge graph.

View on Wiki →

🧬 Biological Process Info

Name	apoptosis
Summary	# [Apoptosis](/entities/apoptosis)[/entities/apoptosis](/entities/apoptosis)[1] ## Introduction [Apoptosis](/entities/apoptosis)[/entities/apoptosis(entities/apoptosis) is an important component in
Key Genes/Proteins	caspase family, P53, BAX, FBL, ASPP1, AP-1
Related Diseases	Alzheimer's disease, oncogenesis, tissue homeostasis, prostate cancer
Related Pathways	PI3K/AKT/GSK3β

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    apoptosis["apoptosis"] -->|"causes"| Alzheimer_s_disease["Alzheimer's disease"]
    apoptosis["apoptosis"] -->|"causes"| neuronal_cell_death["neuronal cell death"]
    apoptosis["apoptosis"] -->|"associated"| neurodegeneration["neurodegeneration"]
    apoptosis["apoptosis"] -->|"associated"| cancer["cancer"]
    apoptosis["apoptosis"] -->|"regulates"| tissue_homeostasis["tissue homeostasis"]
    apoptosis["apoptosis"] -->|"regulates"| BCL2["BCL2"]
    AP_1["AP-1"] -->|"regulates"| apoptosis["apoptosis"]
    R_PE["R-PE"] -->|"activates"| apoptosis["apoptosis"]
    caspases["caspases"] -->|"activates"| apoptosis["apoptosis"]
    TNF__["TNF-alpha"] -->|"activates"| apoptosis["apoptosis"]
    style apoptosis fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (5242)

Target	Relation	Type	Str
Alzheimer's disease	causes	disease	0.90
oncogenesis	prevents	phenotype	0.90
tissue homeostasis	promotes	phenotype	0.90
prostate cancer	prevents	disease	0.90
cellular homeostasis	maintains	process	0.88
neuronal cell death	causes	phenotype	0.80
lithium chloride-induced brain damage	mediates	process	0.80
spermatocytes	associated_with	cell_type	0.80
Depression	implicated_in	disease	0.80
major depressive disorder	associated_with	disease	0.75
neurodegeneration	associated_with	disease	0.70
cancer	associated_with	disease	0.70
tissue homeostasis	regulates	process	0.70
BCL2	regulates	protein	0.70
nervous system	regulates	brain_region	0.70
Alzheimer's disease	associated_with	disease	0.70
cellular homeostasis	activates	process	0.70
brain homeostasis	regulates	process	0.70
neurodegeneration	activates	process	0.70
postoperative cognitive dysfunction	causes	disease	0.70
cellular homeostasis	regulates	process	0.70
ALS	associated_with	disease	0.70
pericyte	co_discussed	concept	0.65
granulosa_cells	regulates	cell_type	0.64
neurodegeneration	causes	entity	0.60
HSPA1A	activates	gene	0.60
autophagy	binds_to	pathway	0.60
EIF2AK3	inhibits	gene	0.60
TAAR1	activates	gene	0.60
PLA2G6	binds_to	gene	0.60
neuroinflammation	binds_to	process	0.60
oxidative stress	binds_to	process	0.60
STAT3	binds_to	gene	0.60
NR3C1	inhibits	gene	0.60
C1QA	inhibits	gene	0.60
necroptosis	binds_to	pathway	0.60
pyroptosis	binds_to	pathway	0.60
NLRP3	binds_to	gene	0.60
ERN1	inhibits	gene	0.60
TRAF6	activates	gene	0.60
MAF	inhibits	gene	0.60
CHMP4B	binds_to	gene	0.60
MLCK	inhibits	gene	0.60
NTN1	activates	gene	0.55
TFEB	activates	gene	0.55
PANX1	activates	gene	0.55
SPTLC1	regulates	gene	0.55
oxidative stress	inhibits	phenotype	0.50
Reactive Oxygen Species	activates	process	0.50
DEMENTIA	activates	gene	0.50

Incoming (7364)

Source	Relation	Type	Str
caspase family	activates	protein	0.95
P53	activates	gene	0.95
BCL2 inhibitors	promotes	drug	0.95
BAX	promotes	gene	0.95
BCL-2	regulates	protein	0.95
FBL	mediates	protein	0.95
hepatocytes	involved_in	cell_type	0.95
ASPP1	promotes	protein	0.93
BCL-2 inhibitors	promotes	drug	0.93
P53	regulates	protein	0.92
PI3K/AKT/GSK3β	inhibits	pathway	0.91
AP-1	regulates	protein	0.90
R-PE	activates	drug	0.90
caspases	activates	protein	0.90
TNF-α	activates	protein	0.90
amyloid-beta	causes	protein	0.90
tau	causes	protein	0.90
BCL2	inhibits	gene	0.90
BAX	activates	gene	0.90
BAD	activates	gene	0.90
caspase-3	activates	protein	0.90
gallic acid	inhibits	drug	0.90
R-phycoerythrin	activates	drug	0.90
BCL2 family	regulates	gene	0.90
FAS	activates	protein	0.90
TNF-alpha	activates	protein	0.90
TP53	activates	gene	0.90
caspases	causes	protein	0.90
BCL2	regulates	gene	0.90
TNF	causes	protein	0.90
R-PE	causes	drug	0.90
mitophagy	inhibits	pathway	0.90
EGFR	regulates	gene	0.90
TP53	regulates	gene	0.90
NLRP3	causes	protein	0.90
PI3K/Akt/mTOR	regulates	pathway	0.90
AKT	inhibits	protein	0.90
PI3K/Akt/MTOR	regulates	pathway	0.90
STAU1	promotes	protein	0.90
PUMA	activates	protein	0.90
B.glomerulata	inhibits	drug	0.90
BCL-2	inhibits	protein	0.90
nucleolar stress	associated_with	process	0.90
CASP8	mediates	gene	0.90
PI3K/Akt signaling pathway	regulates	pathway	0.90
SIRT1	modulates	protein	0.88
T3 (triiodothyronine)	prevents	drug	0.88
IGF1R	inhibits	protein	0.87
PET-MPs	modulates	drug	0.87
MTOR	inhibits	protein	0.85

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

How does controlled lysosomal membrane permeabilization induce autophagy without

neurodegeneration | 2026-04-07 | 0 hypotheses

Lysosomal dysfunction and cathepsin leakage in Alzheimer disease progression

neuroscience | 2026-04-04 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

apoptosis

Understanding Entity Pages

Summary

Wiki Pages (21)

Apoptosis in Neurodegeneration

cbs-psp-daily-action-plan

Corticobasal Syndrome (CBS)

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Parthanatos in Neurodegeneration

calcium-dysregulation-comparison

Alzheimer's Disease Mechanism Index

Corticobasal Degeneration (CBD)

nimodipine-als

NPM1 Gene

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

Neurons — Cell Type Hierarchy

neuroinflammation

CBS/PSP Treatment Rankings

coq10-neurodegeneration

NTF4 Protein

Mitochondrial Quality Control

Astrocyte Reactivity Mechanism

GSK-3β in Neurodegeneration

Growth Factor Therapies

Mitochondrial Dysfunction in Parkinson's Disease